Instruction for use: Berlinsulin H Bazal pen

ATX Code A10AB01 Human insulin

Active substance: Insulin-isophan [human semisynthetic]

Pharmacological group

Insulins

Nosological classification (ICD-10)

E10 Insulin-dependent diabetes mellitus

Decompensation of carbohydrate metabolism, Diabetes mellitus, Diabetes insulin sugar, Diabetes mellitus type 1, Diabetic ketoacidosis, Insulin-dependent diabetes, Insulin-dependent diabetes mellitus, Coma hyperosmolar non-ketoacidotic, Labile form of diabetes mellitus, Violation of carbohydrate metabolism, Type 1 diabetes mellitus, Type I diabetes mellitus, Insulin-dependent diabetes mellitus, Type 1 diabetes mellitus

E11 Non-insulin-dependent diabetes mellitus

Acetonuric diabetes, Decompensation of carbohydrate metabolism, Diabetes insulin-independent sugar, Diabetes sugar type 2, Type 2 Diabetes, Non-insulin-dependent diabetes, Non-insulin dependent diabetes mellitus, Non-insulin-dependent diabetes mellitus, Insulin resistance, Insulin resistant diabetes mellitus, Coma lactobacillus diabetic, Violation of carbohydrate metabolism, Type 2 diabetes mellitus, Diabetes mellitus type II, Diabetes mellitus in adulthood, Diabetes mellitus in old age, Diabetes insulin-independent, Diabetes mellitus type 2, Sugar insulin-independent diabetes type II

Composition and form of release

1 ml of the suspension for injection contains insulin of human 100 ED and protamine sulfate 0.35 mg (corresponding to 0.27 mg of protamine base) (isophane-insulin); In cartridges of 1.5 ml, in a box of 5 pcs.

pharmachologic effect

Pharmacological action - hypoglycemic.

It interacts with a specific receptor of the plasma membrane and penetrates into the cell, where it activates protein phosphorylation, stimulates glycogen synthase, pyruvate dehydrogenase, hexokinase, inhibits fat lipase and lipoprotein lipase. In combination with a specific receptor facilitates the penetration of glucose into cells, enhances the absorption of tissues and promotes its conversion into glycogen. Increases the glycogen reserve in muscles, stimulates the synthesis of peptides.

Clinical Pharmacology

It is a drug with a delayed initial effect and an average duration of action. The maximum effect is manifested after 2-10 h after administration, the effect is maintained for 18-20 h.

indications

All forms of diabetes mellitus (type I and II), intolerance to other insulin preparations.

Contraindications

Hypoglycaemia, immediate type hypersensitivity (relative contraindication); In / in the appointment.

Side effects

Hypoglycemia (up to coma), changes in water content in the lens, lipodystrophy, hyperemia (at the injection site), allergic reactions.

Dosing and Administration

Enter s / k for 30-45 minutes before the first breakfast and before dinner. With each injection, the injection site is changed. Usually the daily dose is given in the form of 1-2 injections. If a single dose for a single injection exceeds 50 units, then go to the mode of 2-time administration.

Precautionary measures

With increased sensitivity to insulin of animal origin, it is necessary to check the tolerability of human insulin (skin test). With an allergic reaction of an immediate type to protamine sulfate, it is recommended to switch to insulin that does not contain protamine. Cartridges with insulin have been developed specifically for use in the syringe pen "B-D-Pen". It is necessary to carefully follow the instructions for using this device for injecting insulin, relating to refilling the cartridge with insulin, as well as preparation and injection. Cartridges with insulin should not be refilled. They can not also be used for the preparation of mixtures of insulins. If the cartridge with insulin from the injection device is removed, it is not allowed to insert it again.

storage Conditions

In a cool place at a temperature of 2-8 ° C (do not freeze). In a cool place, at a temperature of 2-8 ° C, protect from freezing. After the cartridge is inserted into the injection device - in a place protected from direct sunlight, at temperatures below 30 ° C (but not in the refrigerator).

Keep out of the reach of children.

Shelf life

2 years. After the cartridge is inserted into the injection device - 21 days.

Do not use after the expiry date printed on the package.