Melanotan 2

Melanotan 2 (Melanotan II) - peptide, a synthetic analog of a natural melanokortin (peptide which stimulates synthesis of melanin and determines suntan of skin), has properties of aphrodisiac that is confirmed by researches.

So far there is no medicine approved for application in public only laboratory substances for performing clinical trials are used, despite it Melanotan 2 actively extends on network that creates high risk of counterfeit products.

History

Melanotan 2 was for the first time synthesized at university of Arizona as an agent for protection against a carcinoma cutaneum (as the pigment a melanin performs protective function, without passing ultraviolet rays). Scientists found out that natural melanokortin the short half-life period therefore it can't be applied as drug therefore it was decided to modify its formula, for rising of fastness of a molecule has. After synthesis and screening of the large number of substances which is carried out by Victor J. Hruby and Mac E. Hadley, was found a peptide [Nle4, D-Phe7]-α-MSH which was about 1000 times more powerful, than natural melanokortin. Later he received the name melanotan 2 and was patented.

Melanotan-1 (or afamelanotide) is completely similar peptide, passed 3 phases of clinical trials, it is approved for use in public under the Scenesse trademark.

Researches in public

The first phase of clinical tests was carried out on three men to College of Medicine, Pharmacology Department, University of Arizona in Tucson, results are published in 1996. It was reported: "Melanotan 2 causes suntan in people after 5 small doses of subcutaneous injections". Among side effects it was reported: slight nausea, yawning, spontaneous erection.

Later (1998) the research on 10 men who had erectile dysfunction was conducted. Scientists concluded that melanotan 2 in a dose of 0.025 mg/kg eliminates dysfunction even if it has psychogenic character. One more research of 2000 came to the same conclusion.

Effects

• Causes a xanthopathy due to formation of a melanin (pharmacological suntan)
• Raises a libido and strengthens an erection (in 2 hours after the first injection)
• Suppresses appetite
• Promotes combustion of fat

Course

The single daily dose of a melanotan 2 makes 500-1000 mkg before achievement of a necessary shade of suntan (15-20 days). The first injection it is better to carry out with a low dose 100-200 mkg for assessment of an individual acceptability. Exact calculation on kilogram of body weight isn't obligatory as doses widely vary. Results are shown gradually within 1-3 weeks. For acceleration of a pigmentation it is possible to visit a sunbed or to sunbathe in the sun. The peptide is entered subcutaneously by the insulinic syringe, dissolved in water for injections.

Storage and preparation of solution

It is necessary to cool a vial to room temperature and to enter the required water volume for injections (which has to flow down on a vial wall), then to stir the rotating movements (not to shake). The prepared solution can be stored for 14-20 days in a refrigeration.

Schemes of application

Scheme "without melanotanovykh of freckles". Don't apply Melanotan 2 in huge dosages and with fanatical constancy; in the first week don't abuse ultraviolet and don't forget about moistening of skin. 100-200 mkg every day or in 1-2 days for 7-10 days will be quite normal dosages for people with white skin color. At this time it is possible to dare to sunbathe few times 30 minutes. For achievement of a desirable shade of skin and minimization of probability of emergence "the melanotanovykh of freckles", don't exceed dosages and you aren't long in the sun. Give the chance to your organism independently to save up melanin. MT2 in this process has to carry out only a role of peculiar "springboard" which will allow to prevent emergence of burns.

The scheme "the fastest suntan + freckles" (it is the scheme "accumulation and maintenance"). It is the most classical, untwisted by all peptide sellers, the scheme of application of MT2. It is in that for the first few days strong to increase concentration of melanin and then to maintain this concentration throughout the entire period of application of Melanotan. It looks so: since first day of application, MT2 it is necessary to put from 25% of a dosage of "norm", and each next day to increase 25%. By fourth day you will come for application of 100% of a dosage of "norm", and before achievement of the necessary shade of suntan every day it is necessary to put these 100%. To what "norm" it is necessary to become attached, unfortunately, difficult to tell. Sellers recommend to make a start from skin phototype, however there are several classifications of phototypes of skin (the fullest and clear – classification by Fitzpatrick), and the offered phototypes don't consider probability of emergence "the melanotanovykh of freckles". Application of MT2 according to this scheme, of course, will help you to sunbathe, but to become spotty as a jaguar, it is possible too. One of the Best drug is Meldonium.

And at last, it is very important to note what any of the chosen schemes won't save you from a solar burn if you abuse solar bathtubs from the first days of application of MT2. Of course, it not absolutely matches a preamble to this article, however I think, you perfectly understand that, even applying such stimulator as MT2, it is necessary to sunbathe slowly, since short sessions of stay under ultra-violet radiation. Otherwise the burn with all that it implies is guaranteed to you.

Side effects

The peptide isn't approved by FDA for use in public. Known following side effects of a melanotan 2:

• Erubescence
• Nausea
• Fever
• Dark stains on a skin which can be enlarged in sizes (has reversible character).
• Theoretically, the lesion of immune system and a complication on cardiovascular system However in researches was taped that stimulation of melanocytes doesn't lead to an ozlakochestvleniye.
• Long erection

The 3rd phase of clinical tests of a melanotan 1 is complete, it is approved for use of European Medicines Agency (EMA) Name Review Group (NRG)  that is essential confirmation of safety.

Overdose

The overdose case, namely introduction of 6 mg once is recorded. After a while after an injection there was expressed pain which has extended to all body. Doctors have found considerable increase of a warm rhythm and increase in arterial pressure; the analysis of urine has shown significant increase in allocation of a myoglobin – the protein which is the indicator of injury of muscles. The high dose of a melanotan 2 has caused destruction of muscle fibers that has led to increase in protein content in plasma, and as a result, to injury of kidneys.

Further researches have shown that melanotan 2 can be potentially dangerous to muscles (and an organism in general) in dosages, higher, than 6 mg a day. Anyway it isn't recommended to exceed a daily dosage in 1 mg and if you feel violation of work of heart or pain in all body, reception of medicine needs to be stopped immediately.