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Instruction for use: Arthrex

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Active substance Diclofenac

ATX Code M02A15 Diclofenac

Pharmacological group

NSAIDs - Acetic acid derivatives and related compounds in combinations

Nosological classification (ICD-10)

R68.8 Other specified general symptoms and signs


T08-T14 Injuries to unspecified part of trunk, limb or body region

Composition and form of release

Gel containing 1% diclofenac sodium; in tubes of 50 and 100 g.

pharmachologic effect

Pharmacological action - anti-inflammatory, antipyretic, analgesic.

Anti-inflammatory (inhibition of cyclooxygenase), analgesic, antipyretic.


When applied locally, it penetrates through the skin and accumulates in therapeutic concentrations at the site of action. The doses administered in the form of 1% gel are comparable to the usual daily doses for oral administration. For the therapeutic effect of the drug, the concentration created at the site of action is more important than its concentration in the plasma. Comparison of the excretion of the drug and its metabolites with ingestion and topical application showed that almost the same metabolites are released.

Clinical Pharmacology

Due to local application, it is possible to avoid the systemic load that occurs when taking the drug inside or with its parenteral administration.


Injuries to tendons, ligaments, muscles and joints (to relieve pain and inflammation during sprains, dislocations, bruises), localized forms of soft tissue rheumatism (pain and inflammation removal).


Hypersensitivity (including other non-steroidal anti-inflammatory drugs), age (up to 6 years).

pregnancy and lactation

It is not recommended during pregnancy and lactation due to the lack of clinical data.

Side effects

Local allergic reactions (exanthema, erosion, erythema, eczema, ulceration), photosensitization; possible the development of systemic side effects.

Dosing and Administration

Rub into the skin from 2 to 4 g of gel (corresponding to 2-2.5 cm of the squeezed strip of gel) 2-4 times a day. After applying the product, wash your hands. the drug penetrates through the skin.


It is most likely when the drug enters the digestive tract. Treatment: gastric lavage, administration of activated charcoal; symptomatic therapy aimed at eliminating: increased blood pressure, impaired renal function, seizures, gastrointestinal irritation, respiratory depression. Specific therapy (forced diuresis, hemodialysis, hemoperfusion) is ineffective, tk. Non-steroidal anti-inflammatory drugs quickly bind to proteins and undergo intensive metabolism.

Precautionary measures

Do not apply to damaged areas of the skin, to open wounds or in combination with an occlusive dressing. Avoid contact with eyes and mucous membranes. Patients with senile age should be administered cautiously (a tendency to side reactions). When developing adverse reactions about them, it is necessary to inform the doctor.

storage Conditions

At a temperature of no higher than 25 C.

Keep out of the reach of children.

Shelf life

5 years.

Do not use after the expiry date printed on the package.

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