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Instructions

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Instruction for use: Hemofer prolongatum

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Dosage form: dragee

Active substance: Ferri sulfas

ATX

B03AA07 Iron sulphate

Pharmacological groups

Macro and trace elements

Stimulators of hemopoiesis

The nosological classification (ICD-10)

D50.9 Iron deficiency anemia, unspecified: Iron deficiency anemia; Lack of iron in food; Insufficient absorption of iron from the gastrointestinal tract; Insufficient food intake of iron; Hypochromic iron deficiency anemia; Hypochromic anemia; Iron deficiency anemia in pregnant women; Iron deficiency; Disturbance of absorption of iron from the digestive tract; Combined iron-folic-B12-deficient anemia; Anemia due to violations of hemoglobin synthesis and iron metabolism; Anemia in disorders of iron utilization and reutilization; Impaired iron absorption; Impaired absorption of iron; Insufficient absorption of iron in the digestive tract

Composition

Dragee - 1 dragee (325 mg)

Iron sulphate

Auxiliary substances: lactose monohydrate; Ammonium methacrylate copolymer; talc; Magnesium stearate

Tablet shell: sucrose; talc; Arabic gum; gelatin; Dye red E124; Capol 1295

In the blister 10 pcs .; In a box of cardboard 3 blisters.

Pharmachologic effect

Mode of action - Replenishing iron deficiency, anti-anemia.

Participates in the construction of hemoglobin, myoglobin, as well as enzymes (including cytochromes, catalases, peroxidases), stimulates erythropoiesis, regulates the processes of tissue respiration.

Pharmacodynamics

Part of the iron that enters the body is used for the synthesis of iron-containing compounds, the other is deposited in the form of ferritin and hemosiderin, mainly in the liver and spleen.

The daily need for iron of a healthy adult is 3-4 mg / day.

Pharmacokinetics

The degree of iron absorption depends on the iron deficiency in the body. In people with a significant iron deficiency, the absorption rate is 10-30% (while for people with normal levels of iron - 5-15%). Preparations of Fe2 + do not require a preliminary reduction and are easily absorbed in the duodenum and in the upper part of the small intestine. After binding to the protein transferrin transferrin, iron enters the systemic bloodstream and is used to construct iron-containing compounds or to form a reserve iron pool.

Indication of the drug Hemofer prolongatum

Hypochromic iron deficiency anemia, with insufficient intake of iron in the body or increased need for iron: pregnancy, breast-feeding, donation, a period of active growth, blood loss (surgery, childbirth, excessive menstrual or irregular and profuse bleeding in menopause).

Contraindications

Gastrointestinal dysfunction that interferes with iron absorption, iron metabolism disorders, hemosiderosis, hemochromatosis, anemia not caused by iron deficiency (hemolytic or aplastic).

Side effects

From the nervous system and sensory organs: dizziness, headache.

From the side of the cardiovascular system and blood (hematopoiesis, hemostasis):

A feeling of pressure behind the sternum.

On the part of the intestine: pain in the abdomen, nausea, diarrhea or constipation.

Other: hyperemia of the face, mild weakness, malaise.

Interaction

Tetracyclines, fluoroquinolones, D-penicillamine and gastric acid-lowering agents reduce iron absorption, vitamin C-increases.

Dosing and Administration

Inside, between meals or on an empty stomach. Adults and children over 12 years of age, with the goal of prevention - 1 dragee once a day; For treatment - 1 tablet twice a day with an interval of 12 hours. Duration of treatment - from 2 weeks to 6 months. If symptoms of intolerance arise from the GI tract, the drug should be taken immediately after a meal.

Overdose

Symptoms: nausea, vomiting, abdominal pain, diarrhea, increased capillary permeability, rapid pulse, cardiovascular collapse.

Treatment: gastric lavage, administration of deferoxamine (binds iron ions).

Precaution Measures

It should be borne in mind that the use for a long time, significantly exceeding the necessary for replenishing the resources of iron, can cause metabolic acidosis, convulsions, coma, necrosis of the liver and death. During treatment, every 3-4 weeks should monitor the morphological composition of blood and the concentration of iron in the blood.

With caution apply for peptic ulcer of the stomach, duodenal ulcer, ulcerative colitis, enteritis.

Special instruction

Stains the feces black.

Storage conditions of the drug Hemofer prolongatum

In a dry place, at a temperature of no higher than 25 C.

Keep out of the reach of children.

Shelf life of the drug Hemofer prolongatum

3 years.

Do not use after the expiry date printed on the package.

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