Instruction for use: Contac 400

Active substance Chlorphenamine + Phenylpropanolamine

ATX Code R01BA51 Phenylpropanolamine in combination with other drugs

Pharmacotherapeutic group:

Alpha-adrenoceptor agonists in combination

H1-antihistamines in combination

Decongestant combinations in

The nosological classification (ICD-10)

J00 Acute nasopharyngitis [runny nose]

Viral rhinitis, Inflammation of the nasopharynx, Inflammatory diseases of the nose, purulent rhinitis, Nasal congestion, Nasal congestion with colds and flu, The difficulty of nasal breathing, The difficulty of nasal breathing for colds, Difficulty in nasal breathing, Difficulty in nasal breathing in colds, nasal, hypersecretion, cold, ARI with rhinitis phenomena, coryza, Acute rhinitis of various origins, Acute rhinitis with thick purulent mucous exudate, Acute nasopharyngitis, Swelling of the mucosa of the nasopharynx, Rhinitis, rhinorrhea, Infectious-inflammatory diseases of ENT organs, heavy cold, rhinopharyngitis, nasopharyngitis

J01 Acute sinusitis

Inflammation of the sinuses, Inflammatory diseases of the paranasal sinuses, Purulent inflammation of the paranasal sinuses, Infectious-inflammatory diseases of ENT organs, Infection of the sinuses, Combined sinusitis, Exacerbation of sinusitis, Acute inflammation of the paranasal sinuses, Acute bacterial sinusitis, Acute sinusitis in adults, Subacute sinusitis, acute Sinusitis, sinusitis

J30.0 Vasomotor rhinitis

Rhinitis chronic vasomotor neurovegetative

Structure and Composition

1 capsule contains 50 mg of phenylpropanolamine hydrochloride and chlorpheniramine maleate 4 mg; in blister 6 pcs., in box 1 blister.

pharmachologic effect

pharmacological effect - decongestant, antihistamine, sympathomimetic.

Blocks histamine H1- and m-cholinergic receptors, enhances peripheral sympathetic impulses.

pharmacodynamics

It eases symptoms of rhinitis and sinusitis of different etiologies. It reduces allergic reactions.

Pharmacokinetics

Phenylpropanolamine easily and rapidly absorbed from the gastrointestinal tract, excreted largely unchanged. Chlorpheniramine is readily absorbed and distributed in the tissues, almost 70% bound to plasma proteins. It is metabolized in the liver. Excreted in the urine as metabolites - dimetilhlorfeniramina and didesmetilhlorfeniramina and partially unchanged.

Indications

Strong runny nose, nasal congestion, colds and flu, hay fever, sinusitis.

Contraindications

Hypersensitivity, arterial hypertension, pheochromocytoma, thyrotoxicosis, diabetes mellitus, heart failure, children's age (12 years).

Pregnancy and breast-feeding

Acceptable, but only on prescription.

Side effects

Headache, sleepiness, psychomotor disturbances, dry mouth, gastrointestinal disorders, urinary retention, accommodation paresis, photosensitivity, skin rash.

Interaction

Sympathomimetic effect (a sharp rise in blood pressure) increase tricyclic antidepressants, beta-blockers, MAO inhibitors, hypnotic - alcohol, anxiolytics and hypnotics, side - m-anticholinergics.

Dosage and Administration

Inside (not liquid, squeezed small amount of liquid), in adults and children over 12 years - 1 capsule. 2 times a day (morning and evening before bedtime).

Overdose

Symptoms - drowsiness, dry mouth, dizziness, nausea, irritability, headache, increased blood pressure, tachycardia, arrhythmia, seizures.

Treatment - aspirated stomach contents and washed; activated charcoal and a laxative salt; forced acid diuresis.

Precautionary measures

Not recommended combination with other medicines containing decongestants. Do not drive a car and operate machines and potentially dangerous machinery. In the course of treatment can not drink alcohol.

Storage conditions

In a dry, the dark place at a temperature no higher than 30 ° C.

Keep out of the reach of children.

The shelf life

5 years.

Do not use beyond the expiration date printed on the package.