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DR. DOPING

Instructions

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Instruction for use: Darob

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Active substance: Sotalol

ATX Code C07AA07 Sotalol

Pharmacotherapeutic group:

Beta-blockers

The nosological classification (ICD-10)

I47.1 Supraventricular tachycardia

Supraventricular paroxysmal tachycardia; supraventricular tachyarrhythmia; supraventricular tachycardia; Supraventricular arrhythmias; Supraventricular paroxysmal tachycardia; supraventricular tachyarrhythmias; supraventricular tachycardia; Neurogenic sinus tachycardia; orthodromic tachycardia; Paroxysmal supraventricular tachycardia; Paroxysm of supraventricular tachycardia; Paroxysm of supraventricular tachycardia with WPW-syndrome; Paroxysm of atrial tachycardia; Paroxysmal supraventricular tachyarrhythmia; Paroxysmal supraventricular tachycardia; Politopnye atrial tachycardia; Atrial fibrillation; Atrial tachycardia is true; Atrial tachycardia; Atrial tachycardia with AV block; reperfusion arrhythmias; Reflex Bertsolda-Jarisch; Recurrent sustained supraventricular paroxysmal tachycardia; Symptomatic ventricular tachycardia; Sinus tachycardia; Supraventricular paroxysmal tachycardia; supraventricular tachyarrhythmia; supraventricular tachycardia; supraventricular arrhythmia; supraventricular arrhythmias; Tachycardia of AV connections; supraventricular tachycardia; Tachycardia orthodromic; sinus tachycardia; The nodal tachycardia; Chaotic atrial tachycardia politopnye; Wolff-Parkinson-White

I47.2 Ventricular tachycardia

Torsades de pointes (torsade de pointes), Symptomatic ventricular tachycardia, Torsades de pointes in myocardial infarction, Ventricular fibrillation, Ventricular tachycardia , Ventricular tachyarrhythmias, Life-threatening ventricular arrhythmias, Sustained ventricular tachycardia, Sustained monomorphic ventricular tachycardia, Paroxysmal ventricular tachycardia torsades, Paroxysmal ventricular tachycardia

I49.9 Irregular heartbeat, unspecified

Paroxysmal supraventricular tachycardia; extrasystole arrhythmia; Atrial fibrillation tachysystolic; supraventricular tachyarrhythmia; supraventricular arrhythmias; AV reciprocating tachycardia; AV-nodal reciprocating tachycardia; ventricular fibrillation; Irregular heartbeat; Antidromic reciprocating tachycardia; Cardiac arrhythmias; Arrhythmias; Arrhythmia; Heart arythmy; Arrhythmia due to hypokalemia; ventricular tachyarrhythmias; The high frequency of ventricular contraction; Cardiac arrhythmias; Paroxysmal supraventricular arrhythmia; Paroxysmal supraventricular arrhythmia; Paroxysmal dysrhythmia; Paroxysmal atrial-ventricular rhythm; cardiac arrhythmias; supraventricular tachycardia; tachyarrhythmia; Precordial abnormal pulsation

Composition

1 tablet contains sotalol hydrochloride and 160 mg of 80; in blister 10 pcs., in box 2 of the blister.

1 vial of 4 ml of solution for injection - 40 mg.

Pharmacological Properties
Pharmachologic effect

antiarrhythmic.

Beta-adrenoceptor blocking.

Indications

Supraventricular tachyarrhythmias (tachycardia of the AV connection, supraventricular tachycardia with WPW-syndrome, paroxysm of atrial fibrillation), ventricular tachycardia.

Contraindications

Hypersensitivity (including to sulfonamides), congestive heart failure III-IV degree, shock, AV block II and III degree sinoatrial block, sick sinus syndrome, bradycardia, hypokalemia, hypotension, elongated the QT interval, occlusive peripheral arterial disease obstructive pulmonary disease, metabolic acidosis, laryngeal edema, allergic rhinitis.

Pregnancy and breast-feeding

Allowed only for health reasons (for 48-72 hours prior to delivery is recommended to stop taking).

Side effects

Headache, dizziness, drowsiness, fatigue, cold extremities; rarely - a violation of the digestive tract function, bronchospasm, skin reactions, insomnia, increased severity of heart failure, bradycardia, AV conduction disorders, hypotension; decrease in lacrimation, hypoglycemia, hallucinations, dry mouth, muscle cramps, transient impotence, violation of visual acuity, conjunctivitis.

Interaction

In combination with nifedipine, tricyclic antidepressants, barbiturates, phenothiazine derivatives, drugs, vasodilators, diuretics and other antihypertensive drugs cause a significant reduction, with noradrenaline and MAO inhibitors - a sharp increase in blood pressure. Drugs and anti-inflammatory drugs increase cardiodepressivny effect. Could enhance neuromuscular blockade against the backdrop of tubocurarine. Reserpine, clonidine, alpha-methyldopa, guanfacine, cardiac glycosides increase the severity of the negative chrono and dromotropic action. It increases the effect of insulin and oral hypoglycemic agents (especially against physical stress).

Dosing and Administration

Inside, the food with a small amount of water - 160 mg (1 tablet of 160 mg or 2 mg Table 80..), 2 times a day, or 80 mg (1 tablet of 80 mg.) 2-3 times a day; Cl patients with creatinine in the range 10-30 ml / min, the dose is reduced by half; Cl creatinine at least 10 ml / min 4.1 recommended use dosage. B / administered in a single dose of 20 mg, repeated administration is possible in 20 minutes.

Overdose

Symptoms: fatigue, dilated pupils, loss of consciousness, generalized myoclonic seizures, hypotension, bradycardia (with asystole), ventricular tachycardia (atypical), symptoms of cardiogenic and hypovolemic shock.

Treatment: removal of the drug from the body (gastric lavage, hemodialysis); atropine, dopamine, isoprenaline, adrenaline, glucagon indicated.

Precautionary measures

Not recommended simultaneous reception hinidinpodobnymi antiarrhythmic drugs. Be wary appoint diabetes, pheochromocytoma, disorders of the kidneys and liver, myocardial infarction (in history), psoriasis, in patients who are on a diet. abrupt discontinuation of treatment should be avoided (perhaps the "cancellation" syndrome).

Storage conditions

The temperature is not above 25 C.

Keep out of the reach of children.

Shelf life

80 mg tablets - 5 years.

160 mg Tablets - 5 years.

injection of 40 mg / ml 4 - 2 years.

Do not use beyond the expiration date printed on the package.

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