Instruction for use: Acetylsalicylic acid + Caffeine (Acidum acetylsalicylicum+Coffeinum)

Pharmacological groups

NSAIDs - Salicylic acid derivatives in combinations

Nosological classification (ICD-10)

K08.8.0 * Painful toothache

Dentinal pain, Dentinal pains, Pain pulpitis, Anesthesia in dentistry, Pain syndromes in dental practice, Pain after removal of tartar, Pain when extracting a tooth, Toothache, Pain after dental interventions

M25.5 Pain in the joint

Arthralgia, Pain syndrome in musculo-articular diseases, Pain syndrome in osteoarthritis, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the joints, Soreness of the joints, Soreness of joints in severe physical exertion, Painful inflammatory joint damage, Painful conditions of the musculoskeletal system, Painful joint conditions, Painful traumatic affection of joints, Pain in the musculoskeletal system, Pain in Shoulder Joints, Pain in the joints, Joint pain, Joint pain with injuries, Musculoskeletal pain, Pain with osteoarthritis, Pain in the pathology of the joints, Pain in rheumatoid arthritis, Pain in chronic degenerative bone diseases, Pain in chronic degenerative joint diseases, Bone-joint pain, Joint pain, Arthritic pain of rheumatic origin, Articular pain syndrome, Joint pain, Rheumatic pain, Rheumatic pains

M79.1 Myalgia

Myofascial pain syndromes ,Pain syndrome in musculo-articular diseases, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the muscles, Tenderness of muscles, Muscular soreness in severe physical exertion, Painful conditions of the musculoskeletal system, Pain in the musculoskeletal system, Pain in the muscles, Pain at rest, Muscle aches, Muscle pain, Musculoskeletal pain, Myalgia, Muscle pain, Muscle pain at rest, Muscle pain, Muscular pain of non-rheumatic origin, Muscle pain of rheumatic origin, Acute muscle pain, Rheumatic pain, Rheumatic pains, Myofascial syndrome, Fibromyalgia

M79.2 Neurology and neuritis, unspecified

Pain syndrome with neuralgia, Brachialgia, Occipital and intercostal neuralgia, Neuralgia, Neuralgic pain, Neuralgia, Neuralgia of intercostal nerves,Neuralgia of the posterior tibial nerve, Neuritis, Neuritis traumatic, Neuritis, Neurological Pain Syndromes, Neurological contractures with spasms, Acute neuritis, Peripheral neuritis,Post-traumatic neuralgia,Severe pain of a neurogenic nature, Chronic neuritis, Essential neuralgia

N94.6 Dysmenorrhea Unspecified

Pain during menstruation, Functional disorders of the menstrual cycle, Menstrual cramps, Emmeniopathy, Pain during menstruation, Painful menstrual irregularities, algomenorrhea, algomenoreya, Pain smooth muscle spasm, Pain spasm of smooth muscles (renal and biliary colic, intestinal spasms, dysmenorrhea), Pain spasm of smooth muscles of internal organs (kidney and biliary colic, intestinal spasms, dysmenorrhea), Disalgomenoreya, dysmenorrhea, Dysmenorrhea (essential) (Exfoliative), menstrual disorder, menstruation painful, metrorrhagia, Violation of the menstrual cycle, Menstrual irregularities, Prolaktinzavisimoe menstrual disorders, Prolaktinzavisimoe menstrual dysfunction, Pain spasm of smooth muscles of internal organs, Spasmodic dysmenorrhea, Primary disalgomenoreya

R50.9 Fever unstable

Symptoms of fever, Increased body temperature, Unexplained feverish conditions

R51 Headache

Pain in the head, Cephalgia, Pain with sinusitis, Pain in the back of the head, Painful headache, Headache of vasomotor genesis, Headache of vasomotor origin, Headache with vasomotor disorders, Headache, Neurological headache, Serial headache

Pharmacotherapy

Combined drug, the effect of which is due to its constituent components. ASA has anti-inflammatory, antipyretic and analgesic effect, inhibits platelet aggregation. Caffeine increases the reflex excitability of the spinal cord, excites the respiratory and vasomotor centers, dilates the blood vessels of skeletal muscles, brain, heart, kidneys, reduces platelet aggregation; reduces drowsiness, a feeling of fatigue, increases mental and physical performance.

Indications

Headache and toothache, myalgia, arthralgia, neuralgia, algodismenorea; febrile syndrome with "cold" diseases and ARVI (acute respiratory viral infection).

Contraindications

Hypersensitivity; erosive and ulcerative lesions of the gastrointestinal tract (gastrointestinal tract) (in the phase of exacerbation), gastrointestinal bleeding; "Aspirin" asthma; hemophilia, hemorrhagic diathesis, hypoprothrombinemia, portal hypertension; avitaminosis K; kidney failure; pregnancy (I and III trimesters), lactation period; deficiency of glucose-6-phosphate dehydrogenase, children's age (under 15 years - the risk of developing Reye syndrome in children with hyperthermia in the background of viral diseases).

Carefully

Gout, liver disease.

Dosing

Inside, after eating 1-2 tablets 3-4 times a day. The maximum dose is 10 tablets per day.

Side effect

Gastralgia, nausea, vomiting, allergic reactions, thrombocytopenia, insomnia, tachycardia, increased blood pressure (arterial pressure). With long-term use - erosive-ulcerative lesions of the gastrointestinal tract, bleeding from the gastrointestinal tract; hepatic and / or renal insufficiency; in predisposed patients - bronchospasm; dizziness, headache, visual impairment, tinnitus, reduced platelet aggregation, hypocoagulation, bleeding.

Overdose

Symptoms (caused by ASA): with light intoxication - nausea, vomiting, gastralgia, dizziness, ringing in the ears. After a severe overdose - inhibition, drowsiness, collapse, convulsions, shortness of breath, anuria, bleeding. Initially, central hyperventilation of the lungs leads to respiratory alkalosis (dyspnea, choking, cyanosis, sweating). As the intoxication intensifies, the progressive paralysis of respiration and the dissociation of oxidative phosphorylation cause respiratory acidosis.

Treatment: continuous monitoring of CBS and electrolyte balance; depending on the state of metabolism - the introduction of sodium bicarbonate, sodium citrate or sodium lactate. Increased reserve alkalinity increases the excretion of ASA due to alkalinization of urine.

Interaction

Strengthens the action of heparin, oral anticoagulants, reserpine, steroid hormones and hypoglycemic drugs. Simultaneous administration with other NSAIDs (non-steroidal anti-inflammatory drugs), methotrexate increases the risk of side effects. Reduces the effectiveness of spironolactone, furosemide, antihypertensive and anti-arthritis drugs that promote the excretion of uric acid.

Special instructions

Children should not be prescribed drugs (medicinal products) containing ASA, because in the case of a viral infection, they can increase the risk of developing Reye's syndrome. Symptoms of Reye's syndrome include prolonged vomiting, acute encephalopathy, and enlargement of the liver.

With continued use of the drug, control of peripheral blood and the functional state of the liver is necessary.

Because ASA slows blood clotting, the patient, if he is to undergo surgery, must warn the doctor in advance about taking the drug.

Patients with hypersensitivity or with asthmatic reactions to salicylates or their derivatives ASA can be prescribed only with special precautions (in emergency services).

ASA in low doses reduces the excretion of uric acid. In patients with a corresponding predisposition, this can in some cases provoke a gout attack.

During treatment should be abandoned the use of ethanol (increased risk of gastrointestinal bleeding).

ASA has a teratogenic effect; when applied in the first trimester leads to a developmental defect - splitting of the upper palate; in the third trimester - to inhibition of labor (inhibition of Pg synthesis), closure of the arterial duct in the fetus, which causes hyperplasia of the pulmonary vessels and hypertension in the vessels of the small circle of blood circulation. Isolated with breast milk, which increases the risk of bleeding in the child due to impaired platelet function.