Bread of psychiatry. Aminazin (Chlorpromazine).

The history of scientific discovery is rich in incidental findings. Only the search for the philosopher's stone as the entire distance. And phlogiston also did not disappoint. Onewill seek some for some hard-to-findum - again something to be found. Roughly the same thing happened with Aminazine (chlorpromazine).

No one planned to open the world's first antipsychotic. Not that laziness was - just did not know which way to search for. The treated to chlorpromazine, I wrote. And in 1950, trying to synthesize a new powerful antihistamine, received a white crystalline powder that is darkened, rested for a while in the light. His first tested was by anesthesiologists. No, no, this powder through a straw nose is not inhaled - just tried to give during anesthesia with basic preparation, the proportion of the potentiating effect. It is, incidentally, quite well.

And in 1952, American psychiatrist Frank Ide decided to give chlorpromazine (this is its international non-proprietary name) as a sedative for the residents of psychiatric hospitals. And then all bromine, lithium barbiturates. . And so it surprised good effect that he became actively recommend to colleagues, saying that you try it! And since 1953, a new era began in psychiatry. The new era of Neuroleptics.

From that moment, as they like to express an old professor, these mentally ill people have gradually disappeared from the hospital. Why? Yes, because before the advent of chlorpromazine many of the patients have lived there for years, until his death. Especially those who, say, the same schizophrenia flowed continuously. Who will keep a man at home? Only very few of the relatives. And here is a medicine with a powerful calming effect. And some (not very strong and not very specific, but other drugs, and that something was not!) It has action on delusions and hallucinations. That is, it is possible the time to treat patients on an outpatient basis, outside the hospital. And it was a breakthrough.

Of course, the drug is not perfect, what is his thought at first. Yes, he has a lot of side effects from neuroleptic syndrome and finishing skin photosensitivity (the entire list will not disclose, it's easier to look in the directory). Yes, the site of the injection of chlorpromazine is very hurt and sometimes inflamed. Yes, it is volatile, which makes and inhalation dose resulting personnel on duty and procedural sisters - in the treatment room. But for a long time, chlorpromazine was what is called the bread of psychiatry. And now also applied quite widely. True, in supporting roles. When exactly? You can try Phenibut.

Firstly, chlorpromazine is give when the patient should reassure psychosis, symptoms muffle brightness. Soothe - in this case does not mean calm the anxiety neurotic. Neurotic would be just cut down by chlorpromazine. No, we are talking about a completely different level of agitation. About this, for example, when in the midst of psychosis, the patient stubborn, rushes, rages and can either hit someone or himself, to hurt himself.

Secondly, Aminazin is not bad in small doses when it is necessary to reassure the excessively restless, hyperactive elderly person with dementia: I wrote that tranquilizers in this case, often give a paradoxical effect, up to the delirium.

Third, chlorpromazine used in lytic mixtures. That is, those that can quickly bring down a very tall temperature of 40. Usual "Triad" is chlorpromazine-analginum-diphenhydramine (Dimedrol). Or variations of the second and third drug. Cheap and cheerful. The list of cases is far from complete, but the main I have outlined.

Later, a few years after inventing, chlorpromazine (Aminazin) served as the basis for the creation of new antipsychotics, more precisely acting on certain groups of symptoms.