Atomoxetine aka Strattera

Waited releases for something unusual, well, you get what I'm sure many have not heard. This vigorous garbage has exactly strongly and sharply on norepinephrine, like a blow needle straight into the heart. In Russia, the drug is assigned to deal with ADHD. And I must say, this is a strong drug that is far away from Ritalin or Modafinil. ADHD actually reduces its expression, even in children. Atomoxetine (Strattera) - even the name itself is a vague association with the splitting of atoms and release monstrous energy. But what is it?

It is a synthetic compound, which is sold under the "Strattera" trademark, has no analogues, or almost no, something like our "phenylpiracetam". The drug was approved by FDA in 2006 for the treatment of ADHD, the validity of the patent "Strattera" ends in 2017.

The first thing we understand, is that atomoxetine is not a stimulant in a pure form. However, the stimulating effect for a long time, because its half-life - 5 hours.

How does Atomoxetine act?

• 1. It inhibits the reuptake of norepinephrine. This is the main important action Strattera. If we recall the effects of norepinephrine, that comes to mind vasoconstriction, high blood pressure, increased performance and excitement, playfulness. Unlike stimulant drugs, it does not increase the synthesis of Atomoxetine this mediator. It only prolongs its interaction with the adrenergic receptors. Ie, there is no need to create the body of norepinephrine, dopamine, depleting its reserves, or take from the adrenal glands. Norepinephrine increased 3-fold in clinical dosages.

Hence the conclusion that atomoxetine is not a psychostimulant. However, by reacting with substances that increase the secretion of catecholamines (dopamine, norepinephrine, epinephrine) may cause the effect of drugs and psychostimulants corresponding side effects. Therefore, the main thing to be as careful and do not have nootropics everything.

• 2.It stimulates the production of dopamine. Since dopamine or dopamine, someone as comfortable, connect centers of pleasure and motivation. In terms of abuse - it's bad, because people love undeserved pleasure. On the other hand, this effect may be useful for the development of noradrenaline, dopamine because they are like brothers. In particular, atomoxetine dosage 1-3 mg / kg.
• 3.It improves cognitive abilities. Another study with mice and a maze. Troll mice and placed even in a hopeless maze and observed how quickly they will understand what's what. There were several groups of mice, one administered atomoxetine, another inhibitor of serotonin, a third - a derivative of amphetamine. Groups with atomoxetine and a stimulant were better and faster tests than happy serotonin mouse. Moreover, in the group with atomoxetine had no phenomena hyperstimulation, these predatory quiet noradrenaline mouse.
• 4.Struggling with depression. As you know, improving the use of norepinephrine by the body results in a better state of health, there is a liveliness. Usually, antidepressants focus on serotonin, and patients often complain of deterioration of intellectual abilities. In the case of atomoxetine improved memory even in a study on mice.
• 5.Improves the rate of reaction. Quite creative This effect was investigated on mice as well. Roughly speaking, they measured the speed of nerve impulses from the retina to the visual cortex in response to light stimulus and a mouse under atomoxetine think quickly, have noticed and reacted to changes in the environment. It is fair to say that this is the effect of norepinephrine rather as a whole, rather than our present matter.

Course of Stattera (Atomoxetine)
The most common side effects are: nausea, loss of appetite and insomnia. We can say, it is typical for norepinephrine-targeted drugs.
A couple of interesting side effects:
- Suicidal thoughts. In one large study reported that some children treated with atomoxetine, a great start to think about suicide than the placebo group. Or maybe it's a conspiracy) Approximately 4 people in 1000 a notice such thoughts.
- Aggressiveness. Direct communication with noradrenaline, evil predatory behavior. It occurs rarely but still happens.
Contraindications associated with cardiovascular diseases: arrhythmia, tachycardia, hypertension, etc. You can also like Bronhalamin.

Atomoxetine is used 1 time per day, an approximate dosage of 40-80 mg. No exact duration. norepinephrine reuptake inhibitors - it will not glycine if the doctor did not write, that is, it is often impossible to accurately. And the toad strangling is, if you're not a millionaire some)
Peak effects or the maximum plasma concentration observed 1-2 hours.

Compatibility with other substances
The first thoughts that arise in the amateurs himself disperse, revolve around the same idea: "Atomoxetine inhibits norepinephrine, so it is necessary to pump! So, where's my geranium ?! Where Yohimbine? Now pancake will create a time machine! ". In short, I advise you to forget this idea in excess noradrenaline behaves very unstable. You can just sleep on the vasoconstriction and hyperventilation. Though as you know, all of a sudden you get)
With the combination of tranquilizers is illogical. As for adaptogens, caffeine or stimulants glutamate light - it will more fun.

Bottom Line:

- Atomoxetine - a mild stimulant, causes the phenomena hyperstimulation or tremor in adequate doses.
- Take it at the same time, 1 time a day at a dosage of 40-80 mg.
- Side effects - there are side effects from noradrenaline: nausea, insomnia.
- Do not try to strengthen it further synthesis of noradrenaline. Adaptogens light stimulants to help.
Predatory atomoxetine dismantled!