Cerebrolysin ampoules - Instructions for Use, Dosage, Side Effects, Reviews

Synonyms: Cerebrolysinum suillus, Gehirn-Proteolysat, Derivado peptidico de cerebro de cerdo.

Active substance: Cerebrolysin concentrate (complex peptides derived from porcine brain).

ATC - N06BX Other psychostimulants and nootropics.

Pharmacological group - Nootropics.

Cerebrolysin - a peptide drug created using new biotechnological methods, providing a neurotrophic effect on central nervous system.

Cerebrolysin is used worldwide for the treatment of ischemic (in the acute and recovery period) and hemorrhagic (the recovery period), stroke, traumatic brain injury. This drug having neuroprotective and neuro-regenerative properties for the treatment of both acute and chronic neurodegenerative diseases.

Nosological classification (ICD–10)

F00 Dementia in Alzheimer’s disease (G30 +);

F01 Vascular dementia;

F03 Dementia, unspecified;

F32 Depressive episode;

F79 Mental retardation, unspecified;

F90.0 disturbance of activity and attention;

G93.4 Encephalopathy, unspecified;

I63 Cerebral infarction;

I67.9 Cerebrovascular disease, unspecified;

R46.3 Excessive of activity;

S06 intracranial injury;

S06.0 Concussion;

T14 Injury of unspecified site.

Cerebrolysin Composition, structure and packing

Solution for injection amber, water, transparent. Vials of dark glass.

Active substances 1 ml amp. 5 ml amp. 10 ml amp.

Cerebrolysin concentrate (complex peptides derived from porcine brain) 215,2 mg /1.076 g/ 2.152 g

Excipients: sodium hydroxide, water for injections

Cerebrolysin Pharmacological action

Nootropic drug.

Cerebrolysin contains low molecular weight biologically active neuropeptides, which penetrate the BBB and went directly to the nerve cells. The preparation has an organ multimodal action on the brain, i.e. provides metabolic regulation, neuroprotection, functional neuromodulation and neurotrophic activity.

Metabolic control: drug Cerebrolysin improves the efficiency of aerobic energy metabolism of the brain, improves the intracellular protein synthesis in the developing and aging brain.

Neuroprotective effect: the drug protects neurons from the damaging effect of lactic acidosis, prevents the formation of free radicals, improves re-survival and prevents neuronal death in conditions of hypoxia and ischemia, reduces the damaging neurotoxic effects of excitatory amino acids (glutamate).

Neurotrophic Activity: drug Cerebrolysin - the only peptidergic nootropic drug with proven neurotrophic activity similar to the action of natural neuronal growth factors (NGF), but manifests itself in terms of peripheral administration.

Functional Neuromodulation: the drug has a positive effect in disorders of cognitive functions, improves concentration, memory processes.

Pharmacokinetics

Cerebrolysin complex composition, the active fraction of which consists of a balanced and stable mixture of biologically active oligopeptides having total polyfunctional action does not allow for the usual pharmacokinetic analysis of individual components.

Cerebrolysin Dosage

Drug should be used parenterally. The dose and duration of administration depends on the nature and severity of the disease, as well as the patient’s age. Possibly a single administration of the drug at a dose of 50 ml, but more preferably, a course of treatment.

The recommended course of treatment is daily injection for 10–20 days.

Reading Dose

Acute conditions (ischemic stroke, traumatic brain injury, brain surgery complications) from 10 mL to 50 mL

In the residual period of stroke and traumatic brain and spinal cord 5 ml to 50 ml

Psychoorganic syndrome and depression 5 ml to 30 ml

Alzheimer’s disease, vascular dementia and Alzheimer-combined vascular origin 5 ml to 30 ml

In neuro pediatric practice 0.1–0.2 ml/kg body weight

To increase the effectiveness of treatment can be conducted up to repeated courses until an improvement in the patient’s condition due to the treatment. After the first course of the frequency of injection may be reduced to 2 or 3 times a week.

Cerebrolysin used parenterally in the form of W/O injections (to 5 mL) and the in/injection (10 ml). Drug at a dose of 10 mL to 50 mL recommended only by a slow/infusion after dilution standard solutions for infusion. The duration of infusion was 15 to 60 min.

After opening the ampoule/vial Cerebrolysin solution should be used immediately.

Cerebrolysin Overdose

Currently, the cases of drug overdose Cerebrolysin were reported.

Cerebrolysin Drug Interactions

With simultaneous application of Cerebrolysin with antidepressants or MAO inhibitors may enhance their mutual action. In such cases it is advisable to reduce the dose of the antidepressant.

Pharmaceutical interactions

Cerebrolysin is incompatible with solutions, which include lipids, and with solutions that change the pH (5.0–8.0).

Cerebrolysin at Pregnancy and lactation

Caution should be used in Cerebrolysin at I trimester of pregnancy and lactation.

Use of the drug during pregnancy and breastfeeding is only possible when the intended benefits to the mother outweighs the potential risk to the fetus/newborn.

The results of experimental studies give no reason to believe that Cerebrolysin has any teratogenic or has a toxic effect on the fetus. However, similar clinical studies have not been conducted. Cerebrolysin Side effects

Side effects are common (> 1/100, <1/10), uncommon (> 1/1000, <1/100) and in some cases (> 1/10, 000, <1/1000) and in rare cases (< 1/10, 000).

At excessively rapid introduction: rarely - a sensation of heat, sweating, dizziness, and in rare cases - tachycardia or fibrillation.

Digestive system: rarely - loss of appetite, indigestion, diarrhea, constipation, nausea and vomiting.

CNS and peripheral nervous system: rarely - excitement, exhibit aggressive behavior, confusion, insomnia, and in rare cases - grand mal seizures, convulsions.

Allergic reactions: In rare cases - hypersensitivity reactions manifesting headache, pain in the neck, legs, lower back, shortness of breath, chills and collaptoid state.

Local reactions: rarely - skin redness, itching and burning at the injection site.

According to the results of clinical studies have reported the following side effects occur:

Cardio-vascular system: in single cases - hypertension, hypotension.

CNS and peripheral nervous system: in rare cases - fatigue, tremor, depression, apathy, dizziness.

Other: in rare cases - hyperventilation, flu-like symptoms (cough, runny nose, respiratory tract infections).

Note that some unwanted effects (agitation, hypertension, hypotension, lethargy, tremors, depression, apathy, dizziness, headache, shortness of breath, diarrhea, nausea) were identified during clinical trials and occurred equally in both patients, Cere treated and placebo patients.

Cerebrolysin Indications

Alzheimer’s disease;

Syndrome of dementia of various origins;

Chronic cerebrovascular insufficiency;

Ischemic stroke;

Traumatic brain and spinal cord;

Mental retardation in children;

Hyperactivity and attention deficit disorder in children;

Endogenous depression resistant to antidepressants (as part of combination therapy).

Cerebrolysin Contraindications

Acute renal failure ;

Status epilepticus;

Cerebrolysin Cautions

At excessively rapid implementation injections can sense heat, sweating, and dizziness. Therefore, the drug should be administered slowly.

Checking and confirming the compatibility of the drug (for 24 hours at room temperature and the presence of light), with the following standard infusion solution: 0.9% sodium chloride solution, Ringer’s solution, 5% dextrose (glucose).

Simultaneous application of Cerebrolysin with vitamins and drugs that improve cardiac blood flow, however, these drugs should not be mixed in the same syringe with Cerebrolysin.

Should not be mixed in the same solution for infusion Cerebrolysin and balanced amino acid solutions.

Use only clear solution Cerebrolysin and only once.

Effects on ability to drive vehicles and management mechanisms

Clinical trials have shown that Cerebrolysin has no effect on the ability to drive vehicles and use machinery.

Cerebrolysin Reviews

Alexa, years 28, The drug " Cerebrolysin " - Cerebrolysin: relieves stress from the nervous system and helps to develop it in young children!
Advantages:
It helps both adults and children

I never thought that the usual nootropic medicine is able to help people with very different - from my perspective - diseases. My story is quite simple. Fatigue, stress, nervous stress - all lumped together and I surrendered to the mercy of a neurologist, because she knew that the nerves should be treated as long as they still have. One way of treating neurologist and prescribed me two courses of injections " Cerebrolysin ". From the word "prick" I have my opinion and more nervous tic began, because this action is afraid of more than anything else. I have even from the hospital the most terrible reminiscence - is when after giving birth to me without warning rolled a shot in the thigh: I screamed louder than battles!

But this is so, the background. The course I started to pass immediately, a nurse from the vaccination office I got smart - she never showed me nor the syringe or needle. A vial I bought at the beginning of treatment, and they were in her office.

About myself I can say that even the first course of treatment, "Cerebrolysin " significantly helped me: left headache, normalized sleep, anxiety went away. Very happy with the present state of the stand, because life was something good!

Masha, 33 years, " Cerebrolysin " - Excellent and proven preparation time

All moms want their kids to be healthy, and that I am one of them. I buzzed constantly, it is necessary to be vaccinated, but the inner stopper stops me, and it did not work in vain. To go to the reception to the neurologist, he looked up and said that her son was a lack of oxygen during labor. We have a son, a movable, such children are called spermatozoa, at first glance, do not say that he may have problems with focus on legs. He stood alone in the crib in seven months and went on a side, then there was my mistake, I put his son in a walker. Son become more than to sit down and crawl.
The neurologist prescribed drug "Cerebrolysin" in 0.5 ml of massage and ten days, and three times drink valerian. The standard package of 10 vials, but we had to throw away 0.5 ml in the trash, because the drug is not kept, and I would keep myself not to become a child not spare. Store this medication in the refrigerator is necessary if stored at room temperature, it will be gone, and pierce just waters.
We calcined the first course and did a massage, for me is not very much that it became a stop on the legs, but the therapist said, after the last massage that was a good emphasis. With the speech, before the son muttered something in its own way after the fifth injection son said to give. After the eighth injection have broken through, say mom, dad, grandmother, grandfather, though still not clear, but the first words very pleased. After the drug in combination with massage, I saw a good result.
Now, whether in thought prick second 10 pieces of 0.5 ml and drink valerian, the result is 100%. Masseur says that everything is fine with us that do not need to stabbing.
The drug is administered intramuscularly, administered slowly, my son did not cry. But how much cost me nerves as I was afraid that my little boy is going to hurt.
P.S. The drug is time-tested, with the doctor spoke, he said that the drug for about 25 years. So I recommend. In general, I wish you and your baby's health, it is better not to come in handy.