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Instructions

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Instruction for use: Brinsulmidi H 40 IU/ml

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ATX CodeA10AC Medium-acting insulins and their analogs for injectable administration

Active substance Cetrorelix Insulin biphasic [human biosynthetic]

Pharmacological group

Insulins

Nosological classification (ICD-10)Z31.1 Artificial insemination

E14 Unspecified diabetes mellitus

Severe vascular complication of diabetes, Diabetes, Diabetic asthenia, Thyroid dysfunction, Diabetes,Obesity in the background of diabetes

Composition and form of release

1 ml of the suspension for injection contains insulin zinc-suspension of human 40 ED, as well as methyl parahydroxybenzoate, sodium acetate, sodium chloride, zinc acetate and water for injection; In glass bottles of 10 ml, in a cardboard bundle 1 bottle.

Characteristic

Semisynthetic monocomponent human insulin containing 30% amorphous and 70% crystalline insulin. The suspension is white, when standing, it stratifies to form a white precipitate, the liquid above the precipitate is transparent colorless or almost colorless, the precipitate is easily resuspended by shaking.

pharmachologic effect

Pharmacological action - hypoglycemic.

It lowers the level of glucose in the blood, increases its absorption by tissues, activates glycogenogenesis, synthesis of protein and lipids, inhibits lipolysis, glycogenolysis and conversion of amino acids into glucose.

Clinical Pharmacology

The preparation of insulin of average duration of action. The effect develops 2.5 hours after the SC administration, reaches a maximum in the range of 7-15 hours and lasts for 24 hours.

Indications

Diabetes mellitus (type 1) in adults, diabetes mellitus (type 2) (in the case of resistance to oral hypoglycemic drugs, including partial for combination therapy, against intercurrent diseases, during pregnancy).

Contraindications

Hypersensitivity, hypoglycemia.

Side effects

Hypoglycemia, allergic reactions (skin rash, rarely - angioedema); Hyperemia, itching, lipodystrophy (with prolonged use) at the injection site.

Interaction

MAO inhibitors, non-selective beta-blockers, sulfonamides, anabolic steroids, tetracyclines, clofibrate, cyclophosphamide, fenfluramine and preparations containing ethanol increase hypoglycemic effect; Oral contraceptives, glucocorticoids, thyroid hormones, thiazide diuretics, heparin, lithium preparations and tricyclic antidepressants - weaken. Reserpine and salicylates can both weaken and enhance hypoglycemic action.

Dosing and Administration

P / to, 1-2 times a day, the dose is determined individually, before use, the bottle is gently shaken. The drug must be entered immediately after typing in the syringe. A daily dose exceeding 0.6 U / kg should be given as two injections in different areas of the body.

Overdose

Symptoms: a sharp increase in sweating, tachycardia, tremor, hunger, agitation, paresthesia in the mouth, pallor of the skin, headache; In severe cases - hypoglycemic coma.

Treatment: ingestion of sugar or foods rich in carbohydrates; In severe cases, when the patient lost consciousness - the introduction of glucose (40% solution iv) and glucagon (IM).

special instructions

Patients receiving more than 100 units / day Brinsulmidi Ch, when changing the drug, it is advisable to hospitalize.

The transition from one type of insulin to another should be carried out under the control of blood glucose.

At primary appointment, change of a kind of insulin or occurrence during treatment of stressful situations the ability to control vehicles and mechanisms, to other potentially dangerous kinds of activity requiring attention and speed of reaction is possible.

When changing the nature and diet, significant physical exertion, infectious diseases, surgical interventions, pregnancy, thyroid dysfunction, Addison's disease, hypopituitarism, renal insufficiency, and in patients older than 65 years, the dosage should be adjusted.

Insulin lowers tolerance to alcohol.

If you need to take any medicine, you should consult your doctor.

storage Conditions

In the dark place at a temperature of 2-8 ° C. Do not freeze.

Keep out of the reach of children.

Shelf life

2.5 years.

Do not use after the expiry date printed on the package.

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