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Instruction for use: Cyanocobalamin solution for injections

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Dosage form: Solution for injection

Active substance: Cyanocobalaminum

ATX

B03BA01 Cyanocobalamin

Pharmacological groups:

Vitamins and vitamin-like remedies

Stimulators of hematopoiesis

The nosological classification (ICD-10)

D50 Iron deficiency anemia: Iron deficiency in food; Anemia due to violations of hemoglobin synthesis and iron metabolism; Anemia of iron deficiency; Iron / folic deficiency anemia; Iron deficiency anemia

D50.0 Iron deficiency anemia secondary due to loss of blood (chronic): Anemia posthemorrhagic; Anemia in chronic hemorrhage; Chronic blood loss in the digestive tract; Posthemorrhagic anemia

D51 Vitamin-B12-deficiency anemia: Vitamin-B12 deficiency anemia; Macrocytic vitamin-B12-deficiency anemia; Anemic pernitic

D52 Folic deficiency anemia: Folate deficiency anemia; Combined iron-folic-B12-deficient anemia; Macrocytic anemia; Iron / folic deficiency anemia

D64 Other anemia: Erythrocyte anemia; Erythroid hypoplastic anemia; Anemia due to erythropoietin deficiency; Anemia in metabolic disorders of erythrocytes; Anemia; Autoimmune anemia; Idiopathic anemia

E53 Insufficiency of other B vitamins B: Hypovitaminosis B; An additional source of B vitamins; The source of vitamin B group; Secondary deficiency of B-complex vitamins; Increased demand for B vitamins

E53.8.0 * Vitamin deficiency: Hypovitaminosis; Deficiency of iron and folic acid in pregnancy; Deficiency of folic acid; An additional source of folic acid during pregnancy; Folate deficiency; Increased need for folic acid; Folinic hypovitaminosis

E53.8.1 * Vitamin B12 deficiency: B12 hypovitaminosis; Insufficiency of cyanocobalamin; Secondary deficiency of B-complex vitamins; Combined iron-folic-B12-deficient anemia

G12.2 Motor neuron disease: Tropical spastic paraparesis; Amyotrophic lateral sclerosis; Bulbar Pallas; Bulbar palsy; Amyotrophic lateral sclerosis; Diseases of motor neurons; Amyotrophic lateral sclerosis; Low-Gehrig's disease;Charcot's disease; Amyotrophic amyotrophic sclerosis; Sclerosis lateral primary; Progressive pseudobulbar palsy; Progressive bulbar palsy; Primary lateral sclerosis

G35 Multiple Sclerosis: Disseminated Sclerosis; Multiple sclerosis; Recurrent multiple sclerosis; Secondary-progressive multiple sclerosis; Exacerbation of multiple sclerosis; Mixed forms of multiple sclerosis

G50 Lesions of the trigeminal nerve

G54.1 Lesions of the lumbosacral plexus: Lumbosacral radiculitis; Neuralgia of radicular origin; Pathology of the spine; Radiculitis of the lumbosacral; Radiculoneuritis

G60-G64 Polyneuropathies and other disorders of the peripheral nervous system

G80 Cerebral Palsy: Cerebral Palsy; Children's cerebral palsy

G95.9 Disease of spinal cord, unspecified: Degenerative disease of spinal cord; Myelopathy funicular; Spinal spastic syndrome; Acquired spinal cord disease; Congenital diseases of the spinal cord

K73 Chronic hepatitis, not elsewhere classified: Inflammatory liver disease; Hepatitis autoimmune; Hepatitis chronic; Infection of the liver; Chronic hepatitis with signs of cholestasis; Chronic reactive hepatitis; Chronic persistent hepatitis; Chronic infectious hepatitis; Chronic active hepatitis; Chronic inflammatory liver disease; Autoimmune Hepatitis; Chronic hepatitis is aggressive

K74 Fibrosis and cirrhosis of the liver: Edematous-ascitic syndrome in cirrhosis; Inflammatory liver disease; Pretsirroticheskoe state; Cystic fibrosis of the liver; Cirrhotic and pretsirroticheskoe state; Cirrhosis portal hypertension c; Cirrhosis of the liver with signs of portal hypertension; Cirrhosis of the liver with portal hypertension and edema-ascites syndrome; Cirrhosis of the liver with portal hypertension; Liver cirrhosis with ascites and edema; Liver cirrhosis with ascites; cirrhotic ascites

M79.2 Neuralgia and neuritis, unspecified: Pain syndrome with neuralgia; Brachialgia; Occipital and intercostal neuralgia; Neuralgia; Neuralgic pain; Neuralgia of intercostal nerves; Neuralgia of the posterior tibial nerve; Neuritis; Neuritis traumatic; Neurological Pain Syndromes; Neurological contractures with spasms; Acute neuritis; Peripheral neuritis; Post-traumatic neuralgia; Severe pain of a neurogenic nature; Chronic neuritis; Essential neuralgia

Q90 Down's syndrome: Mongolism; Monkey wrinkle; Trisomy 21; Trisomy G; Mosaicism in patients with Down syndrome

R68.8 Other specified general symptoms and signs: Toxemia

Composition and release form

1 ml solution for injection contains cyanocobalamin (vitamin B12) 30, 100, 200 or 500 mkg; in a cardboard box 10 pcs.

Pharmachologic effect

Mode of action - Hematopoietic, metabolic, replenishing vitamin B12 deficiency.

In the form of dimethylbenzimidazole-deoxyadienyl-cobalt is included in the reductase and participates in the transfer of methyl fragments, the formation of choline, myelin, methionine, nucleic acids, etc.).

Indication of the drug Cyanocobalamin solution for injections

Anemia (Addison-Birmer, alimentary macrocytic, iron-deficient, post-hemorrhagic, aplastic, caused by toxic substances and medicines), liver cirrhosis, hepatitis, myelosis, polyneuritis, radiculitis, trigeminal neuralgia, amyotrophic lateral sclerosis, cerebral palsy, multiple sclerosis, disease Down, peripheral nerve injuries, skin diseases.

Contraindications

Thromboembolism, angina pectoris.

Side effects

Excitation, pain in the heart, tachycardia, allergic reactions.

Interaction

Incompatible (in one syringe) with thiamine bromide, riboflavin.

Dosing and Administration

SC, IM, IV and intralumbar; At an Addison-Birmer anemia - on 100-200 mkg every other day; With Addison-Birmer anemia with funicular myelosis and macrocytic anemia with nervous system disorders - 500 μg or more per injection (in the first week - daily, then - with intervals between administrations up to 5-7 days), concomitantly prescribe folic acid.

In the period of remission, in the absence of the phenomena of funicular myelosis, 100 micrograms are administered twice a month for maintenance therapy, and 200-400 micrograms 2-4 times a month in the presence of neurologic events.

With iron deficiency and posthemorrhagic anemia - 30-100 mcg 2-3 times a week; At aplastic anemia (especially in children) - 100 mcg before the onset of clinico-hematologic improvement; With alimentary anemia in children at an early age and in premature infants - 30 mcg / day for 15 days; In diseases of the central nervous system and neurological diseases with pain syndrome are administered in increasing doses from 200 to 500 μg per injection, and with improvement of the condition - 100 μg / day, the course - up to 2 weeks; With traumatic lesions of peripheral nerves - 200-400 mcg every other day for 40-45 days; With hepatitis and cirrhosis of the liver - 30-60 mcg per day or 100 mcg every other day for 25-40 days; With dystrophy in young children, Down's disease and cerebral palsy - 15-30 mcg every other day; With funicular myelosis, amyotrophic lateral sclerosis, multiple sclerosis, sometimes injected into the spinal canal for 15-30 mcg (increasing gradually the dose to 200-250 mcg).

Storage conditions of the drug Cyanocobalamin solution for injections

In the dark place.

Keep out of the reach of children.

Shelf life of the drug Cyanocobalamin solution for injections

2 years.

Do not use after the expiry date printed on the package.

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