Luteolin

Luteolin is the flavonoid found in rosemary, thyme, parsley and a citrus is effective anti-estrogen about what witness the researches on animals published by researchers from "Peking University Health Science Center" in the Pharmacology and Experimental Therapeutics magazine. Unlike pharmacological anti-estrogen, luteolin also promotes improvement of balance of cholesterol.

The Chinese pharmacologists from Istitut Biologiya of the city of Chengdu researched more than 100 substances which have anti-estrogenic properties, and luteolin was the most interesting of them.

Research

The experiment was made on females of mice which removed in the surgical way ovaries. Daily did to a number of animals injections of androstendion who by means of aromatasia enzyme easily turns into an estradiol.

Some animals orally received luteolin. The equivalent of dosages for a human body varies within 45-450 mg a day. Some mice received also injections of letrozole, powerful pharmacological inhibitor of an aromatasia.

Results

Upon termination of a 12 weeks experiment researchers measured concentration of Oestradiolum in a blood of mice. The anti-estrogenic effect of luteolin was same, as well as effect of letrozole.

Researchers used in an experiment also mice about Oestradiolum sensory cancer cells of mammary glands. As it appeared, and letrozole, and luteolin are inhibitors of body height of tumors, but letrozole copes with this task a little better. Do not forget take Ovariamin for better results.

Long-term use of pharmacological inhibitors of an aromatase results in side effects, one of which is deterioration in cholesteric balance. With augmentation of concentration of lipoproteins of low density (LPNP) concentration of lipoproteins of high density (LPVN) decreases. Luteolin though is aromatasia inhibitor, but renders opposite effect on balance of cholesterin. Luteolin reduces concentration of a "bad" cholesterin and increases the level of "good". Besides, luteolin doesn't exert any impact on the level of triglycerides.

Conclusion

"Though luteolin is widespread in products of plant origin, the dosages used in this research were above the normal level which the person consumes from vegetable products", - researchers write. "Nevertheless, this research can provide a scientific basis for use of this flavan in pharmacological branch".

"Long-term reception of inhibitors of aromatasia is, as a rule, bound to disturbance of cholesteric balance. Reception of luteolin can be the potential mechanism of normalization of balance of cholesterin without prejudice to aromatasia level", - researchers consider.