List of the most effective antidepressants

A major depressive disorder today is one of the most common, problematic and costly psychiatric nosologies. Available approaches to treatment Major depressive disorder or clinical depression can be divided into two broad categories: pharmacological and non-drug.

Most often, antidepressants are used to treat a major depressive disorder. Despite the fact that the drugs of this group are used very widely, the scientific literature regularly raises controversies concerning both the effectiveness of antidepressants in general, both the group and the differences between the efficacy and tolerability of individual drugs.

The main result of the study was the conclusion that all antidepressants are more effective than placebo in treating clinical depression in adults.

The most effective antidepressants:

- agomelatine,
- amitriptyline,
- escitalopram,
- mirtazapine,
- paroxetine,
- venlafaxine
- vortioxetine.
The list of the least effective drugs is as follows: fluoxetine, fluvoxamine, reboxetine and tradozone. As for the tolerability of antidepressants, the leaders in this indicator were agomelatine, citalopram, escitalopram, fluoxetine, sertraline and vortioxetine.

The results of the updated systemic review and meta-analysis prove the effectiveness of various antidepressants. This information can be useful for patients, doctors and health care organizers.