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Instruction for use: Florinef

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Active substance Fludrocortisone

ATX code H02AA02 Fludrocortisone

Pharmacological group



Nosological classification (ICD-10)

E25 Adrenogenital disorders

Macroghenytozomy in boys, Adrenogenital syndrome, Decreased function of the sex glands, Congenital dysfunction of the adrenal cortex, Apera-Halle Syndrome, Crook-Apera-Halle Syndrome

E27.4 Other and unspecified adrenocortical insufficiency

Hypocorticism, Hypoaldosteronism, Adrenal insufficiency, Insufficiency of the adrenal cortex, Insufficiency of the adrenal cortex, Secondary adrenocortical insufficiency, Secondary adrenal insufficiency, Secondary insufficiency of the adrenal cortex, Temporary decrease in the function of the adrenal cortex, Dysfunction of the adrenal cortex

Composition and form of release

1 tablet contains fludrocortisone acetate 0.1 mg; In bottles of 100 pcs.

pharmachologic effect

Pharmacological action - glucocorticoid.

Replenishes the deficiency of hormones of the adrenal cortex. Participates in the metabolism, incl. Mineral and carbohydrate; Causes sodium ion retention and promotes the excretion of potassium.


Substitution therapy with severe adrenocortical insufficiency, in particular, with Addison's disease, adrenogenital syndrome with loss of salts.


Mental diseases in history, herpetic viral infections, amebiasis, systemic mycoses, peptic ulcer and duodenal ulcer, poliomyelitis, osteoporosis, the period before and after immunization.

pregnancy and breastfeeding

During pregnancy (especially in the first trimester) is prescribed only for absolute indications. Lactating women should stop breastfeeding.

Side effects

At use of high doses - oppression of pituitary function (pituitary secretion of ACTH), decrease in thymus activity and cortisol formation, gluconeogenesis activation, negative nitrogen balance, growth inhibition in children, subcapsular cataracts, increased intraocular pressure, petechiae, erosive and ulcerative gastrointestinal disorders, menstrual disturbances Cycle, edema, increased blood pressure, aseptic necrosis of bones.

Dosing and Administration

Inside, from 0.1 mg 3 times a week - up to 0.2 mg per day. Patients with arterial hypertension - 0.05 mg per day. It is recommended to appoint in combination with cortisone (6.25-25 mg per day) or hydrocortisone (5-20 mg per day), especially with substitution therapy.

Precautionary measures

With caution appoint for ulcer disease in history, myasthenia gravis, diverticulitis, recently performed anastomosis of the intestine, propensity to thrombosis and embolism, metastatic carcinoma, tuberculosis (activation of the process is possible), diabetes mellitus (likely decompensation). To avoid edema and increase blood pressure, patients are advised to follow a diet with restriction of consumption of table salt. If there are infections on the background of drug treatment, immediate administration of antibiotics or chemotherapy is necessary. With prolonged treatment should regularly monitor the concentration of electrolytes and glucose in the blood serum.

storage conditions

Keep out of the reach of children.

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