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Instruction for use: Comb-insulin S

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ATX Code A10AD01 Human insulin

Active substance Insulin biphasic [human semisynthetic]

Pharmacological group


Nosological classification (ICD-10)Z31.1 Artificial insemination

E10 Insulin-dependent diabetes mellitus

Decompensation of carbohydrate metabolism, Diabetes mellitus, Diabetes insulin sugar, Diabetes mellitus type 1, Diabetic ketoacidosis, Insulin-dependent diabetes, Insulin-dependent diabetes mellitus, Coma hyperosmolar non-ketoacidotic, Labile form of diabetes mellitus, Violation of carbohydrate metabolism, Type 1 diabetes mellitus, Type I diabetes mellitus, Insulin-dependent diabetes mellitus, Type 1 diabetes mellitus

E11 Non-insulin-dependent diabetes mellitus

Acetonuric diabetes, Decompensation of carbohydrate metabolism, Diabetes insulin-independent sugar, Diabetes sugar type 2, Type 2 Diabetes, Non-insulin-dependent diabetes, Non-insulin dependent diabetes mellitus, Non-insulin-dependent diabetes mellitus, Insulin resistance, Insulin resistant diabetes mellitus, Coma lactobacillus diabetic, Violation of carbohydrate metabolism, Type 2 diabetes mellitus, Diabetes mellitus type II, Diabetes mellitus in adulthood, Diabetes mellitus in old age, Diabetes insulin-independent, Diabetes mellitus type 2, Sugar insulin-independent diabetes type II

Composition and form of release

1 ml of the suspension for injection contains 40 IU of chromatographically pure porcine insulin and 0.111 mg of the aminocinuride dihydrochloride depot medium; In bottles of 10 ml, in a box of 5 pcs.


Rapid-acting insulin medication of medium duration.

pharmachologic effect

Pharmacological action - hypoglycemic.

Eliminates the deficiency of endogenous insulin.


It lowers the level of glucose in the blood, increases its absorption by tissues, enhances lipogenesis and glycogenogenesis, protein synthesis, reduces the rate of glucose production by the liver.


Diabetes mellitus type I. Diabetes mellitus type II with resistance to oral hypoglycemic drugs, intercurrent diseases, before and after surgery.


Hypersensitivity, hypoglycemia.

pregnancy and lactation

Not recommended (use human insulin).

Side effects

Hypoglycemia, hypoglycemic precoma and coma, immunological cross reactions with human insulin, lipodystrophy (with prolonged use), allergic reactions.

Dosing and Administration

SC (in exceptional cases - in / m). The site of the injection is changed at each injection. The initial dose for adults is 8-24 IU, single dose should not exceed 40 IU. When switching from insulin-C to Comb-insulin C, the daily dose decreases 4-fold.

Storage Conditions

In a dry, cool place, at a temperature of 2-8 C (do not freeze).

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiry date printed on the package.

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