Akatinol Memantine tablets - Instructions for Use, Dosage, Side Effects, Reviews

Synonyms: Evy, Exiba, Lemix, Mimetix, Talentum, Vivimex, Zeimer, Abixa, Akatinol memantina, Akatinol Memantine, Akatinol, Albix, Alois, Alpex Valcox, Alzant, Apo-Memantine, Axura, Carrier, Cloridrato de Memantina, CO Memantine, Cogito, Conexine, Cordure, Demantin, Demax, Dementa, Ebixa, Eutebrol, Fentina, Ilumin, Korint, Limember, Lindex, Lucidex, Manotin, Melanda, Melarth, Memantine Canon, Memantin Pliva, Memantine Teva, Memanxa, Memax, Memikare, Memorix, Memox, Merital, Mimetix, Modualz, Namenda, Namenda XR, Neuro-K, Neuroplus, PMS-Memantine, Pronervon, ratio-Memantine, Witgen, Zarlyn.

Active substance: Memantine.

Memantine reduces the actions of chemicals in the brain that may contribute to the symptoms of Alzheimer's disease.

Memantine is used to treat moderate to severe dementia of the Alzheimer's type.

ATC - Memantine N06DX01

Pharmacological group - Other means of neurotropic.

Nosological classification (ICD–10)

F00 Dementia in Alzheimer’s disease (G30 +);

F01 Vascular dementia;

F03 Dementia , unspecified;

F04 Organic amnesic syndrome, not induced by alcohol and other psychoactive substances;

G20 Parkinson’s Disease;

G21 Secondary parkinsonism;

G22 Parkinsonism in diseases classified elsewhere;

G35 Multiple Sclerosis;

G45.9 Transient cerebral ischemic attack , unspecified;

G95.9 Disease of spinal cord , unspecified;

I69 Effects of cerebrovascular diseases;

R25.2 cramps and spasms;

R41.3.0 * Reduced memory;

R53 Malaise and fatigue;

S06 intracranial injury.

Memantine Composition, structure and packing

Tablets, film-coated white, oblong, biconvex, scored on both sides.

Memantine Pharmacological action

Drug improving cerebral metabolism, used to treat dementia. Memantine is a noncompetitive NMDA-receptor antagonist, has a modulatory effect on the glutamatergic system. Regulates ion transport, blocks calcium channels normalizes membrane potential, improves the transmission of nerve impulses. The drug improves cognitive processes, increases daily activity.

Memantine Akatinol Pharmacokinetics

Absorption and distribution

After oral administration of memantine rapidly and completely absorbed from the gastrointestinal tract. C max is achieved within 2–6 hours

With normal renal function, accumulation of memantine were observed.

Breeding

Dualfaze excretion. T 1/2 is an average of the first phase of 4–9 h, in the second phase - 40–65 hours excreted in the urine.

Memantine Dosage

The drug is taken orally with meals. Mode set individually. Recommend to begin treatment with the appointment of the minimum effective dose.

Adults with dementia syndrome prescribed drug for the 1st week of treatment at a dose of 5 mg/day for 2 weeks - at a dose of 10 mg/day during the third week - 15–20 mg/day . If necessary, may further increase the weekly dose of 10 mg to achieve a daily dose of 30 mg.

The optimal dose is reached gradually by increasing the dose every week.

Memantine Akatinol Overdose

Symptoms may increase the intensity of side effects.

Treatment: gastric lavage, activated charcoal, symptomatic therapy.

Memantine Akatinol Drug Interactions

With simultaneous use of Memantine Akatinol with L-dopa preparations, agonists of dopamine , anticholinergics action of the latter may be exacerbated.

With simultaneous use of Memantine Akatinol barbiturates, neuroleptics may decrease effect of the latter.

In a joint application Akatinol Memantine may change (increase or decrease) the effect of dantrolene or Batrafen, so doses should be selected individually.

Avoid co-administration with amantadine , ketamine and dextromethorphan.

In a joint application with the drug Memantine Akatinol may increase plasma concentrations of cimetidine, procainamide, quinidine, quinine and nicotine .

When combined with memantine may reduce plasma concentrations of hydrochlorothiazide.

Memantine at Pregnancy and lactation

Akatinol Memantine is contraindicated during pregnancy and lactation ( breastfeeding ).

Memantine Side effects

Determining the incidence of side reactions often (≥ 1/10), often (≥ 1/100, <1/10), rare (≥ 1/1000, ≤ 1/100), rare (≥ 1/10, 000, ≤ 1/1000), very rare (≤ 1/10 000), the frequency is not set (the currently available data on the incidence of adverse reactions are absent).

From the body as a whole - Often Headache; Rarely Fatiguability.

On the part of the psyche -Often Drowsiness; Rarely Confusion, hallucinations

From the nervous system -Often Dizziness; Rarely Gait disturbance; Very rare Convulsions.

Cardio-vascular system - Rarely Hypertension, venous thrombosis/thromboembolism. Rarely Heart failure.

From the digestive system - Often Constipation; Rarely Nausea, vomiting.

The respiratory system - Often Dyspnea; Infections -Rarely Fungal infections .

Memantine Indications

Alzheimer’s type dementia of all severities;

Vascular dementia of all severities;

Mixed dementia of all severities.

Memantine Contraindications

Pronounced renal dysfunction;

Pregnancy;

Lactation (breastfeeding);

Age 18 years (not enough data);

Hypersensitivity to the drug.

Be wary prescribers in thyrotoxicosis, epilepsy, convulsions (including history), myocardial infarction, congestive heart failure.

Memantine Cautions

Effects on ability to drive vehicles and management mechanisms

In patients with Alzheimer’s disease at the stage of moderate or severe dementia usually compromised ability to drive vehicles and management of complex mechanisms. Furthermore, memantine may cause a change in the rate of reaction, so patients receiving outpatient treatment, should use extreme caution when driving or operating machinery.

Memantine Reviews

Ivan 43 years, With Akatinol Memantine been working for five years. In general, the drug is very happy. Do not substitute for people with cognitive impairment whose brains starts causing trouble.
Prescribe drugs to people with varying degrees of severity of dementia, frontal psyche negative manifestations, patients undergoing neuroinfections, patients with toxic encephalopathy and dismetabolic. And almost always the effect was positive. There was only one case when Akatinol Memantine gave the opposite effect (Talked to medical representative of the manufacturer in this regard. It's like going to Japan to conduct research for the study of this issue). In two patients, the effect was not observed even when the maximum dose. And in one patient clear mind comes in waves. All the rest have changed in unbelievable way. Some of them every year come to me for advice or just to say thank you. You can buy Akatinol.

"I had a very interesting case. Treated me lady 73h years. Cognitive average severity of the disorder. And the family is heavy, and it (but she does not understand). Native is not periodically learned, was written at the corners, did not live in our time. Grandma treat, recommendations on the house painted. After 2 months, the children came. they told me that their mother again is a social way of life. But the most "unpleasant" remembered that her sons for 30 thousand have "

Barbara, 28 years, Akatinol Memantine appointed my child to a children's neurologist. Propyl month. The doctor extended course for another three months. By now familiar flew to Moscow and I was asked to bring a large package Akatinol Memantine, the same Table 90. At the end of the course, I noticed that the child was more than call some syllables and words, and even began chants)). He became a child perseverance in the classroom with a speech therapist. Many drugs have a delayed effect that is manifested after a certain time after receiving treatment. Apparently, due to the fact that the course we have been long, the effect began to manifest itself in the application of this preparation.