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Sports Pharmacology – Pharmacology stages of preparation

19 Oct 2016

Base period

Aims and objectives of this period:

- Bring to the maximum amounts of general and special health;

- Reduce the impact of adverse factors of the training process in the internal organs;

- To prevent overtraining;

- Create the optimal amount of muscle without prejudice; for endurance and speed qualities;

- Psycho-correction status.

Kinds of sports Preparations of plastic action Energy Vitamins Nootropics Antioxidants Antihypoxants Immunomodulators Adaptogens
Endurance ++ ++ +++ ++ ++ + ++ ++
Speed and power ++ +++ ++ + + + ++
Martial Arts + + + +++ + + + +
Coordination + + ++ + ++
Game + ++ ++ ++ + + ++ ++

The basic phase of training is characterized by significant volume and intensity of training, so in this period have to make the greatest number of drugs. Reception of vitamins, although it is advisable to make a 8-10-day break in the course intake of multivitamin complexes, and if there is an opportunity to start taking a new vitamin preparation. From individual vitamins expedient appointment of Cobamamide and Vitamins B Complex that enhances the synthesis and prevent the collapse of the muscle proteins.

Vitamin B15 is required immediately after a workout. In order to prevent disruption of adaptation to physical activity and prevent overtraining - sport's disease - recommended the appointment of drugs with antioxidant, antihypoxic properties; cardiovascular agents and agents that improve the rheological properties of blood; Succinic acid, Stimol to reduce levels of lactic acid; sedatives (valerian). Needed medications that promote ATP synthesis, stimulation of processes of cellular respiration. Action antihypoxants increases emotional stability and physical performance.

During the developing of physical activity recommended to the administration of drugs that regulate the exchange of plastic, ie, stimulating protein synthesis in muscle tissue, promoting increase in muscle mass, reducing effects in cardiac muscle dystrophy. This group of drugs include: Elcar, Mildronate, Cobamamide, Potassium Orotate (by orotic acid), Leuzea, Ecdisten and others.

During the base preparation phase also recommended the appointment of hepatic, reception of Riboxin (Inosine), Actovegin. Nootropic drugs are used at maximum load, typical of this period, not to "break technique", ie It remained dynamic structure-established stereotypes. Psychotropic drugs are recommended by a psychologist, for example Semax, Phenotropil, Noopept, Picamilon, Vinpotropile, Pantogam.

Admission of Immunomodulators during this period is essential to prevent failure of the immune system. The focus of the diet during this period - protein and carbohydrate. Protein should be a full (well-balanced amino acid composition, easily digestible). The amount of protein to take additional, should not exceed 25-40 g per day (based on the pure protein). Essential amino acids are required in any form.


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Sports Pharmacology – Pharmacology stages of preparation

19 Oct 2016

Preparation period

The main objective of the pharmacological provision in the preparatory phase is to prepare for the perception of intense physical and psycho-emotional stress.

Kinds of sports vitamins Energy drugs Adaptogens Nootropics Antioxidants Immunomodulators
Endurance ++ ++ + ++ +
Speed and power ++ ++ ++
Martial Arts + + + ++
Coordination + + + ++
Game ++ ++ ++ ++ + +

The pharmacological aspects of this problem is solved by the following preparations.

Multivitamin complexes such as Cîmplivitum, Aerovit, Glutamevit, Supradyn, Centrum, Animal Pak, Vitrum and others are specialized preparations containing, along with a complex of vitamins balanced trace element composition, so their use is in the preparatory period is the most preferred, helps to normalize the flow of biochemical reactions body.

Admission of Ginseng, Siberian Ginseng, and others. They accelerate adaptation to heavy physical activity and normalization of the functional state of organs and systems. Admission of Adaptogens should be started 3-4 days before the start of training.

Vitamins A and E - either individually or in combinations "Aevitum" preparation - contribute to the stimulation of Redox processes and synthesis of certain hormones.

Vitamin C (for example, sea buckthorn and honey) are used to accelerate the adaptation to physical stress.

In order to normalize the metabolism prescribe the following drugs – Mildronate, Riboxinum, Inosine, Essentiale, hepato-protectors. Recommended iron supplements "Ferro-Plex", "Conferon", "Aktiferrin" etc. To create favorable basic training background.

Calming and sleeping medicines used in the second half of the period for the prevention and treatment of the syndrome surge of the central nervous system after a significant psycho-emotional stress. You can use the roots of valerian (infusion, pills), infusion of Leonurus, Neurobutal, sodium hydroxybutyrate (1-3 tablespoons of 5% solution for 30-40 minutes before bedtime), Mebicar and some other anti-anxiety drugs.

Use the principle of saturation carbohydrate (energy replenishment) directly from training.

The diet should be rich in carbohydrates and fats (unsaturated). To a lesser extent this applies to proteins. Absolutely requires the presence in the diet of fresh fruits and vegetables, juices and foods high biological value. Particular attention should be paid to the weight of the athlete, who in this period should not exceed the usual, so-called "combat" more than 2-3 kg. In the second half of the period, we recommend taking immunomodulators, preferably non-specific, such as mummies, honey with pollen, pollen, enzymes.


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Sports Pharmacology – Management of Athlete’s working capacity

19 Oct 2016

Additional risk factors

• Regime and its violation

- Possible failures: rest, sleep, jetlag, "winter", "summer" time and a "violation of the regime."

• Diet

- Diet does not correspond to the sport;

- Unbalanced energy (kcal);

- There is compliance training process (carbohydrate period during protein);

- Unbalanced intake of protein, fat, carbohydrates;

- No carbohydrate feeding in training;

- Not complied with the meal (mode);

- Incompatibility of food ingredients;

- Indiscriminate consumption of mineral water;

- The consumption of contaminated water. Diet pro complies with all 365 days of the year, not only in preparation for a competition.

Hypovitaminosis, lack of minerals

• Intoxication:

Alcohol

- Decreases the speed of complex motor reactions, accuracy muscular effort;

- There is an imbalance of excitation and inhibition in the CNS;

- Decreases the accumulation of glycogen in the liver; at high loads a high risk of hepatitis B;

- Adversely affects the exchange of B vitamins, trace elements;

- Increased blood clotting;

- Possible dystonia;

- Tachycardia;

- Slow down the recovery process;

- Reduced volitional qualities of the athlete.

Smoking (including passive)

- Growth slows down in adolescence;

- Reduced mental and physical performance;

- Decreases the speed of complex motor response, accuracy muscular effort;

- 10% decreases the ability to absorb oxygen and hence increases the load on the heart;

- Reserves are exhausted vitamins C, E, A;

- Increased tendency to spasm of blood vessels;

- Increased susceptibility to diseases of the bronchi, lung, gastric mucosal damage due.

Household intoxication

-household chemicals;

- Poor-quality drinking water;

- Nitrates in the products.

Professional intoxication

- Chlorine - swimming;

- For breathing mixture - scuba diving;

- Powder gases - bench, shooting;

- Synthetic coatings - halls, paths; Other.

• Air pollution

Athletes who train in urban environments, are influenced by various pollutants that may have an impact on athletic performance. Especially pernicious exercise near industrial plants, roads. The most common air pollutants: carbon monoxide, ozone, sulfur oxide, nitrogen oxide and peroxide acetyl. (Some information about Phenotropil pills)

Sports facilities (stadiums, sports palaces, gymnasiums, the venue of the competition) must have a passport with an indication of the environmental concentrations of certain substances in the course of the day. Accordingly, one can calculate the damage caused to the health: the concentration of the toxic substance, multiplied by the volume of lung ventilation, multiplied by the respiratory rate.

• Outbreaks chronic infection (Ochi)

- Caries;

- Asymptomatic or low-symptom disorders of the ear, nose, throat, liver, kidney, intestines;

- Fungal skin lesions.

• Dysbacteriosis

• Invasion of morbidity

• Infection (acute)

• Clothes, shoes

- Injuries, flat, scoliosis, osteochondrosis, osteoporosis, overheating, frostbite, etc...

• Inventory, protective equipment

- injury

• Environmental factors:

Heat

- Dehydration, heat illness, injuries.

Cold

- Dehydration, hypothermia, frostbite.

Highlands

- Dehydration, hypothermia, overtraining

• Iatrogenesis

At sufficiently high athlete raising a number of issues of biomedical orientation.

Medications - danger of intoxication

- Unwarranted use - not on the testimony;

- Failure to comply with dosage;

- Polypharmacy, ie the appointment of a large number of preparations (in this case - antagonism, potentiation);

- Doping.

• Limited and non-systemic use of preventive, curative, rehabilitation funds in the annual training cycle

Every time there is no dynamics of athletic performance at a certain time interval, it is necessary, using the table in this chapter classification management capacity for work, to identify the reasons preventing the increase of efficiency. Knowing the cause, you can try to fix it.


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Sports Pharmacology – Management of Athlete’s working capacity

19 Oct 2016

Factors constraining the performance of skilled athlete

There are factors influencing that may reduce or increase the efficiency of a healthy body.

These factors can be divided into two groups: system and organic:

Limiting by systemic factors:

  • Lack of functioning (imbalance) of the endocrine system

The reason: a wide range - from genetic to infectious diseases, as well as doping.

Impact: The violation of all types of metabolism (metabolic imbalance).

Identification and control: hormonal profile.

Correction: According to identify the causes.

  • Violation of the acid-base status and ion balance in the body

Reason: work glycolytic mode, anemia, lack of bicarbonates.

Impact: a change of the buffer capacity of the blood, the accumulation of lactate acidosis.

Control: La-blood pH blood, hemoglobin, blood.

Correction: Increase the buffer capacity of the blood, alkalization, reducing lactic acid levels. Iron preparations, calcium, potassium, phosphorus, enzymes.

  • Blocking of cellular respiration in working muscles

Reason: violation of electrolyte transport in the respiratory chain, and a lack of violation of transport phosphocreatine.

Consequence: reduction of work capacity due to decreased muscle contractility.

Control: the concentration of creatine phosphokinase (CPK).

Correction: macroergs, phosphogen, respiratory enzymes antihypoxants, iron supplements.

  • Reduced muscle energy

The reason: lack of glycogen, ATP, phosphocreatine, lipids, proteins.

Consequence: reduction of work capacity due to decreased muscle contractility.

Control: basal metabolism, glycemic profile, sports biochemistry, ECG.

Correction: carbohydrate saturation. Initiation of carbohydrate and lipid metabolism, phosphocreatine. Neoton, Mildronate, Neurobutal, Sodium Hydroxybutyrate, Antihypoxants.

  • Launch of free radical processes in the result of limit loads

Reason: exorbitant exercise. Lack of antioxidants. The formation of toxic products (pro-oxidants).

Impact: The violation of mitochondrial functions of cell membranes.

Control: determine the level of peroxidation (LPO) by chemiluminescence.

Correction: antioxidants.

  • Violation of the microcirculation. Change of rheological properties and blood clotting

Reason: prohibitive exercise under adverse external factors, which leads to damage of the vascular endothelium, triggers an imbalance of the coagulation-anticoagulation system.

Consequence: tissue hypoxia. The development of disseminated intravascular coagulation (DIC). Violation of the functions of internal organs: heart, liver, kidneys, etc...

Control: blood pH, hematocrit, coagulation, differential blood cell count, urinalysis, electrocardiogram.

Correction: the preparations improving microcirculation and blood rheology: Actovegin, Solcoseryl, Trental, Pentoxifylline,Ttanakan, aggregation inhibitors (Papaverine, Euphyllin), and so on.

  • Reduction of immunological reactivity

Reason: prohibitive exercise, meteoklimaticheskie adverse conditions.

Impact: The susceptibility to infection by any infectious disease.

Control: immunological control.

Correction: immunomodulators, enzymes, adaptogens, biostimulants

  • Inhibition of the central nervous system and peripheral nervous system

Cause: The load that extends beyond the physiological norm.

Consequence: overtraining - "Sport disease", a violation of the dynamics of the psychological state of the athlete.

Control: psychos, the starting time of the reaction, the speed of the pulse.

Correction: psycho-sedative, tranquilizers, means correcting sleep disorders, agents that hinder the involvement of emotions in the autonomic centers.

Limiting by organ factors

  • Reduction of myocardial contractility

Monitoring: ECG, echocardiography, functional tests.

  • The weakening of the respiratory function

Control: peak speed of exhaled air (peak flow), forced vital capacity (FVC).

  • Reduction of the liver, kidneys and other organs as a result of prohibitive training load

Control: Ultrasound, rheography, biochemistry, etc...

  • Damage (injury), muscles, ligaments, joints

Control: traumatologist.

Furthermore, in the analysis, performance monitoring and correction systems leading body must be considered and their generalizations properties:

- Backup features - capacity;

- Feasibility - power and mobilized;

- Effectiveness - efficiency.


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Sports Pharmacology – Management of Athlete’s working capacity

18 Oct 2016

Energy Areas

Energyu substrate to provide the basic functions of muscle fibers - reducing it - is adenosine triphosphate - ATP.

Power supply for the implementation of the methods conventionally divided into anaerobic (alaktic - lactate) and aerobic.

These processes can be summarized as follows:

Anaerobic energy area:

ADP + phosphate + free energy of ATP <=>

Phosphocreatine + ADP + ATP Creatine <=>

2 ADP <=> AMP + ATP

Glycogen (glucose) + phosphate + ADP + ATP lactate <=>

Aerobic zone of energy supply:

Glycogen (glucose), fatty acid O2S02 + phosphate + H 2 0 + + ATP.

Energy sources are Phosphogen, Glucose, Glycogen, Free Fatty Acids, Oxygen.

Introduction of ATP from outside in sufficient doses cannot be provided (the reverse is a common misconception), therefore, it is necessary to create conditions for the formation of increased amounts of endogenous ATP. This is the aim training - shift metabolic processes towards the formation of ATP, as well as the provision of ingredients.

The rate of accumulation and power consumption vary considerably depending on the functional state of the athlete and the sport. Some contribution to the energy supply process, its correction is possible by the pharmacy.

In the early 70's it was demonstrated that the reduction in ischemic myocardium stops cell exhaustion of reserves phosphocreatine (PC), despite the fact that the cells remained outstanding about 90% of ATP. These data indicate that the ATP is not evenly distributed within the cell. Accessibility is not all ATP contained in the muscle cell, but only a small part of which is localized in the myofibrils. The results of research carried out in the following years, showed that the relationship between intracellular ATP pools performed FC and iso-enzymes creatine kinase.

Under normal conditions, the ATP molecule derived from the mitochondria, transfers its energy to creatine, which is under the influence of mitochondrial creatine kinase isoenzyme transformed into FC. Last migrate to sites of local creatine reactions (sarcolemma, myofibrils, sarcoplasmic reticulum), where other isoenzymes of creatine provide resynthesis of ATP from ADP and FC.

Exempt with creatine returns to the mitochondria, and ATP energy is used for its intended purpose, including for muscle contraction. The rate of energy transport within the cell by way fosfocreatinic ATP significantly exceeds the rate of diffusion in the cytoplasm. That is why the reduction of FC in the cell and leads to depressed contractility even while maintaining a significant intracellular stock of the main energy substrate - ATP.

According to modern concepts, the physiological role of the FC is to provide energy efficient intracellular transport from places of production to places of use.

Under aerobic conditions, the main substrates for the synthesis of ATP are free fatty acids, glucose and lactate metabolism which normally provides for the production of about 90% of the total amount of ATP. In a series of successive catalytic reactions of the substrates is formed of acetyl-coenzyme A. Inside of the mitochondria in the tricarboxylic acid cycle (Krebs cycle) cleavage of acetyl coenzyme A to carbon dioxide and hydrogen atoms. Recently transferred to the electron transport chain (respiratory chain) and are used for the reduction of molecular oxygen to water. The energy produced when transferring electrons along the respiratory chain, oxidative phosphorylation as a result of being transformed into the energy of ATP.

The reduction in oxygen delivery to the muscles leads to rapid decomposition of ATP to ADP and AMP, and then the collapse of AMP to Adenosine, Xanthine and hypoxanthine. Nucleotides located over sarcoplasmic membrane into the extracellular space, making it impossible to re-synthesis of ATP.

In hypoxic conditions intensified the process of anaerobic ATP synthesis, the main of which is a substrate for glycogen. However, during the anaerobic oxidation of ATP produced much smaller molecules than for aerobic oxidation of metabolic substrata. ATP is the energy of the synthesized under anaerobic conditions, not only is insufficient for contractile function of the myocardium, but also to maintain gradients of ions in the cells. Reducing the content of ATP is accompanied by a decrease in the content of a leading FC.

The same way Mildronate operates.

Activation of anaerobic glycolysis results in the accumulation of lactate and acidosis development. The consequence of the deficit-energy phosphates and intracellular acidosis is a violation of the ATP-dependent ion transport mechanisms responsible for the removal of calcium ions from the cell. The accumulation of calcium ions into the mitochondrial uncoupling leads to oxidative phosphorylation and increased energy deficit. The increase in calcium ion concentration in the sarcoplasm ATP deficiency promotes the formation of solid actin-myosin bridges, which prevents relaxation of myofibrils.

ATP deficiency and excess calcium ions combined with increased production and increased muscle content stimulates catecholamine "lipid triad". Development of the "lipid triad" cause destruction of the lipid bilayer of the cell membrane. All this leads to a contraction of myofibrils and their destruction. The role of the "trap of calcium ions" perform inorganic phosphate and other anions accumulate in the cells during hypoxia. Mildronate can improve it.

Pharma - providing into zones is as follows:

In anaerobic (alaktatic) for providing high speed zone, as powerful as possible, a short run (a few seconds), introduced phosphogen particularly Neoton.

In anaerobic (lactate) zone to the accumulation of lactic acid in the submaximal power the body should also be provided with phosphocreatine, maximum provided the ability to completely dispose of the oxygen tolerate oxygen debt (antihypoxants), dispose of "waste" and have glycogen stores and the ability to fill in the work carbohydrate reserves.

In aerobic (oxygen) zone must provide: a continuous supply of carbohydrates into the blood stream, the maximum oxidation of fatty acids (lipotropics) and formed with neutralization of free radicals (antioxidants), and the maximum utilization of oxygen entering the body (antihypoxants).


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Sport pharmacology maximum effect without any damage to health - this is real? Part 3

18 Oct 2016

In my opinion, this article is more of a familiarization character, than giving readers the exact recommendations for the pharmacological provision in this or that situation. The article does not have enough technique the use of drugs in various stages of preparation. The author informs that have different pharmacological agents, for which they are intended, but how to apply them - not said. If the author has tried to offer a methodology (or to share their own experiences with even one of the drugs), to give practical advice to paint the use of certain drugs in certain cases, the material would be more popular. But the information on the use of pharmaceuticals has long acquired a commercial painting, and even the most simple pattern of use costs money, so no one person will not just reveal all the cards.

However, the information in this article has the right to its existence, as written on the basis of already published works and is in its own way an attempt to systematize the existing scientific methodological material. However, in this case it would be better to reinforce the text links to the literature, as is usually done in scientific journals.

Dangers in the use of drugs and methods of their use, mentioned in the article, I do not see. There are just such preparations are no longer available or, for example, those for which now may disqualify. For example, Ðhosphadenum you have nowhere to be found in pharmacies, so it can be easily expunged, Mildronate is banned for all kind of sports, and Instenon in some sports such as shooting, now banned by WADA (in ski racing it is not detected, but may disqualify the athlete if there is evidence the use of this drug - ).

If we talk about the need for the use of pharmacological agents in sport, but now everything is already aware that it is an integral part of physical perfection. The question is only, what purpose people engaged in sports. If in order to achieve high sports results, it is obvious that one can not do any highly qualified athlete without pharmacology. If for yourself, that is, for health, everyone defines how it advisable to seek the help of pharmaceuticals. Personally, I do not see anything wrong. If an athlete to aim high, then no pharmacological correction is not enough here. Of course, when it comes to the recovery period, April or May, then it is not as useful if, of course, there is little evidence of medical control, but with an increase in the training, and then the competitive load this need more and more increasing.

Personally, I believe that the use of pharmacological agents in the process of training - it is absolutely normal. Even an ordinary person from time to time it is necessary to use vitamins B, A and E as well as iron, ascorbic acid, etc., To say nothing about the athletes, constantly experiencing great physical exertion? .. Just pharmacological provision should be carried out under the supervision of specialists, and not, as we have made, "the more, the better." It is necessary to use pharmacological agents with intelligence, periodically do blood chemistry control, examined by sports physicians, and then the problems will be less. In a word, I would say that's not so bad use of Pharmacology as uneducated people, and uncontrolled use of various drugs.

I would also like to point out that someone coping with physical activities and shows good result, and someone has already reached its limit and can not continue to develop, and it is necessary, for example, to make a qualitative leap before important competitions. Many athletes, there comes a time when, sooner or later, they are forced to turn to pharmacology, including forbidden to continue to improve. When an athlete realizes that his own forces and the reserves of the body it is not enough to achieve the desired result, it is inevitable. In such cases, often the person and starts taking illegal drugs and exceed the standards of what is permitted for the body.

Here the author, for example, writes: "The athlete receiving a doping consciously, does not understand what harm it causes to their health." No, he knows, and he goes to consciously take this risk, because he has great, with nothing comparable to the desire to achieve a good result. Health - this is not important, but he does not believe that something could happen to him. He gets a kick out of it stronger than the other, from the fact that he stands on the podium above, it receives the highest moral satisfaction, that he would never bring awareness of themselves just a healthy person. But this is not a "victim". He has no regrets about the dangers to health. It's just that professional athletes completely different psychology. It comes to them consciously. They are working on the result. Deprivation of opportunity to improve and fight for the medals can lead to disastrous consequences: remember the tragedy of the famous Italian cyclist Marco Pontani, committed suicide at the age of 34, due to the fact that he was first tortured doping test and then banned from performing in the competition.

The article also contains the following words: "Sport Pharmacology - a reasonable alternative to doping." You know, maybe I'll tell you a shocking thing, but not always a drug conjugate to harm health. My very dear colleague, Sergey V. Erdakov all his life to cycling and who has spearheaded the emergence of professional cycling races in Russia, has analyzed the longevity of athletes who participated in the largest cycling world. They were 50-70-ies, it had not yet had such control of doping, as it is now, so athletes are used in the preparation of everything that could be used. It turned out that the winners of major races like the Giro d'Italia, Tour de France et al., Lived almost to 90-100 years old! What has been said in some way leads to the conclusion that the use of performance-enhancing drugs - is not always harmful to the human body. Referring to the observations of the day, the use of performance-enhancing drugs, namely, illegal drugs, including erythropoietin, anabolic steroids had no effect on childbearing and life expectancy of the famous athletes, including Russian skiers.

Of course, a moral and ethical point of view, the use of illegal drugs is wrong and dishonest act against other athletes, but life practice dictates strict rules ... Doping remains always on the conscience of the athlete.


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Sport pharmacology maximum effect without any damage to health - this is real? (Continue)

18 Oct 2016

Recovery period

In the recovery period, which lasts from about April to June, it is important to give your body rest and recover after a long ski season. This is the only time of year when the conscious skier can afford, say, eat a sandwich with butter, soup with sour cream, as well as the train gently (at the same time it is necessary to ensure that the weight does not exceed the "combat" rate more than 3.5 kg). In addition to physical recovery, this is the place to be unloaded and moral: do not have to constantly think about the competitions, about training plans - you just enjoy waking up from winter sleep outdoors gradually to get used to the Cross and forget about all the intensity. In the spring it is not necessary to hurry - in the summer you have "oncoming" and do not have time to look back, as will jump simulation.

In terms of pharmacological maintenance comes to the fore removing "toxins" from the body that have accumulated as a result of heavy training and competitive pressures, as well as due to the use of pharmacological agents for the entire year. A significant part of the "toxins" accumulated in the liver, so it is advisable to carry out preventive course of hepato-protective drugs. Much attention should be paid to saturate the body with vitamins and a variety of bio-elements. To solve these problems apply vitamins A and E that contribute to the stimulation of certain Detox processes and the synthesis of some hormones. Vitamin C, which is used to accelerate the adaptation to physical stress and for the purpose of preventing beriberi. For women, we can recommend the drug Ferrîplåõ (Hungary), in addition to containing Ascorbic Acid, iron ions. Some vitamin complexes help to normalize the flow of biochemical reactions in the body, prevent the development of beriberi, others - are specialized sports preparations containing vitamin complex along with a balanced trace element composition. Their application is the recovery period is the most preferred.

Accelerating adaptation to stress and normalization of the functional state of organs and systems facilitates the reception of Adaptogens such as Safinor, Ginseng, Siberian ginseng, devil's-club. Admission of Adaptogens should be started 3-4 days before the start of training, duration of supplementation is usually 10 to 12 days. Calming and sleeping medicines used in this period, mainly for the treatment of CNS suppression and surge syndrome, after considerable psycho-emotional overload that occurred during the season. Valerian roots can be used (as in tablet form or in the form of infusions), Motherwort Infusion, Afobazol and some other anti-anxiety drugs.

With a view to the normalization of metabolism in the recovery period for the regulation of the functional state of organs and systems, to speed up the rehabilitation of athletes is prescribed as a rule, the following drugs: Riboxin (Inosine), Cocarboxylase, Essentiale, hepato-protectors Allochol, Legalon and others.

Preparation Period

But over the spring and you have to rearrange the attachment with skis on rollers. This means nothing else than the fact that the summer came - preparation stage, referred to as basic or preparatory. From June to September skiers inject a horse, because, as they say, "that have built up in the summer - it will show in the winter." This period is characterized by the highest saturation of pharmacological, since there is a high probability overload body.

In the preparatory period it continued taking vitamins, although it is advisable to make a 8-10-day break. Well, if an athlete has the opportunity to start taking a new drug.

From individual vitamins expedient appointment Ñîbàmàmid and vitamins B complex that enhances the synthesis and prevent the collapse of the muscle proteins. Also, B vitamins act as cofactors in various enzyme systems associated with the oxidation of energy supply and the formation of products. In the preparatory period recommended the appointment of some drugs with antioxidant properties - Encephabol, Mildronate, Ubione, Alpha-Tocopherol Acetate, Gammalon, Lipoic acid, Sodium Succinate. Taking these drugs contributes to the synthesis of ATP in the brain, stimulates cellular respiration, has anti-hypoxic action (which is especially useful during training in conditions of middle) enhances emotional stability and physical performance of athletes.

What is the "anti-oxidant" and "anti-hypoxic" action? Oxygen is z vitally necessary element, but it is very active and easily reacts with many substances, including harmful to the human body. In the process of cellular respiration, energy authorizing body, some oxygen molecules react, resulting in the formation strong oxidants (free radicals) such as superoxide and hydrogen peroxide. They are unstable compounds rich in the "extra" energy, so getting into certain cells in the body, they come in a variety of reactions that disrupt the normal functioning of these cells. Danger them is that they damage the "healthy" molecules involved in metabolism, alter DNA structure, in which the genetic information is stored, are involved in the synthesis of the harmful cholesterol. It is believed that thereby the free radicals may contribute to diseases such as cancer and atherosclerosis. Scientists also believe that the damage caused by free radicals is the basis for the aging process.

High physical activity, especially in professional sports, leading to an increase in the number of free radicals in the body, which affects the strength, endurance, recovery time. The antioxidant effect of certain pharmacological agents just aimed at neutralizing free radicals. For this purpose, it is recommended to use an additive containing manganese, zinc, copper, selenium and vitamins C, E, B2, B3, B6 and beta-carotene. Also, sources of antioxidants may be, for example, plants (blueberry and grape seeds), germinated grains and fresh fruits and vegetables. It is also an important role in protecting the body from the harmful effects of hypoxia play anti-hypoxant: Actovegin, Solcoseryl, Sodium Oxybutirate, Olyphenum (Hypoxenum), Cytochrom C.

During the developing of physical activity is very useful medications that regulate the exchange of plastic, ie, stimulating protein synthesis in muscle cells, contributing to an increase in muscle mass. This group of so-called anabolic agents include Ecdisten, Carnitine Chloride, Carnitini chloridum and others. Although steroid structure Ecdisten devoids of side effects of testosterone preparations and anabolic steroids. Even long-term use of it does not affect the content of the main hormones of the body. Ecdisten desirably used in combination with B vitamins or a multivitamin complexes.

The preparatory phase of the annual cycle of training is characterized by significant volume and intensity of training loads. That is why the reception of immunomodulators in this period is a prerequisite to prevent disruption of the immune system. The most affordable and common in our country are such nonspecific immunomodulating agents like mummy, honey (cell, preferably in an old dark cells), pollen, as well as all known Immunal. The most important condition for their applicability is fasting (preferably in the morning). However, we must remember that immunomodulatory drugs are particularly important in the precompetitive and especially in the competitive period of training, when the body's immune system is weakened due to the acquisition of the physical form. In those moments when we are "at the peak", the slightest infection or a common cold can be the beginning of the disease.

Precompetitive Period

From October begins the period of preparation for precompetitive period for skier racing, when he gets up in the snow. This period lasts until December-January and in terms of pharmacological support is characterized by a significant narrowing of the spectrum of the drugs. It is recommended to reduce the intake of multivitamins (possibly better to change the drug used). From individual vitamins and coenzymes again expedient appointment of Ñîbàmàmidum to prevent the fall of muscle mass and Cocarboxylase the purpose of the regulation of carbohydrate and lipid metabolism, as well as vitamin C.

At the beginning of precompetitive period can be recommended is already familiar to us from the preparatory period of preparations, such as Mildronate, Ecdysten, Carnitine Chloride, Sodium Succinate, etc.

But the dosage should not exceed 1/2 of the dose of the preparatory period. For 5-7 days before the competition, these drugs should be abolished. In the second half of the precompetitive period (8-10 days before the start) we recommend taking adaptogens and energy-rich products: Mildronate, ATP Fosfobion, Creatine, Ðhosphaden, Neoton etc. If adaptogens help to accelerate the processes of adaptation to changing environmental conditions (because of competition usually occur on leaving the country, the country, city, etc.) and accelerating the recovery process, the high power products and preparations you can create an "energy depot ', promote the synthesis of ATP and improving muscle contractile capacity.

It should be noted that there are also physiological anabolism stimulators ( "fusion"), for example, short-term fasting (no more than 24 hours) and cold load, which promotes protein synthesis in the body and increase muscle strength. As a result of cold adaptation increased parasympathetic tone with increased Acetylcholine synthesis, which is a major mediator of the neuromuscular system (Choline Chloride - acetylcholine precursor, reinforcing structures cholinergic activity) increases the level of adrenaline and Noradrenaline, which leads to improving anabolism. And under the first method refers to a 24-hour break between meals, for example, from breakfast to lunch, which is a potent stimulator of the release of Growth Hormone, whose level remains elevated for some time after the start of supply. As a result of the day following the day of fasting, a small weight loss is fully compensated, and the next day there is supercompensation - number of structural proteins of the body exceeds that number to starvation. A similar method is used with skiers in order to maximize the storage of glycogen before important competitions, which we will discuss in the chapter "Sports Nutrition" in the next issue. But experts agree that you should not just take a chance and apply these methods to the important starts. First we need to understand how the body reacts to them.

Competition Period

The most responsible for the skier's time - is the period from January to March, called the competition period, when the training schedule is extremely full of important competitions and by an athlete requires the maximum result. This stage is fully shows whether you have prepared in the summer sled or not ... The middle of winter and the beginning of spring - a time when the number of used pharmaceuticals even more reduced. Of these groups in pharmacological ensuring competition period only saved Adaptogens, energy products and intermediates (Mildronate, ATP Ðhosphaden, Fosfobion, Inosine, Riboxin, Neoton, Creatine Phosphate) and minimal doses of vitamins (must be present vitamins E, C, B1). Vitamin E is found in muscle and fat. Its function is not well understood. It is known that it enhances the activity of vitamins A and C, preventing their oxidation. The most significant of its function is an anti-oxidant action. A significant part of the athletes, obviously consume large doses of this vitamin on the basis of the assumption that it has a positive effect on muscle activity due to its interaction with oxygen transport and energy supply. However, according to experts, long-term use of vitamin E is not conducive to this. Complex application of these pharmaceutical drugs can accelerate the recovery processes between starts, provides high contractile ability of muscle fibers, it helps to stimulate the processes of cellular respiration.

For purely competitive pharmacological agents are Actoprotectors - drugs, not so long ago fallen into the arsenal of sports pharmacology, but has been widely recognized: Sodium Succinate, Limontar (a derivative of Citric and Succinic Acids), Bromentane, Ladasten. Actoprotectors prevent the emergence of disorders of metabolism (metabolism) in the body at the time of exercise, stimulate cellular respiration and promote energy-enhanced synthesis of compounds (ATP, phosphocreatine). Under the action Actoprotectors increased glycogen content in muscles, liver and heart. Tanacan is an actoprotector, and it operates in many ways, allowing you to identify themselves as Adaptogens and antioxidants and nootropics too. If its application is marked by performance improvement, reducing irritability and nervousness home, increase concentration, normalization of sleep.

Neoton (phosphocreatine drug) Adenylic Acid and Ðhosphadenum, Cardiomone, Fosfostimol (ATP fragment stimulates the synthesis of nucleotides, enhances Redox processes, serves as an energy supplier) are versatile sources of energy, and therefore most effective in competitive practices and on the stages of the training process, where It aims at developing a high-speed endurance, and there is a significant proportion of the work in the anaerobic mode. ATP contained in the muscle enough for the operation of no more than 0.5 seconds, so when the muscle uses energy other caged high-energy phosphates (phosphagens). These are just above drugs. Phosphocreatine, as a source of energy for muscle contraction, is leading the work in the anaerobic zone alactic power when its reserves in the muscle cell limit the duration and intensity of work.

In the competitive period are particularly relevant antihypoxants - a class of compounds that increase the body's resistance to lack of oxygen. From this group of drugs attracts the attention of an exceptionally strong antihypoxants Sodium Oxybutirate and Mildronate. It activates the anoxic oxidation of energy substrates and reduces the body's need for oxygen, which is particularly important during the race. In addition, Sodium Oxybutirate itself capable cleaved to form the energy stored in the form of ATP. Thanks to all of its properties, it is currently the most effective means for the development of endurance (by the way, in addition to this, it has a strong adaptive and anti-stress effect, which allows it to carry medicines designed to help with CNS overvoltage). In antihypoxants group are also included: cytochrome C, Actovegin, Olyphenum (Hypoxenum).

The question of support for the immune system is the most important in this period, since the entry into peak shape athlete immunity suffers most. Significantly increases the risk of acute respiratory infection and flu. Because drugs can be identified Echinacea (Immunal), vitamin C, honey, pollen, mummy, Imunofan, Beres Drops Plus and others. If you are still sick, the pharmacies you can find multitudes of various drugs, "good" flu and colds are the most common diseases worldwide. In addition to proper nutrition can not only speed up recovery, but also to prevent the development of complications. During the period of high temperature, the decrease in the enzymatic activity of the gastrointestinal tract, and therefore, in the first days of the disease it is recommended unloading diet. Later shows full, rich in vitamins, macro- and microelements nutrition. Recommended mainly dairy and vegetable diet. Copious warm drink - warm milk with an alkaline mineral water. To reduce the toxicity is necessary to use large amounts of fluids (1500-1700 ml) and a sufficient amount of vitamins, especially C, P, A and carotene. Vitamins C and E strengthen the walls of blood vessels, so it is useful saturation diet foods rich and the other vitamins (eg, rose hips, black currants, cranberries, cranberry, chokeberry, lemons, etc.). Oh, and do not forget the folk remedies! For example, all known for its antibacterial properties and more garlic helps maintain the health of the circulatory system and can lower blood cholesterol levels.

Regular exercise leads to increased risk of iron deficiency in the body of an athlete and the development of so-called "athlete's anemia." The hemoglobin concentration of an athlete than 140 g / l is regarded as a sign of clinical anemia. Up to a certain stage of iron deficiency is compensated for by the body, but in terms of "peak" loads of training and competition, this compensation becomes insufficient, in connection with which there is a rapid reduction in the special performance. An example of a course of saturation: Aktiferrin (1 capsule daily - 20 days.) Ferrîplåõ (2 capsules 2 p per day - 25 days..), Fenules (1 capsule 2 p per day - 25 days..), Totem and veal beef liver.

In conclusion I would say that the main means of improving athletic performance training will remain forever. A large number of pharmacological agents at low loads and irresponsible attitude to physical pursuits will never lead to a higher purpose. This chapter is written for people who are training hard and need the support of the body. We must remember that drugs used athlete, always come together to interact, which can predict an ordinary skier, so assign them in any case can only qualified sports doctor. If you use a large amount of drugs - it does not mean that their action will go to you solely for the benefit. In more than five items of their effect is unpredictable, so please be careful and always consult with a sports doctor!


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Potent antidepressant

18 Oct 2016

Samyr is a potent antidepressant which has no unwanted side effects.

Samyr is a potent antidepressant which has no unwanted side effects, as compared to other antidepressants. It works to improve the impact of mood-boosting neurotransmitters such as serotonin and dopamine.

Is natural energy, increase chemical reaction, which became one of the most popular for the treatment of depression in recent history.
S-adenosyl-L-methionine plays a significant role in the energy of chemical processes in the body. This is particularly important in the production of adenosine triphosphate (ATP), which is one of the most fundamental, "life energy" of biomolecules.

Phenibut is also potent antidepressant, it has mild effect!


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Vitamin B12 (Vitaminum B12)

18 Oct 2016

Vitamin B12 refers to the group of water soluble vitamins.

Cyanocobalamin has a high biological activity. This preparation is necessary for normal hematopoiesis (promotes the maturation of red blood cells). Participation in transmethylation processes, hydrogen transfer, methionine synthesis, nucleic acids, choline, creatine. It contributes to the accumulation in erythrocytes of compounds containing sulfhydryl groups. It has a beneficial effect on the function of the liver and nervous system. Activation of blood coagulation in high doses causes increased activity of thromboplastin and prothrombin.
Vitamin B 12 (cyanocobalamin) is a cofactor for methionine synthase, which catalyzes the conversion of tetrahydrofolate methyltetrahydrofolate to homocysteine to methionine and subsequently converted to S-adenosylmethionine (SAM). Lack tetrahydrofolate required for DNA synthesis, leads to inadequate maturation of erythrocytes, which manifests as megaloblastic anemia, while reducing production SAM units during the synthesis of phosphatidylcholine, an important component of myelin sheaths.


Lack of vitamin B12 as a cofactor of mitochondrial mutase, interferes with the normal formation of myelin sheaths, as it is the absence or violation of the biosynthesis of fatty acids, which are the structural part of the myelin sheath.


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Acyzol is an alternative to Hypoxen?

18 Oct 2016

Hardly anyone of the gentlemen climbers, rushing to the shining peaks, did not experience the "charms" of altitude sickness, crossing the border of hypoxia.

The boundary of this (according to various sources), is depending on the mountain, located at altitudes of 3500-4500 meters above sea level.

Probably everyone remembers headache, irritability, apathy, decreased performance, and sometimes nausea and vomiting. In general, means of prevention of this condition old as climbing, - the right acclimatization schedule and increase resistance of the organism by training aimed at developing general endurance. In addition, you can use antihypoxants - drugs that increase resistance to hypoxia target organs: the brain and myocardium. For example, the domestic development called hypoxia. It creates a miracle remedy, primarily for combat divers, Air Force pilots, professional athletes as increase efficiency, resistance to hypoxia and reduces the recovery period after exercise. The mechanism of action - improving the utilization of oxygen to tissues. Someone may have used this drug. Research is carried out mainly on athletes engaged in cyclic sports.

Acyzol and Hypoxen

And now the market goes Acyzol is development of Soviet scientists as an antidote for poisoning by carbon monoxide. Acyzol has, on assurances of manufacturers, a number of other advantages and what is interesting to us is antihypoxant. I decided to try for myself. I take on the ascent of Kilimanjaro (5896 m). Standard program - climbing on the fifth day of the intersection of the gate to the national park. Three years ago, up to the same and on the same route, then I used Hypoxen. Any medical controls were not even oximeter unsold, some subjective feeling: hard, head sick, do not run. 12:00 go. At this time I tried Acyzol was much easier. I went for 6 hours. And it seems clear in my head. Pulse again not considered. Oxygen saturation, too. Next Time I will try to use Mildronate.


Someone from the Qatar - just purchased the goods:
Azopt eye drops 1% 5ml