Norepinephrine – Hormone of Predators

The promised issues of specific neurotransmitters. Now we will more fully dismantle all representatives. On this beautiful summer day, I want to start with something energetic and strong. With a neurotransmitter that can disperse the heart of a 2, 3 times faster, even without serious physical activity, and the brain would digest hundreds of options, what to do next, and the feel is quite strange but pleasant feeling of control of their lives. Norepinephrine - a favorite neurotransmitter risky and extreme people.

Norepinephrine is often confused with adrenaline, and for good reason! They are very similar, and there is still no exact answer, what is different on the effects of norepinephrine and epinephrine.

The prefix "nor" suggests that norepinephrine - that's the substance of which creates adrenaline. It is believed that in the development of norepinephrine, a man alone, for the thrill of driving himself in an extreme situation, when adrenaline is going on internally. But this is only a guess.

For what noradrenaline produces?

Norepinephrine is responsible for the fastest possible adaptation of the body to stress, it prepares the body and mind to something heavy. When norepinephrine is too much, some people can not stand the feeling of anxious waiting, begin to rage, fall into a stupor, even if this were to conditionally agree how to ride on the terrible attraction. Others, on the contrary, enchanting feel like boiling blood, laugh, feel the power in each muscle.

When norepinephrine is not too much, but not enough, it is the average adaptation of the organism, ie the good energy, alertness, elevated mood.

Where and how is produced by noradrenaline

• 1.Phenylalanyl. This amino acid is present in the food. At 100 grams of meat contains 1-2 grams phenylalanyl.
• 2.There is a similar additive. From phenylalanyl by the enzyme phenylalanine hydroxylase tyrosine created. Also there is present as an additive in food.
• 3.Tyrosine is divided into several further substances by various reactions, one of the substances - is Dopa.
• 4. DOPA enters the bloodstream and blood circulation in the brain, which acts as a consumable material to create dopamine.
• 5.Dopamine in the hydroxylation reaction, under the influence of vitamin C, it becomes finally noradrenaline!

This is the basic version of the formation of norepinephrine, but have the body, and a fallback - production by the adrenal glands. When the hypothalamus (part of the brain) begins to secrete corticotropin in the blood, and he, in turn, reaches the kidneys and starts the production of norepinephrine and epinephrine.

The important place occupied in norepinephrine adrenergic receptors. These are receptors on the surface of nerve cells that interact with adrenaline and noradrenaline. Adrenoceptors are divided into different types and have different effects in the future.

Emit alpha and beta adrenergic receptors: alpha divided into two types, on the beta 3. 5. Total Norepinephrine acts on the alpha 1 and beta 1 receptors.

What do these receptors do?

Alpha-1 adrenoceptor. Activation Effects:

• 1.Narrowing the skin vessels, as a result, increased blood pressure. Pale skin.
• 2.Dilated pupils.
• 3. Compression of the gastrointestinal tract. Suppression of appetite.

Beta-1 Adrenoceptors. Activation Effects:

• 1.Increased salivation, changes in heartbeat, namely, increased cardiac output, accelerated heart rate that requires more oxygen consumption. As a consequence, the person often begins to breathe.
• 2.Lipolysis in adipose tissue. It accelerates fat burning.

It should be understood that the more norepinephrine - the greater the effects. It is also produced by other neurotransmitters. Therefore, the same effect can be felt different from each other in different people: some will scream that "the sea is finally the big wave - let's go swimming," others that "there are big waves - are sitting at home, it is dangerous."

Pros of norepinephrine (if conditionally "not overvalued" level):

+Team throughout the body to improve the tone. The body as if preparing for something, anticipating.

+ There is a growing utilization of glucose and its transport to the muscles. Simply put: there are more energy and strength.

+ Improves oxygen exchange. The brain works faster.

+ Norepinephrine - a neurotransmitter and hormone predators. It was he who dominates the adrenaline of lions and tigers.

Cons of noradrenaline:

• "Blears' brain. That feeling when the thought flashed, but spontaneous and reckless. This is due to vasoconstriction.
• Labored breathing. - Anxiety / stress
• Blurred vision / tinnitus. The load, which increases noradrenaline in vivo:
• viewing of horror in good company)
• Extreme (rock climbing, martial arts ...)
• actions that cause fear, but committed, consciously and intentionally. If you are afraid of heights, for example, and you make up your mind to go to the roof of a tall building and look down, will be produced norepinephrine. If you tied up and planted at the edge of the roof - the adrenaline. This is the main difference.

Supplement that increase norepinephrine (some of them are very dangerous)

- Narcotic stimulants (cocaine, amphetamine, ephedrine)

- Atomoxetine

- tetryzoline

- Phenotropil/Phenylpiracetam

- Adrafilin / modafinil

- Phenylethylamine (PEA)

- DMAA

- Yohimbine

- Vitamin the B6 (indirect action - converts dofu in dopamine and norepinephrine)

- Anabolic steroids

Supplement that reduce norepinephrine: Almost all sedatives.

Outcome:

• Norepinephrine - a kind of neurotransmitter and hormone. The sense of increased production of norepinephrine is common to many predators.
• The substance of hunters / extreme / gamblers.
• Norepinephrine produced a greater degree of dopamine from a lesser - Kidneys. A large number of norepinephrine may be too much to increase the pressure and narrow blood vessels, the consequences - the deterioration of hearing, vision, intelligence.
• Few norepinephrine - what is called a "routine / boring life."
•  "Normal" is the amount of norepinephrine only please. As mentioned in many articles - all extremes - is evil.
• Depressed, with good intelligence, too sad. It is important to dispel and sometimes feel a predator that controls their lives and better without major stimulants.