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Trusopt eye drops - is a drug based on dorzolamide hydrochloride, reducing the increased intraocular pressure associated with glaucoma or intraocular hypertension. The drug has few contraindications and good tolerability.
Trusopt eye drops - antiglaucoma preparation.
The composition of the drug Trusopt includes an inhibitor of carbonic anhydrase II - dorzolamide hydrochloride. Inhibition of carbonic anhydrase in the ciliary body of the eyeball reduces the production of intraocular fluid, presumably due to a slowing down of the synthesis of bicarbonate ions with their subsequent reduction to sodium and elimination of the liquid. As a result, the intraocular pressure decreases.
With prolonged use, dorzolamide selectively accumulates in erythrocytes as a result of selective binding to carbonic anhydrase II, while the concentration of free dorzolamide in plasma remains extremely low.
Dorzolamide forms the only metabolite, N-desethyl-dorzolamide, which suppresses to a lesser extent than dorzolamide, the enzyme carbonic anhydrase II, and also the enzyme carbonic anhydrase I. The metabolite accumulates in red blood cells, mainly binding to carbonic anhydrase I.
Dorzolamide moderately binds to plasma proteins (about 33%).
Dorzolamide and its metabolite are excreted mainly unchanged through the kidneys. After the end of treatment, dorzolamide is washed out of the erythrocytes unevenly, i.e., very intensively at the beginning, which leads to a rapid and significant decrease in concentration, followed by a slow phase of washout with T1 / 2 for about 4 months.
Trusopt is prescribed to reduce elevated intraocular pressure, associated and not associated with glaucoma. Trusopt is shown to patients:
The use of Trusopt was not studied in patients with severe hepatic impairment, and therefore, use the drug in this category of patients with caution.
Patients who wear contact lenses should consult a doctor before using Trusopt, since the preservative included in the product may cause eye irritation. The drug Trusopt contains as a preservative benzalkonium chloride, which can be adsorbed by contact lenses. Before using the drug, the lens must be removed; Do not wear the lens before 15 minutes after instillation. Benzalkonium chloride is capable of discoloring soft eye lenses.
Impact on the ability to drive vehicles and manage mechanisms
During the treatment with the drug Trusopt it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.
With Trusopt, the usual dose is 1 drop to the affected eye (or both eyes) in the morning, afternoon and evening.
When replacing any antiglaucoma drug with Trusopt, treatment with Trusopt should be started the day after the previous drug was discontinued.
When using Trusopt with other eye drops at the same time, they should be instilled with an interval of at least 10 minutes.
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