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Instruction for use: Cognitiv

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Dosage form: coated tablets

Active substance: Selegiline*


N04BD01 Selegiline

Pharmacological groups:



The nosological classification (ICD-10)

G20 Parkinson's disease: A trembling paralysis; Idiopathic Parkinsonism; Parkinson's disease; Symptomatic Parkinsonism

G21 Secondary Parkinsonism: Medicinal Parkinsonism; Parkinsonism; Parkinsonism symptomatic; Disorders of extrapyramidal system; Parkinson's Syndrome

Composition and release form

1 tablet, coated, contains selegiline hydrochloride 5 or 10 mg; In a blister 10 pcs., In a box of 5 and 10 blisters.

Pharmachologic effect

Mode of action - antiparkinsonian.

Selectively blocks MAO B, inhibits the metabolism of dopamine and increases its concentration in the extrapyramidal system.


Quickly and almost completely absorbed from the digestive tract. Cmax is achieved in a short time. It binds to plasma proteins by 94%. Easily passes the histohematological barriers, including BBB, and accumulates in tissues rich in lipids.

Indication of the drug Cognitiv

Parkinson's disease, Parkinsonism.


Hypersensitivity, extrapyramidal disorders not associated with dopamine deficiency (essential tremor, Huntington's chorea), gastric and duodenal ulcer.

Side effects

In combination with levodopa - dizziness, headache, agitation, insomnia, fatigue, dyskinesia, hyperkinesia, hypotension, swelling, hyperhidrosis, dry mouth, nausea, constipation; Rarely - anxiety, confusion, psychosis, dysuria, shortness of breath, skin rash; Extremely rare - increased levels of hepatic enzymes, arterial hypertension, arrhythmia, relapses of stomach ulcers.


Incompatible with fluoxetine, sympathomimetics, drugs, depressing central nervous system, alcohol. Efficacy increases levodopa (in combination with peripheral inhibitors of decarboxylase). Amantadine and anticholinergic drugs increase the incidence of adverse reactions.

Dosing and Administration

Inside, not liquid, squeezed a small amount of liquid.

Cognitiv 5 mg: 1-2 tablets. In the morning (after breakfast) or 1 table. After breakfast and 1 table. after lunch.

Cognitiv 10 mg: 1 table. In the morning (after breakfast). The maximum dose is 10 mg.

With combined therapy with levodopa, the dosage of the latter can be reduced by 10-30% in the first 2-3 days.

Precautionary measures

Do not prescribe to patients receiving antidepressant drugs (tricyclic, fluoxetine). It should not be combined with levodopa with arterial hypertension, thyrotoxicosis, pheochromocytoma, narrow-angle glaucoma, prostate adenoma, tachyarrhythmia, severe angina, psychosis, dementia (progressive). Do not use during work drivers of vehicles and people whose profession is associated with increased concentration of attention.

Storage conditions of the drug Cognitiv

At a temperature not higher than 25 C

Keep out of the reach of children.

Shelf life of the drug Cognitiv

3 years.

Do not use after the expiry date printed on the package.

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