Mildronate in sports

Mildronate in capsules

Mildronate (meldonium, kardionat) – is a preparation that improves metabolism and energy supply of tissues prescription. The product was created in the 70-ies of XX century in the Institute of Organic Synthesis of the Latvian SSR, engaged in the development by Professor Ivar Kalvins. Initially the compound was patented as a means to control plant growth and stimulation of growth of animals and poultry.

WADA is considering mildronats as a metabolism modulator, similar to insulin. A study published in December 2015 in the journal Drug Testing and Analysis, argues that meldonium increases of athletes, endurance, improves recovery after the performance, protects against stress and increases the functional activity of the central nervous system. Thus these effects have been confirmed mainly only Latvian scientists.

On January 1, 2016 meldonium has been added to S4 class (hormones and modulators of metabolism) Prohibited List and is prohibited for use in the competition and contest season.

Effects of Meldonium inBodybuilding

• Mildronate prevents accumulation of activated cells in unoxidized form fatty acids.
• In conditions of ischemia meldonium restores the balance of oxygen delivery and consumption processes in the cells, to prevent violations of transport ATP.
• THP activates glycolysis, which proceeds without the use of supplemental oxygen.
• MET – 88 improves muscle power.
• Mildronats increases the effectiveness of training
• Quaterine reduces fatigue.
• Mildronate protects the heart and improves myocardial contractility.

Note Bene:

Mildronate (meldonium) has cardioprotective, anti-anginal, anti-hypoxic, angioproteguoe action. Is structural synthetic analogue of gamma-butyrobetaine - carnitine precursor. It inhibits the enzyme y-butyrobetaine hydroxylase carnitine reduces the synthesis and transport of long chain fatty acids across cell membranes and prevents the accumulation of cells in the activated forms of non-oxidized fatty acids (including acylcarnitine blocking delivery of ATP to cell organelles). Improves metabolic processes. When ischemia prevents violation of transport and ATP activates glycolysis. As a result of reducing the synthesis of carnitine in the cell increases the content of y-butyrobetaine, has vasodilating action. Against the background of heart failure improves myocardial contractility, increases exercise tolerance. Increases cellular and humoral immunity. It increases efficiency, reduces the symptoms of mental and physical stress, enhances stamina. If ingestion is well absorbed from the gastrointestinal tract. Bioavailability - about 78%. Maximum plasma concentration is achieved in 1-2 hours half-life -. 3-6 hours Side effects -. Dyspepsia, agitation, tachycardia, hypotension, pruritus. The average dose for adults at intake - 250 mg 2-4 times a day.