Instruction for use: Berlinsulin H Normal U-40

ATX Code A10AB01 Insulin human

Active substance Insulin soluble [human biosynthetic]

Pharmacological group

insulins

Nosological classification (ICD-10)Z31.1 Artificial insemination

E10 Insulin-dependent diabetes mellitus

Decompensation of carbohydrate metabolism, Diabetes mellitus, Diabetes insulin sugar, Diabetes mellitus type 1, Diabetic ketoacidosis, Insulin-dependent diabetes, Insulin-dependent diabetes mellitus, Coma hyperosmolar non-ketoacidotic, Labile form of diabetes mellitus, Violation of carbohydrate metabolism, Type 1 diabetes mellitus, Type I diabetes mellitus, Insulin-dependent diabetes mellitus, Type 1 diabetes mellitus

E11 Non-insulin-dependent diabetes mellitus

Acetonuric diabetes, Decompensation of carbohydrate metabolism, Diabetes insulin-independent sugar, Diabetes sugar type 2, Type 2 Diabetes, Non-insulin-dependent diabetes, Non-insulin dependent diabetes mellitus, Non-insulin-dependent diabetes mellitus, Insulin resistance, Insulin resistant diabetes mellitus, Coma lactobacillus diabetic, Violation of carbohydrate metabolism, Type 2 diabetes mellitus, Diabetes mellitus type II, Diabetes mellitus in adulthood, Diabetes mellitus in old age, Diabetes insulin-independent, Diabetes mellitus type 2, Sugar insulin-independent diabetes type II

Composition and form of release

1 ml of solution for injection contains human insulin 40 U; In bottles of 10 ml, in a box of 1 pc.

pharmachologiceffect

Pharmacological action - hypoglycemic.

It interacts with a specific receptor of the plasma membrane and penetrates into the cell, where it activates protein phosphorylation, stimulates glycogen synthase, pyruvate dehydrogenase, hexokinase, inhibits fat lipase and lipoprotein lipase. In combination with a specific receptor facilitates the penetration of glucose into cells, enhances digestion and promotes its conversion into glycogen. Increases the glycogen reserve in muscles, stimulates the synthesis of peptides.

ClinicalPharmacology

It is a preparation of quick and short action. The maximum effect develops in 1-3 hours and lasts 6-8 hours.

Indications

Diabetes mellitus type I and II (all forms), diabetic coma.

Contraindications

Hypersensitivity (relative contraindication), hypoglycemia.

Sideeffects

Hypoglycemia, lipodystrophy and reddening of the skin at the injection site, allergic reactions.

Dosing and Administration

The dosage is set individually. Usually, they are administered SC (in special cases - IM) for 10-15 minutes before meals 3-4 times a day. Single dose is 6-20 units. In patients with diabetes mellitus with increased sensitivity to insulin and in children, this dose is reduced, in patients with insensitivity to insulin - increase. With a diabetic coma, first Bersulinulin H Normal U-40 is administered iv in the dose at the rate of 0.1-0.3 U / kg, then a prolonged IV infusion at a rate of 0.1-0.2 U / kg per hour.

storage Conditions

In a cool place, at a temperature of 2-8 ° C (do not freeze).

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the expiry date printed on the package.