Instruction for use: Bufferin

Active substance Acetylsalicylic acid

ATX code N02BA01 Acetylsalicylic acid

Pharmacological group

NSAIDs - Salicylic acid derivatives

Nosological classification (ICD-10)

I21 Acute myocardial infarction

Myocardial infarction in the acute phase, Acute Myocardial Infarction, Myocardial infarction with pathologic Q wave and without, Myocardial infarction complicated by cardiogenic shock, Infarction left ventricular, Transmural myocardial infarction, Myocardial infarction netransmuralny (subendocardial), Netransmuralny myocardial infarction, Subendocardial myocardial infarction, The acute phase of myocardial infarction, Acute myocardial infarction, Sub-acute phase of myocardial infarction, Subacute phase of myocardial infarction, Thrombosis of the coronary arteries (the arteries), Threatened myocardial infarction, Myocardial infarction without Q wave

I74 Embolism and arterial thrombosis

Thrombosis of effort (tension), Arterial thrombosis, Arteriothrombosis, Subacute and chronic arterial thrombosis, Subacute thrombosis of peripheral arteries, Postoperative thrombosis, Vascular thrombosis, Vascular embolism, Thrombosis of aortocoronary shunt, Arterial thrombosis, Thrombosis of arteries, Coronary artery thrombosis, Coronary thrombosis, Thrombosis of blood vessels, Thrombosis with ischemic stroke, Thrombosis with general surgical operations, Thrombosis in Oncology Operations, Vascular thrombosis, Thrombus formation in the postoperative period, Thrombotic complications. Thromboembolic diseases, Thromboembolic complications, Thromboembolic syndrome, Thromboembolic complication, Thromboembolic complication in the postoperative period, Thromboembolism of arteries, Partial vascular thrombosis, Embolism, Embolism of arteries

I82 Embolism and thrombosis of other veins

Recurrent venous thrombosis, Postoperative thrombosis, Venous thrombosis, Acute venous thromboembolism, Recurrent vein thrombosis, Thrombosis of veins, Thrombosis of veins of internal organs, Venous thrombosis, Deep vein thrombosis, Thrombosis of blood vessels, Vascular thrombosis, Thrombosis of veins, Deep vein thrombosis, Thromboembolic diseases, Thromboembolism of veins, Severe venous thrombosis, Embolism, Embolism of veins, Thromboembolic complications

M05 Seropositive rheumatoid arthritis

Rheumatoid arthritis seropositive

M79.0 Other unspecified rheumatism

Degenerative rheumatic disease, Degenerative and rheumatic diseases of the tendons, Degenerative rheumatic diseases, Localized forms of rheumatism of soft tissues, Rheumatism, Rheumatism with a pronounced allergic component, Rheumatism of the articular and extraarticular, Rheumatic attack, Rheumatic complaints, Rheumatic diseases, Rheumatic disease of the spine, Relapses of rheumatism, Articular and extra-articular rheumatism, Articular and muscular rheumatism, Articular rheumatism, Articular syndrome with rheumatism, Chronic rheumatic pain, Chronic articular rheumatism, Rheumatoid diseases, Rheumatic diseases of the intervertebral disc

M79.1 Myalgia

Myofascial pain syndromes ,Pain syndrome in musculo-articular diseases, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the muscles, Tenderness of muscles, Muscular soreness in severe physical exertion, Painful conditions of the musculoskeletal system, Pain in the musculoskeletal system, Pain in the muscles, Pain at rest, Muscle aches, Muscle pain, Musculoskeletal pain, Myalgia, Muscle pain, Muscle pain at rest, Muscle pain, Muscular pain of non-rheumatic origin, Muscle pain of rheumatic origin, Acute muscle pain, Rheumatic pain, Rheumatic pains, Myofascial syndrome, Fibromyalgia

M79.2 Neurology and neuritis, unspecified

Pain syndrome with neuralgia, Brachialgia, Occipital and intercostal neuralgia, Neuralgia, Neuralgic pain, Neuralgia, Neuralgia of intercostal nerves,Neuralgia of the posterior tibial nerve, Neuritis, Neuritis traumatic, Neuritis, Neurological Pain Syndromes, Neurological contractures with spasms, Acute neuritis, Peripheral neuritis,Post-traumatic neuralgia,Severe pain of a neurogenic nature, Chronic neuritis, Essential neuralgia

R07.2 Pain in the heart

neuroses of the heart, Myocardial ischemic pain, Pain syndrome in myocardial infarction, cardialgia, cardioneurosis, Cardiac syndrome, Pain in cardiac patients, Cardialgia on background dyshormonal myocardial dystrophy, Functional cardialgia, Psevdostenokardiya, pericardial pain

R50 Fever of unknown origin

Malignant hyperthermia, Hyperthermia malignant

R51 Headache

Pain in the head, Cephalgia, Pain with sinusitis, Pain in the back of the head, Painful headache, Headache of vasomotor genesis, Headache of vasomotor origin, Headache with vasomotor disorders, Headache, Neurological headache, Serial headache

R52.2 Other constant pain

Pain syndrome, rheumatic origin, Pain at vertebral lesions, Pain in the chamber, Pain for burns, Pain syndrome weak or moderate, Perioperative pain,Moderate to severe pain, Moderately or weakly expressed pain syndrome, Moderate to severe pain, Ear pain of otitis, Neuropathic pain, neuropathic pain

Composition and form of release

1 tablet "buffer" contains acetylsalicylic acid 325 or 500 mg.

pharmachologic effect

Pharmacological action - anti-inflammatory, antipyretic, analgesic.

Inhibits the synthesis of PG.

Pharmacodynamics

Reduces the aggregation of platelets, in a large dose (6 g / day) inhibits the synthesis of prothrombin in the liver and increases prothrombin time.

Indication

Rheumatism, rheumatoid arthritis, infectious-allergic myocarditis; fever in infectious and inflammatory diseases, pain syndrome of mild and moderate intensity (neuralgia, myalgia, headache), thrombosis and embolism (prevention), myocardial infarction (prophylaxis).

Contraindications

Hypersensitivity, erosive-ulcerative lesions of the gastrointestinal tract in the exacerbation phase, aspirin asthma, urticaria, rhinitis (in the treatment of NSAIDs (nonsteroidal anti-inflammatory drugs) in history), hemophilia, hemorrhagic diathesis, hypoprothrombinemia, vitamin K, marked disorders kidney function, children's age (up to 2 years).

pregnancy and lactation

Contraindicated in the first and last trimesters of pregnancy. It is excreted in breast milk and increases the risk of bleeding in a child.

Side effects

Nausea, anorexia, epigastric pain, diarrhea, erosive and ulcerative lesions and bleeding in the gastrointestinal tract, allergic reactions (skin rash, Quincke's edema, bronchospasm), violations of the liver and kidney function, thrombocytopenia. With prolonged use - dizziness, headache, reversible vision impairment, tinnitus, vomiting, rheology and blood clotting.

Interaction

Enhances the effect of heparin, oral anticoagulants and antidiabetics. It is not recommended to combine with other NSAIDs.

Dosing and Administration

Inside, with rheumatism: adults in a daily dose of 5-8 g and 100-125 mg / kg of body weight for children, 4-5 times a day. After 1-2 weeks, the dose of children is reduced to 60-70 mg / kg per day. The course for children and adults - 6 weeks.

With fever and pain syndrome: adults 0.25 (0.325) - 1.0 (0.65) g 4-6 times a day, children - 10-15 mg / kg to 5 times a day. The course is no more than 2 weeks.

For the prevention of thrombosis and embolism - 0.5 g 2-3 times a day (or 0.65 g 2 times a day).

To improve the rheological properties of blood - 0.25 g per day for several months.

Precautionary measures

With caution appoint patients with liver disease, gout, erosive-ulcerative lesions and bleeding in the gastrointestinal tract in anamnesis; dyspeptic symptoms.

storage Conditions

Keep out of the reach of children.