Immunogenetics

Immunologist Dr. Doping talks about animal models, sensitivity to tuberculosis and interaction "parasite - host".

Tasks before us have always been about the same. It is necessary to determine which genes in the mouse genome to control the start of severity of the disease itself and the susceptibility to the disease. The fact that this problem is solved very slowly. Tuberculosis - a chronic infection, even a sick mouse on year. And although they can cross, to receive the desired hybrids engaged in breeding, breeding new strains of mice, it still is very slow. And by observing what a mouse suffering from tuberculosis hard, and what - is much easier to identify at least one gene in my case 15 years have passed. This, we have found and identified through and precisely one of the genes, which is involved in the control of tuberculosis infection.

The problem of drug resistance - is the center of the clinical science of tuberculosis. This is an extremely important issue. And here we are losing the battle against the microbe. We must say frankly that the microbe smarter and faster evolving. Bacteria produce great resistance to medicines. Therefore, it is important to apply the medicine the doctors did not use his one, believing that it will help with all. This is the easiest way to select the resistance to it population. Any medication should be used in combination with other drugs. And, secondly, you must finish the cure. Under no circumstances should not lose focus on the patient, simply achieving what he has ceased to be allocated bacteria.

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Tuberculosis - it's a great biological model of the interaction between parasite and host. It is the task of evolutionary biology with methods of immunology, molecular genetics. Interaction "parasite - host" - is the most complex biology that is only because one is struggling with another gene. And evolution does not favor the man on the microbe. Evolution is all the same, what the population will be more adapted. Therefore, the fundamental problem of how to interact with two of the genome to achieve results in the evolution - is not an evolutionary purpose. The goal is always the same - the total fitness of the population - and microbe and host - must be increased. But how to reach a balance point that makes this microbe that this makes the owner - the foundation and immunology, and microbiology.