Noopept Nootrop Supplement

THE PROBLEM

The range of conditions in which there are violations of basic cognitive functions (attention, memory, the ability to analyze the situation and decision-making, spatial orientation) is very broad. It includes cognitive deficits in stroke and chronic cerebrovascular disease, brain injury, cerebral lesions of various chronic neurodegenerative nature neuroinfections, posthypoxic encephalopathy, chronic alcoholism, mental retardation in children. The prevalence of cognitive pathology, as well as the diversity of its individual manifestations in different people dictate the need to expand the arsenal of substances, normalizes impaired cognitive function. Lack of mnemonic functions that occurs on a background of neurotrauma, stroke, senile vascular disorders and neurodegenerative nature occurs on the background of pronounced structural changes in the brain tissue. For the treatment of these conditions it is advisable to use products that combine with neuroprotective nootropic activity. However, most of neuroprotective substances currently used in medical practice (antioxidants, calcium channel antagonists), devoid of a direct positive effect on mnemonic function. Cerebral vasodilators, which are also widely used, cause the effect of "robbing" brain tissue expressed by general hemodynamic changes, which may lead to a deterioration of cognitive activity, especially in the elderly.

Noopept - innovative drug dipeptide structure, with extensive nootropic and neuroprotective properties.

Pharmacokinetics:

Absorption occurs within the gastrointestinal tract unaltered Noopept enters the systemic circulation. Noopept penetrates the blood-brain barrier and into the brain is determined in large concentrations than in the blood. Time to maximum concentration is on average 15 minutes. The half-life of plasma - 0.38 hr.

The major metabolite is Noopept cyclo-prolyl-glycine, which is identical with the endogenous cyclic dipeptide nootropic activity. The drug is partially retained in unchanged form, partially metabolized with the formation of phenylacetic acid, phenyl-acetyl-proline and cyclo-prolyl-glycine. It has a high relative bioavailability (99.7%). Renal excretion produced mainly in the form of its metabolite - phenylacetic acid.

The main effect Noopept established in clinical trials

Nootropic (improves cognitive function);

Anxiolytic (reduces anxiety and irritability);

Vegetative-tropic (including, and normalization of sleep);

ANTI-asthenic.

Nootropic Action

Mechanism:

effect on specific binding sites in the cerebral cortex

the formation of cyclo-prolyl-glycine is similar in structure to endogenous cyclic dipeptide possessing antiamnestic activity

the presence of choline positive action

increase in brain concentrations of neurotrophic factors (NGF, BDNF)

Therapeutic effect:

improves memory, operating at all phases: the initial information processing, storage and playback

It helps to restore memory and other cognitive functions, disturbed as a result of damaging effects (neurotrauma, local or global ischemia)

It facilitates learning processes, improves concentration, stimulates intellectual activity

Neuroprotection

Mechanism of Noopept supplement:

the weakening of the neurotoxic effect of glutamate

opposition to the accumulation of intracellular calcium

reduce the formation of free radicals

It possesses anti-inflammatory activity. Therapeutic effect:

increases the resistance of brain tissue to damaging influences (neurotrauma, hypoxia, electroconvulsive, toxic)

weakens the degree of damage to the neurons in the brain

Noopept EFFECTS IN THE EXPERIMENT:

Nootropic - impact on the ability to learn; Memory (acting on all phases: initial processing of information, consolidation and retrieval); facilitation of synaptic transmission at the level of the cerebral cortex

Antiamnestic neuroprotective - improving the stability of brain tissue to damaging influences

Anxiolytic - reducing feelings of anxiety, emotional tension)

Choline-positive

The antithrombotic (anticoagulant effect without having an antiplatelet action).

INDICATIONS for Noopept

Violations of memory, attention and other cognitive functions, and emotionally labile disorder (including elderly patients) when:

consequences of traumatic brain injury

commotion syndrome

cerebral vascular disease (encephalopathy different genesis)

asthenic disorders

other conditions with symptoms of decline of intellectual activity

DOSAGE AND ADMINISTRATION of Noopept

Noopept applied inside after eating. Treatment starts with the drug in a dose of 20 mg, 10 mg distributed into two doses during the day (morning and afternoon). In case of insufficient efficacy and good tolerability of the drug dose Noopept increased to 30 mg, 10 mg distributed on three stages throughout the day. Like most nootropics, it is not recommended to take Noopept later than 18 hours. The duration of a course of treatment is 1.5 - 3 months. Repeated treatment may be carried out after 1 month if necessary.

CONTRAINDICATIONS

Pregnancy, lactation. Age up to 18 years. Individual intolerance to the drug. Expressed human liver and kidneys.

INTERACTION

Not applicable Noopept interaction with alcohol, drugs and antihypertensive drugs and drugs stimulating effect.

ADVANTAGES of Noopept

Innovative nootrop of peptide structure:

- For the first time high resistance to intestinal neuropeptide preparation of enzymes and possibility of oral

- In the body forms an active metabolite that is identical to the endogenous dipeptide with nootropic activity

- Metabolized, bypassing the liver, with the formation of endogenous metabolites

- Very low effective doses (20 mg / day)

A wide range of therapeutic action: nootropic, neuroprotective, anxiolytic, vegetative stabilizing and others.

The effectiveness of piracetam Noopept exceeds that found in clinical studies in patients with vascular cognitive impairment and post-traumatic genesis

It has a more pronounced compared with piracetam, vegetative-stabilizing, anti-asthenic, anti-anxiety effects and helps normalize sleep

The favorable safety: the incidence of side effects when taking Noopept twice lower than when receiving piracetam.