Instruction for use: Ferrous fumarate + Folic acid

Trade name of the drug – Ferretab® comp.

The Latin name of the substance Ferrous fumarate + Folic acid

Ferri fumaras+Acidum folicum (genus. Ferri fumaratis+Acidi folici)

Pharmacological groups:

Stimulants of hemopoiesis in combinations

Macro and trace elements in combinations

Model clinical-pharmacological article 1

Pharmacotherapy. Fe2 + fumarate maintains and restores the normal concentration of Fe in the blood. The amount of assimilable Fe depends on the degree of its deficiency and is 5-35%. In the serum, Fe binds to transferrin and is involved in the formation of Hb, myoglobin, cytochrome oxidase, catalase and peroxidase, or is stored in RES organs. Folic acid in the body is restored to tetrahydrofolic acid, which is a coenzyme involved in various metabolic processes. Stimulates erythropoiesis, participates in the synthesis of amino acids, nucleic acids, purines, pyrimidines, in the exchange of choline.

Pharmacokinetics. After ingestion, Fe and folic acid are absorbed mainly in the upper gastrointestinal tract. Relationship of folic acid with plasma proteins - 64%. Metabolism is in the liver. The Fe is excreted with fecal masses, kidneys and with sweat; Folic acid - kidney, partially through the intestine.

Indication. Iron deficiency anemia with folic acid deficiency associated with pregnancy, impaired absorption of Fe from the gastrointestinal tract, prolonged bleeding, malnutrition (treatment and prevention), prevention of anemia, miscarriage, early birth.

Contraindications. Hypersensitivity, aplastic anemia, hemolytic anemia, hemosiderosis, hemochromatosis, impaired iron absorption, anemia, not related to deficiency of Fe (including hemolytic anemia, lead anemia, megaloblastic anemia).

Dosing. Inside, 50 mg (in terms of Fe2 +, 1 capsule contains 50 mg of Fe2 +) per day on an empty stomach, plenty of it with a liquid; If necessary, increase the dose to 100-150 mg (2-3 capsules) per day. Supportive treatment - 4 weeks after reaching the normal concentration of Fe and Hb in the blood serum.

Side effect. Allergic reactions, nausea, vomiting, constipation, gastralgia, staining of feces in dark color (of clinical significance does not matter).

Interaction. Reduces the absorption of tetracycline antibiotics.

Penicillamine and non-system antacids reduce absorption (the interval between taking these drugs should be at least 3 hours).

Antacids, colestyramine, phenytoin, phenobarbital, carbamazepine, sulfasalazine, hormonal contraceptives, folic acid antagonists, trimethoprim, triamterene, solid food, bread, raw cereals, dairy products, eggs, tea reduce Fe absorption.

With the simultaneous appointment of GCS, it is possible to enhance the stimulation of erythropoiesis.

Special instructions. Therapy should be carried out before the blood picture is normalized. The benzidine test gives a false positive result.