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Instructions

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Instruction for use: Gutron

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Active substance: Midodrine * (Midodrine)

code C01CA17 Midodrine

Pharmacotherapeutic group:

Alpha-adrenoceptor agonists

The nosological classification (ICD-10)

I95 Hypotension

Hypotension,Age hypotension, arterial Hypertension, Hypotonic disease, hypotonic reaction, postural hypotension, Symptomatic hypotension, Essential hypotension

I95.1 Orthostatic hypotension

Idiopathic orthostatic hypotension, Orthostatic hypotension, orthostatic syndrome, Reactions by type asimpatikotonii

R32 Urinary incontinence unspecified

daytime enuresis, Idiopathic bladder instability, Urinary incontinence

nocturia, The disorder of the bladder sphincter function, Spontaneous urination, Mixed forms of urinary incontinence, Functional disorders of micturition, Functional micturition disorders, Functional enuresis in children, Enuresis

Characteristic

Tablets 1 tab.

midodrine hydrochloride 2.5 mg/ 5 mg

in blister 10 pcs .; in a cardboard box two blisters.

Drops for oral administration of 1 ml of 1%

midodrine hydrochloride 10 mg

(120 mg ethyl alcohol)

1 ml = 30 drops

in dark glass bottles of 10, 20 or 25 ml; in box 1 bottle.

Pharmacological Properties of GutronPharmachologic effect
vasoconstrictor, hypertensive.

Selectively stimulates peripheral alpha-adrenergic receptors.

pharmacodynamics

Increases tone and peripheral resistance of blood vessels, increases blood pressure and prevents (if orthostatic violations) stagnation of blood in the venous line. This leads to the preservation of a constant level of circulating blood volume and blood pressure, increase in the delivery of blood to the organs of elimination and orthostatic disorders. It does not directly affect the activity of the heart, the central nervous system (does not cause sleep disturbance). It improves the function of the sphincter of the bladder.

Pharmacokinetics

When oral administration is rapidly absorbed, becoming active metabolite. After the on / in the injection action develops relatively slowly and persists for a long time. T1 / 2 of the active metabolite in plasma is 4.3 hours. Due to the very low lipophilicity hardly penetrates through the BBB. Midodrine and its metabolites are excreted in the urine almost completely within 24 hours

Indications for Gutron
Hypotension (caused by intake of psychotropic drugs, symptomatic during convalescence after surgery, childbirth, etc.), Orthostatic hypotension (in violation of the regulation of blood circulation and circulatory dysregulation, with responses by type and sympathicotonia asimpatikotonii, idiopathic, secondary); hypotonic reaction (when the weather changes, the morning, when the predisposition to low blood pressure); spontaneous urination (when the sphincter function disorders of the bladder).

Contraindications for Gutron

Hypertension, angle-closure glaucoma, pheochromocytoma, hyperthyroidism, acute nephritis, severe kidney failure, mechanical obstruction of the urinary tract, prostate adenoma with residual urine.

Pregnancy and breast-feeding

Acceptable, but only after consulting a specialist.

Side effect of Gutron

Irregular heartbeat, the appearance of pain in the heart, allergic reactions (rash).

Dosage and Administration

Tablets: adults, children, adolescents (12 years and older) - inside, 2.5 mg 2 times a day (morning and evening), if necessary - 3 times a day, in some cases, the dosage may be reduced to 2 times 1/2 Table. per day (2.5 mg); while the appointment with sedatives or hypnotics first taking 2.5 mg 2 times a day, and then (if necessary) to increase the dose of 5 mg 2-3 times daily; Children up to 12 years - the dose is calculated according to body weight.

Drops: Adults and children over 12 years - inside 7 drops 2 times a day (morning and evening), if necessary, reduce the dose to 3 drops 2 times a day or in rare cases increased to 7 drops 3 times a day; in combination with psychotropic drugs - 7 2 drops twice a day, or (if necessary) in 15 drops 2-3 times daily; Children under 12 years are dosed according to body weight.

Drops should be taken with a small amount of water or on a piece of sugar.

Overdose of Gutron
Symptoms "goose" the skin, especially in the area of the head (occiput) and the neck, feeling cold, urinary retention, urination (as a consequence), possible (reflex), heart rate deceleration (at rest below 60 beats per minute).

Treatment: the use of atropine in normal doses.

Precautionary measures

In severe organic lesions of the cardiovascular system, heart rhythm disturbances and kidney function requires a mandatory correction of dosing. Particular attention to the dosage of pay in the case of the treatment of hypotension caused by weather changes, by pointing at a hypertension history. With prolonged use or after an intensive course necessary to examine kidney function.

Storage conditions of Gutron

In the dark place at a temperature no higher than 25 C.

Keep out of the reach of children.
Shelf life of Gutron

solution-drops of 1% - 3 years.

2.5 mg Tablets - 2 years.

5 mg tablets - 2 years.

Do not use beyond the expiration date printed on the package.

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