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Dexatobropt eye drops - is a combined preparation has antibacterial and anti-inflammatory properties. Applied topically in ophthalmology.
Tobramycin a broad-spectrum antibiotic of the aminoglycoside. Active against gram-positive and gram-negative microorganisms: Staphylococcus spp. (including Staphylococcus aureus, Staphylococcus epidermidis, including strains resistant to penicillin); Streptococcus spp. (incl. some beta-hemolytic species, some newemailusecase species and some strains of Streptococcus pneumoniae), Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most Proteus vulgaris species, Haemophilus influenzae, Haemophilus aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus (Herellea vaginacola) and some types of Neisseria spp.
Dexamethasone corticosteroids. Has a pronounced anti-inflammatory, antiallergic and desensitizing effect. Dexamethasone actively suppresses inflammation, inhibiting the release of eosinophils mediators of inflammation, migration of fat cells and reducing capillary permeability. Has no mineralocorticoid activity.
After topical application of tobramycin is absorbed through the cornea and the conjunctiva. A very small amount reaches the aqueous humor. Tobramycin reaches the systemic blood flow in very low concentrations. The local application, systemic absorption of dexamethasone - low. After instillation in the eye, penetrates well into the corneal epithelium and the conjunctiva, watery eyes moisture. The maximum activity is achieved within 10-20 min after drug administration.
Distribution of the drug observed in plasma, bile, liver, kidney, and renal excretion after 30 min from the time of admission.
Dexatobropt intended only for local use (not applicable for injection).
When using drugs containing corticosteroids, more than 10 days should regularly measure the intraocular pressure.
In the appointment of Dexatobropt simultaneously with antibiotics of the aminoglycoside for systemic use, it is necessary to monitor the concentration of tobramycin in serum, which must not exceed 8 µg/ml.
In developing allergic reactions the drug should be discontinued.
Because eye drops contain benzalkonium chloride as a preservative, it can cause irritation, and it is known that the preservative can discolor soft contact lenses. Thus, before application of the drug Dexatobropt patients should remove contact lenses and needs to be informed that you must wait 15 minutes after installation of the drug Dexatobropt before inserting contact lenses.
Use in Pediatrics
Currently, the safety and efficacy of the drug in children have not been established.
Effects on ability to drive vehicles and management mechanisms
About the adverse effects of the drug on the ability to drive vehicles and other activities that require concentration and speed of psychomotor reactions have not been reported. However, given that the patient after application temporarily lose the clarity of vision, it is not recommended to drive vehicles or operate machinery immediately after instillation of the drug.
Buried by 1-2 drops in kongungualny bag the affected eye (or eyes) every 4-6 h
After cataract surgery the dose can be increased to 1-2 drops every 2 h for 24 h. the Frequency of use of the drug should be gradually reduced with the improvement of clinical signs.
In patients older dose reduction is not required.
Before use, the vial should be shaken.
The bottle must be closed after each use. Do not touch the tip of the pipette to the eye to maintain the sterility of the solution.
Local allergic reactions: swelling, itching of the eyelids, hyperemia of the conjunctiva.
On the part of the organ of vision: increased intraocular pressure (with prolonged use). With regular use, for more than 3 months may develop fungal infections of the cornea. May slow regeneration processes, development of back subcapsular cataract, secondary infection.
Systemic reactions: headache, increased blood pressure.
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