Actovegin tablets - Instructions for Use, Dosage, Side Effects, Reviews

Synonyms: Solcoseryl

Active substance: Deproteinized hemo-derivated of calf blood

ATC - B06AB Other hematological agents.

Pharmacological group - Antihypoxants and antioxidants; Angioprotectors and proofreaders microcirculation; Regenerants and reparants.

Nosological classification (ICD–10)

I25.2 Transferred last myocardial infarction;

I63 Cerebral infarction;

I67.9 Cerebrovascular disease, unspecified;

Effects of cerebrovascular diseases;

I73.9 peripheral vascular disease, unspecified;

I79.2 Peripheral angiopathy in diseases classified elsewhere;

I87.2 Venous insufficiency (chronic) (peripheral);

I99 Other and unspecified disorders of the circulatory system;

L58 radiation dermatitis radiation;

L89 Decubital ulcer;

L98.4.2 * skin trophic ulcer;

S06 intracranial injury;

T14.1 Open wound of unspecified body region;

T30 Burns and corrosions of unspecified site;

T79.3 Post-traumatic wound infection, not elsewhere classified.

Actovegin Composition, structure and packing

Coated tablets greenish-yellow, round, brilliant.

Actovegin Pharmacological action

Antihypoxant represents Hema-derivated which is prepared by dialysis and ultrafiltration (permeate compounds with a molecular weight less than 5000 daltons).

Increases deposit of glucose by cells, increases oxygen consumption increases oxidative phosphorylation in mitochondria, thereby increasing the level of ATP and normalizing metabolism and the energy balance of the cells in tissues.

Actovegin increases the concentration of ATP, ADP, phosphocreatine, and amino acids (glutamate, aspartate) and GABA.

Effect of the drug Actovegin on the assimilation and utilization of oxygen, as well as insulin-like activity with the stimulation of glucose transport and oxidation are important in the treatment of diabetic polyneuropathy.

Patients with diabetes mellitus and diabetic polyneuropathy Actovegin significantly reduces symptoms of polyneuropathy (stabbing pain, burning sensation, paresthesia, numbness of limbs). Objectively reduced sensitivity disorders, improves mental well-being of patients.

Actovegin effect begins to appear no later than 30 minutes after ingestion, and reaches a maximum on average after 3 hours (2–6 hours).

Pharmacokinetics

Through pharmacokinetic study the possible methods pharmacokinetic characteristics (absorption, distribution, elimination) of the active drug components Actovegin because it consists only of physiological components which are normally present in the body.

Hitherto not found Hemoderivated reduce pharmacological efficacy in patients with altered pharmacokinetics (including with hepatic or renal failure , metabolic changes associated with advanced age, due to the peculiarities of metabolism in newborns).

Actovegin Dosage

Assign inside of 1–2 tab. 3 times/day before meal. Do not chew the pill, washed down with a little water. Duration of treatment is 4–6 weeks.

In diabetic polyneuropathy Actovegin introduced in/2000 mg/day for 3 weeks followed by a transition to the drug in tablet form - 2–3 tablets. 3 times/day for at least 4–5 months.

Actovegin at Pregnancy and lactation

With careful use of medication during pregnancy and lactation.

Actovegin Side effects

Allergic reactions: urticaria, edema, drug fever.

Actovegin Indications

In the complex treatment of metabolic and vascular disorders of the brain (the various forms of cerebrovascular insufficiency, dementia, traumatic brain injury);

Peripheral (arterial and venous) vascular disorders and their consequences (angiopathy, trophic ulcers );

Diabetic polyneuropathy.

Actovegin Contraindications

Hypersensitivity to the drug or similar drugs.

Precautions should be prescribed the drug for heart failure stage II-III, pulmonary edema, oliguria, anuria, overhydration, during pregnancy and lactation.

Actovegin Cautions

With the development of allergic reactions should discontinue receiving Actovegin. If necessary, a standard therapy of allergic reactions (antihistamines and/or corticosteroids).

Actovegin Reviews

Anne, 31 years, With drug Actovegin I met at the last stage of pregnancy, when giving birth to was still two months. Doctor on US defined premature aging of the first degree of the placenta and my precinct appointed me Actovegin tablets, explained that it is necessary to drink them to improve the supply of oxygen to the child that he is bad, do not have enough oxygen.

I was upset, it is not enough oxygen? Even if the doctor and was wrong, I still went to the pharmacy for pills. What I did not expect to hear it because the price of 300 USD. Nothing can be done, either in my place would have been their drink, suddenly they really need and will help the child. The other girls, I heard, put a dropper with Actovegin in day care, and the drip too much cost, one pregnant even told me that she felt worse after a few droppers, which is very strange, something is wrong here.

I'm cutting tablets Actovegin course, I will not say that I have something changed in my well-being, rather, that the saw that there was no - the same way. I hope only that helped the child, and in no way to check. Is that the baby was born healthy, everything was normal, without deviation, but whether there is merit in this Actovegin I could not understand.

Samanta 28 years, Apparently surge two months ago began to hurt my eyes, there were problems with the perception of information on the monitor. From time to time there is a feeling that the things for which I look, swim towards them and I essentially do not see, although they should have been in my field of vision. The doctor has appointed single intravenous injection of the drug Actovegin together with saline. The whole course of treatment was 10 droppers. Throughout the treatment of any adverse effects of the drug experienced.

By the end of the treatment felt that my sight is restored, interference in the form of floating in the eyes of broken lines are gone, the book is well defined lines of text, the letters are clearly visible. We can conclude that Actovegin effective drug. Its major drawback, in my opinion, is the high cost. Typically, for a complete deliverance from disease requires multiple courses of treatment, and with high prices for the drug to get the required number of courses is not possible for our needy patients.