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Instruction for use: Amitriptyline-Ferein

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Dosage form: film coated tablets

Active substance: Amitriptyline*


N06AA09 Amitriptyline

Pharmacological group:


The nosological classification (ICD-10)

F32 Depressive episode: Adynamic subdepression; Astheno-adynamic subdepressive states; Asthenodepressive disorder; Astheno-depressive disorder; Asthenodepressive state; Astheno-depressive state; Major Depressive Disorder; Vyaloapatichesky depression with retardation; Double depression; Depressive pseudodement; Depressive illness; Depressive mood disorder; Depressive disorder; Depressive mood disorder; Depressive state; Depressive disorders; Depressive syndrome; Depressive syndrome larviated; Depressive syndrome with psychoses; Depressed masks; Depression; Depression Depletion; Depression with the phenomena of inhibition within the framework of cyclothymia; Depression is smiling; Involutional depression; Involutionary melancholy; Involutional depression; Manic-depressive disorder; Masked Depression; Melancholic Attack; Neurotic depression; Neurotic depression; Shallow Depression; Organic depression; Organic depressive syndrome; Simple depression; Simple melancholic syndrome; Psychogenic depression; Reactive depression; Reactive depression with moderate psychopathological symptoms; Reactive depressive states; Reactive depression; Recurrent depression; Seasonal depressive syndrome; Severostatic depression; Senile Depression; Senile Depression; Symptomatic Depression; Somatogenic depression; Cyclotymic depression; Exogenous Depression; Endogenous depression; Endogenous Depressive Conditions; Endogenous Depression; Endogenous depressive syndrome

F50.0 Anorexia nervosa: Anorexia nervosa syndrome; Anorexia nervosa; Anorexia nervously-psychical; Cachexia nervy; Psychogenic anorexia

F60.3 Emotionally unstable personality disorder: Mood swings; Mental lability; Emotional fence; Emotional detachment; Mood Change; Lability of mood; Instability of emotional background; Mixed emotional disorders; The state of emotional stress; Emotional lability; Emotional tension; Emotional instability; Emotional instability; Mood disturbance; Mood disorders; Decreased mood; Deterioration of mood; Mood swings

F91 Behavioral disorders: Juvenile and other behavioral disorders; Destructive behavior; Violation of behavior; Behavioral disorders; Mixed behavioral disorders; Behavioral Disorder; Behavioral disorder in adolescents with 15 years of age and adults; Violations in behavior; Behavioral disorders in childhood; Behavioral disorders in old age; Behavioral disorders in children; Behavior Disorder; Behavioral disorders in children

F98.0 Enuresis of inorganic nature: Urinary incontinence; Incontinence of non-hormonal etiology; Incontinence of inorganic etiology; Functional enuresis in children; Children's enuresis

R52.2 Other permanent pain: Pain syndrome of non-rheumatic origin; Pain syndrome with vertebrogenic lesions; Pain syndrome with neuralgia; Pain syndrome with burns; Pain syndrome is mild or moderate; Perioperative pain; Moderate and severe pain; Moderately or mildly expressed pain syndrome; Moderate and severe pain syndrome; Ear pain with otitis; Neuropathic pain

Composition and release form

1 tablet, film-coated, contains amitriptyline hydrochloride 25 mg; in a plastic bottle 50 pcs., in a cardboard bundle 1 bottle.

Pharmachologic effect

Mode of action - antidepressive, anxiolytic.

Indications Amitriptyline-Ferein

Manic-depressive psychosis (depressive phase), depression (including in childhood), mixed emotional disorders and behavioral disorders, children's enuresis (except for bladder-induced bladder hypotension), psychogenic anorexia, chronic pain syndrome.


Hypersensitivity, recently transferred myocardial infarction, anxiety-paranoid syndrome (the possibility of suicide), angle-closure glaucoma, paralytic ileus, epilepsy, pyloric stenosis, prostatic hypertrophy, ischemic heart disease with tachycardia, uncontrolled hypertension, peptic ulcer and duodenal ulcer, breast-feeding, children under 7 years.

Application in pregnancy and lactation

In the first trimester of pregnancy with caution.

Side effects

From the nervous system and sensory organs: drowsiness, disorientation, agitation, psychosis, (usually with the appointment of large doses to elderly patients); tremor of hands; sometimes - fatigue, dizziness, paresis of accommodation, tremors, extrapyramidal disorders.

From the cardiovascular system and blood (hematopoiesis, hemostasis): sometimes - tachycardia, orthostatic hypotension, cardiotoxic action, hematopoiesis.

Other: dry and sour bitter taste in the mouth, dry nasal mucosa, sometimes - urine retention, decreased potency and libido, gynecomastia, galactorrhea, increased sweating, skin allergic reactions, rarely - a violation of liver function.


Strengthens (synergism) the effect of other antidepressants. Weaken the hypotensive and anticonvulsant activity of other drugs, strengthens - anticholinergic (paralytic intestinal obstruction is possible). Inductors of microsomal oxidation - increase, cimetidine - reduces metabolism. Strengthens the effect of alcohol, barbiturates and other drugs that depress the central nervous system. Disulfiram can provoke delirium, anticholinergics or neuroleptics - hyperpyrexia (especially in hot weather).

Dosing and Administration

Inside, 25-50 mg per night, then increase the dose for 5-6 days to 150-200 mg / day (the main part of the dose - at night), if necessary - up to 300 mg / day. After the disappearance of symptoms of depression, the dose is reduced to 50-100 mg / day and continues treatment for at least 3 months. In the elderly with mild disorders, 50-100 mg / day at night. When enuresis in children younger than 6 years - 10 mg at night, from 6 to 10 years - 10-20 mg / day, from 11 to 16 years - 25-50 mg / day for no more than 6-8 months.


Symptoms: spasms (possible only after 3-5 days), expansion of the QRS complex on the ECG.

Precautionary measures

Incompatible with MAO inhibitors (the appointment is possible not earlier than 14 days after their cancellation). With caution appoint with CHD, incl. angina pectoris, arrhythmia, heart failure. During treatment should be excluded from drinking alcohol.

Storage conditions of the drug Amitriptyline-Ferein

In dry, the dark place at a temperature of 15-30 C.

Keep out of the reach of children.

Shelf life of the drug Amitriptyline-Ferein

5 years.

Do not use after the expiry date printed on the package.

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