Tetrazepam - Active Substances. Instruction and Application, Dosage

Name: Tetrazepam

The Latin name of the substance Tetrazepam

Tetrazepamum (genus Tetrazepami)

Chemical name: 7-Chloro-5- (1-cyclohexen-1-yl) -1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one

Formula - C16H17ClN2O

Therapeutic substances Tetrazepam - Drugs affecting neuromuscular transmission, anxiolytics

The nosological classification (ICD-10)

G24.3 Spasmodic torticollis
G54.1 Disorders of lumbosacral plexus
M15-M19 Arthrosis
M45 Ankylosing spondylitis
M54.3 Sciatica
M54.5 Pain in the lower back
M60 Myositis
M62.4 Contracture of muscle
M65 Synovitis and tenosynovitis
M77.0 Medial epicondylitis
M77.1 Lateral epicondylitis
R25.2 Cramp and spasm

CAS code - 10379-14-3

Pharmacology

Mode of action - muscle relaxant, central.

Stimulates the benzodiazepine receptors, it increases the GABA-receptor sensitivity to the mediator and enhances the inhibitory effect of GABA in the CNS. Decreases anxiety subcortical brain structures (anticonvulsant activity), inhibits polisinapticheskie spinal reflexes. It reduces emotional stress, reduces anxiety, fear, anxiety (anxiolytic and sedative effect).

It passes through tissue barriers, including GEB. T1 / 2 - 14-16 h.

Application of the substance Tetrazepam

Muscle contractures, neurological contracture with spasms, torticollis, myositis, accompanied by severe pain, back pain and lower back, pain in tendon diseases (epicondylitis, tendonitis) and joints for kinesis-hydrotherapy.

Pregnancy and breast-feeding

Contraindicated during pregnancy (especially in I trimester). At the time of treatment should stop breastfeeding.

Side effects of Tetrazepam substance 

Drowsiness, dizziness, euphoria, paradoxical reactions (irritability, aggressiveness), muscle weakness, ataxia, skin rash, itching; when abrupt cancellation: irritability, anxiety, myalgia, tremor, insomnia, nightmares, nausea, vomiting, convulsions, decreased reaction rate, a feeling of fatigue.

Interaction

(Mutually) effects of muscle relaxants, antipsychotics, tranquilizers, tricyclic antidepressants, alcohol, sedatives and hypnotics.

Dosing and Administration of Tetrazepam

Inside, in a hospital in an initial dose of 50 mg at night; gradually increase the dose of 25-50 mg, distributing it into several times, until the effective therapeutic dose of 150 mg in 3 divided doses; if necessary - 300-400 mg / day. When outpatient treatment starting dose is 25 mg in the evening, gradually increase the dose to 25 mg, distributing it into several stages; effective dose - 75-100 mg / day. Babies - 4 mg / kg / day in divided doses. Elderly patients - half the dose. Cancel the drug should be gradual. Kinesis hydrotherapy - 50 mg for 1 hour before the session.

Special instructions for Tetrazepam

Should not be used during the drivers of vehicles and people skills relate to the high concentration of attention. At the time of treatment should refrain from drinking alcohol.

Trading names of drugs with Tetrazepam working substance

Trade Name Index

Myolastan