Cortexin - Nootropics from the Brain of Animals
11 Apr 2018
Neuropeptide nootropic - Cortexin.
Recall that this group of neuropeptides can be attributed and Semax with Selank and Noopept and Cerebrolysin / Cerebrolysate.
This group of nootropics is often criticized for a poor evidence base, and it really is. In general, nootropics have a weak base for the treatment of some kind of intellectual disturbance. We did the issue on this subject "Hayter's Nootropics" and its essence is that the brain is extremely complicated, and there is no such tablet to work on all the memory mechanisms and improve it, as an example. In this case, no one cancels the principle of work of each nootropic.
Imagine the brain as auto, and each nootropic as an auto element. And say, if you know for sure that the wheel is punched, the nootropus X patches it, and the nootropic Y dips fuel, but the car will still be with the punctured wheel, although the nootropic Y also had a positive effect.
Neuroprotective effect
Or the effect of protecting the nerve cells. It is known that with age the number of nerve cells decreases, and although they are capable of recovery, neurogenesis, the rate of dying goes faster. Often, closer to old age, this leads to intellectual disabilities. One of the ways of such apoptosis - the death of nerve cells, is the activity of so-called caspases. Cortexin is able to inhibit or turn off certain caspases, which is best preserved by neurons.
Yes, apparently it was difficult!) More clearly, under cortexin, all that kills nerve cells - will kill less. This includes the effects of alcohol and other drugs, senile changes, and other negative effects on the brain.
Even in conditions with a lack of oxygen, cortexin is able to maintain an optimal working state, so it can help in sports.
Neurogenesis
This is the second main effect that all neuropeptides are famous for. Means the creation of new nerve cells through stimulation in the cerebral cortex of the transcription of neurotrophins (NGF, BDNF). Consider brain renewal. Which is extremely effective if there are any brain injuries. And in ordinary life, visiting new places, new activities, physical training also improve neurogenesis. In short, this is a useful effect for any person.
Anti-stress action
In at least 2 studies, there was a change in the level of cortisol, one of the main stress hormones. More precisely, if the level is too high, it decreases. Therefore, you feel less nervous.
There was another mention that Cortexin can increase serotonin. The main antidepressant neurotransmitter. There is no direct connection with stress, but there is one type of depression, this can also be attributed to stress.
Other Action
Data on the positive effects in the treatment of the effects of chronic alcoholism.
A study of neurasthenia in adolescent girls showed an improvement in 80% of cases, although without a placebo group.
A recent study in 2018 showed an excellent combination of Memantine and Cortexin and a significant improvement in intellectual function in patients with ischemia.
Effects of Cortexin
This is a more subjective point, from personal experience and feedback on the network:
- Striving for novelty
An unusual effect, manifested in a great desire to hammer the information. And do not just turn the tape, but rather read books, learn languages or programs, attend courses. It seems that the degree of interest in any case is increased by several points.
- Humanity
At first I wanted to write rationality, but this is not a crude logic. Strongly growing and emotionality, empathy. In this case, there is a similar phenibut effect of less aggression and relaxation. So emotions are not in the negative side.
- Dreams
Sometimes they even fret, it's all too realistic. And after awakening, a few more seconds are needed to return to the familiar reality.
- Reduction of animal motivation
This is both a bad and good effect, less concerned with the instinct of "Dominate, Conquer, Humiliate." Less motivation for sports and parties for the whole night, more to the intellect and to the quality of social contacts, rather than quantity.
For the sake of justice, I will immediately inform you that these effects can also be attributed to Cerebrolysin, Selank and Noopept (in descending order) so that the detective does not wake up in you and does not look for advertising for something specific.
The Cortexin course
The substance has a few contraindications and side effects, read the instructions.
It is used intramuscularly / intravenously. And yes, if you are not under the supervision of a doctor, then no intravenous infusion, this is very dangerous!
There's still a way to prepare the solution!
Usually a course or every day of 10 mg intramuscularly, or every other day. Total injections 10. In the gluteus muscle. If you decide - be sure to read how to do the injections in order to avoid getting into the vessel. Effects appear immediately, but more noticeable by the end of the course and after it.
Outcome:
- Cortexin is a neuropeptide, similar to other nootropics from the same group.
- Works as a neuroprotector, increases neurogenesis, antistress effect. At least, there are studies on these items.
- In medicine it is used for a number of diseases, mainly associated with ischemia, stroke and encephalopathy.
- Subjective effects: the desire for novelty, dreams and reduction of animal motivation.
- The course consists of injections of 10 mg per day
Well, the substance is unusual and interesting! If used - tell us what and how, confirm or deny the information!