Meldonium Sale - Frequently Asked Questions

Do I need a doctor's prescription to buy Mildronate at the pharmacy?

Mildronate, 250 mg N40 is a form of OTC drug Mildronate, 500 mg N60 and Mildronate, ampoules 10% 5ml N10 is a prescription drug forms.

In some cases, use Mildronate? Mildronate - a medicament for the treatment of cardiovascular diseases such as stable angina, congestive heart failure, cardiomyopathy, functional disorders of the cardiovascular system; appointed as acute and chronic ischemic disorders of cerebral blood flow, with reduced working capacity, physical and psycho-emotional overload.

Meldonium Indications for use:
In the treatment of coronary heart disease (angina, myocardial infarction), congestive heart failure and cardiomyopathy dyshormonal, as well as in the treatment of acute and chronic disorders of the brain blood supply (cerebral strokes and cerebrovascular insufficiency).
Hemophthalmus and retinal hemorrhages of different etiologies, thrombosis of the central retinal vein and its branches, retinopathy of different etiology (diabetic, hypertensive).
The reduced performance; physical stress, including the athletes.
abstinence syndrome in chronic alcoholism (in combination with specific alcoholism therapy).

Release form of the drug (packaging volume, dosage)
Mildronate produced in the form of capsules, tablets and injectable solution:

Mildronate, 250 mg N40
Mildronate, 500 mg N60
Mildronate ampoules 5 ml of 10% N10
What is the difference between the capsule and liquid form of the drug?The difference in bioavailability is meldonium and method of administration: parenteral or enteral administration route, which in turn affects the rate in effect. For parenteral routes of administration of the drug, its effect is faster and increases the bioavailability of the drug.

Based on what the clinical effect of the drug?
In humans, carnitine is synthesized from γ-butyrobetaine. Meldonium is a structural analogue of the gamma-butyrobetaine, and therefore can inhibit the enzyme gamma-butirobetaingidroksilaze responsible for the synthesis of carnitine. As a consequence, in the body decreases carnitine concentration and slows the process of transferring long chain fatty acids across mitochondrial membranes of heart cells (Carnitine acts in this process as a carrier of long-chain fatty acids). This slowdown is very important during the oxygen deficiency, since the normal fatty acids entering into the heart and there is insufficient oxygen partial oxidation of long chain fatty acids. Thus accumulate intermediates which have a deleterious effect on the heart tissue, for example, acylcarnitine blocking delivery of ATP to cell organelles.
Simultaneously, deceleration metabolic rate increasing carbohydrate metabolism of long chain fatty acids (glycolysis) in which there is a more effective formation of ATP in the conditions of oxygen deficiency.

This is important in the treatment of pathologies associated with myocardial ischemia (angina pectoris, heart failure), because in these cases, the heart does not receive sufficient oxygen and nutrients.