Meldonium - Active Substances

Name: Meldonium

The Latin name of the substance meldonium

Meldonium (genus. Meldonii). You can buy online Meldonium.

chemical name 3- (2,2,2-trimethylhydrazinium) propionate (monohydrate)

Formula - C6H14N2O2

Therapeutic agents of Alprazolam: Other Metabolics

The nosological classification (ICD-10)E63 Physical and mental overload
F10.3 abstinence
G46 Vascular syndromes of brain in cerebrovascular diseases
H34.8 Other retinal vascular occlusions
H35.0 Background retinopathy and retinal vascular changes
H35.6 Retinal hemorrhage
H36.0 Diabetic retinopathy (E10-E14 + with common fourth character .3)
H44.8 Other disorders of eyeball
I20 Angina [angina]
I21 Acute myocardial infarction
I25 Chronic ischemic heart disease
I50.0 Congestive heart failure
I64 Stroke, not specified as hemorrhage or infarction
R07.2 Pain in the heart
Z54.0 recovery period after surgery
Z73.6 Limitation of activities due to a decrease in disability

Characteristics of matter Meldonium

The white crystalline powder with a weak smell. Easily soluble in water, it is difficult - in alcohol. Hygroscopic.

Pharmacology

Mode of action - metabolic, cardioprotective, anti-anginal, anti-hypoxic, adaptogenic, improves cerebral blood flow.

Is structural synthetic analogue of gamma-butyrobetaine - carnitine precursor. It inhibits the enzyme gamma-butyryl-beta-hydroxylase, reduces the synthesis of carnitine and transportation of long chain fatty acids across cell membranes and prevents the accumulation of cells in the activated forms of non-oxidized fatty acids (including acylcarnitine blocking delivery of ATP to cell organelles). Improves metabolic processes. When ischemia prevents violation of transport and ATP activates glycolysis. As a result of reducing the synthesis of carnitine increases the concentrations of gamma-butyrobetaine, has vasodilating action. In acute myocardial infarction slows tissue necrosis, shorten the rehabilitation period. Against the background of heart failure improves myocardial contractility, increases exercise tolerance. In acute and chronic disorders of cerebral circulation promotes redistribution of blood flow in ischemic areas, thus improving the blood circulation to the ischemic focus. Increases cellular and humoral immunity. It eliminates the abstinence syndrome in chronic alcoholism. It increases efficiency, reduces the symptoms of mental and physical stress, enhances stamina.

If ingestion is well absorbed from the gastrointestinal tract. Bioavailability - about 78%. Cmax is achieved in 1-2 hours. The bio-transformed in the body into two major metabolites which the kidneys. T1 / 2 - 3.6 hours.

Application of the substance meldonium

The reduced performance; physical stress, including in athletes; postoperative period to accelerate rehabilitation. In the combined therapy - ischemic heart disease (angina, myocardial infarction), congestive heart failure, in the background cardialgia dyshormonal dystrophy infarction, acute and chronic cerebrovascular accidents (stroke, cerebrovascular insufficiency). Withdrawal syndrome in chronic alcoholism (in conjunction with a particular therapy). In ophthalmology - hemophthalmus and retinal hemorrhages of different etiologies, thrombosis of the central retinal vein and its branches, retinopathy of different etiology (diabetic, hypertensive) - only for parabulbarno administration.

Contraindications

Hypersensitivity, increased intracranial pressure (in violation of the venous outflow, intracranial tumors).

Restrictions to application

Pregnancy, lactation, children under 18 (capsule, injectable solution) or 12 years (syrup), since safety and efficacy have not been determined.

Pregnancy and breast-feeding

Not recommended during pregnancy (safety have not been proven). At the time of treatment should stop breastfeeding (known whether the breast milk gets).

Side effects of Meldonium substance
Dyspepsia, agitation, tachycardia, hypotension, pruritus.

Interaction
Care must be taken in combination with nitroglycerin, nifedipine, alpha-blockers and other antihypertensive agents and peripheral vasodilators. Compatible with antianginal drugs, anticoagulants and antiplatelet agents, antiarrhythmic agents, bronchodilators, diuretics.

Dosing and Administration of Meldonium Substances
Inside, in / in and / m, parabulbarno. The route of administration, dose and duration of treatment is determined individually depending on the indication, the severity of the state, etc. The average dose for adults:. Ingestion - 250 mg 2-4 times a day, parenterally - 500 mg / day, parabulbarno - 50 mg / day.

Athletes appoint special schemes in combination with other agents.

Precautions for meldonium substance

Care must be taken long-term use in patients with liver disease and / or kidney.

Trading names of drugs with working substance Meldonnium
Trade Name

3- (2,2,2-trimethylhydrazinium) propionate dihydrate
Angiokardil
Vazomag
Idrinol
Kardionat
Medatern
meldonium
Meldonium Organics
Meldonium-Binergiya
Meldonium-Eskom
Meldonium dihydrate
Melfor
Midolat
Mildronate