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Instructions

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Instruction for use: Pirlindole

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Latin name of substance Pirlindole

Pirlindolum (genus. Pirlindoli)

Chemical name

2,3,3 alfa, 4,5,6-Hexahydro-8-methyl-1H-pyrazino [3,2,1-jk] carbazole

Gross formula

C15H18N2

Pharmacological group:

Antidepressant

The nosological classification (ICD-10)

F03 Dementia, unspecified: Degenerative dementia; Dementia; Dementia presenilnaya; Dementia senile; Primary degenerative dementia; Senile dementia; Senile dementia of the Alzheimer's type; Senile dementia; Syndromes of dementia; Dementia; Mixed Dementia; Mixed forms of dementia; Senile dementia; Senile Dementia

F06 Other mental disorders due to brain damage or dysfunction or somatic disease: Somatogenic depression; Somatogenic psychosis

F06.3 Organic mood disorders [affective]: Secondary affective symptoms; Organic depression; Affective disorders; Depressed mood with elements of anxiety

F10.3 Abstinence: Alcohol withdrawal syndrome; Abstinence syndrome; Abstinence syndrome with alcoholism; Abstinence; Alcohol abstinence; Alcohol withdrawal status; Alcohol abstinence syndrome; Postabstinctive disorder; Postabstinent condition; Hangover syndrome; Abstinence syndrome; Alcohol withdrawal syndrome; Abstinence condition

F20 Schizophrenia: Schizophrenic Conditions; An exacerbation of schizophrenia; Schizophrenia; Chronic schizophrenia; Dementia praecox; Bleuler's disease; Psychotic discordant; Dementia early; The febrile form of schizophrenia; Chronic schizophrenic disorder; Psychosis of the schizophrenic type; Acute form of schizophrenia; Acute schizophrenic disorder; Cerebral Organic Insufficiency in Schizophrenia; Acute attack of schizophrenia; Schizophrenic psychosis; Acute schizophrenia; Sluggish schizophrenia; Sluggish schizophrenia with apathoabulic disorders; Acute stage of schizophrenia with agitation

F32 Depressive episode: Adynamic subdepression; Astheno-adynamic subdepressive states; Asthenoadressive disorder; Astheno-depressive disorder; Asthenodepressive state; Astheno-depressive state; Major Depressive Disorder; Vyaloapatichesky depression with retardation; Double Depression; Depressive pseudodement; Depressive illness; Depressive mood disorder; Depressive disorder; Depressive mood disorder; Depressive state; Depressive disorders; Depressive syndrome; Depressive syndrome larviated; Depressive syndrome in psychoses; Depressed masks; Depression; Depression Depletion; Depression with the phenomena of inhibition within the framework of cyclothymia; Depression is smiling; Involutional depression; Involutionary melancholy; Involutional depression; Manic-depressive disorder; Masked Depression; Melancholic Attack; Neurotic depression; Neurotic depression; Shallow Depression; Organic depression; Organic depressive syndrome; Simple depression; Simple melancholic syndrome; Psychogenic depression; Reactive depression; Reactive depression with moderate psychopathological symptoms; Reactive depressive states; Reactive depression; Recurrent depression; Seasonal depressive syndrome; Severostatic depression; Senile Depression; Symptomatic Depression; Somatogenic depression; Cyclotymic depression; Exogenous depression; Endogenous depression; Endogenous Depressive Conditions; Endogenous Depression; Endogenous depressive syndrome

F34.0 Cyclothemia

F34.1 Dysthymia: Dysthymic state within the framework of psychopathic disorders in children and adolescents

F43.0 Acute stress reaction

F43.1 Post-traumatic stress disorder: Combat fatigue; Catastrophe Syndrome; The survivor's syndrome; Traumatic isolation; Traumatic neurosis; Traumatic syndrome; Post-Traumatic Stress Disorder

F43.2 Adverse Reactions Disorder: Mental Adjustment Disorder

F44 Dissociative [conversion] disorders: Psychogenic psychosis; Conversion disorder; Dissociative phenomena; Pseudodemency; Conversion symptoms

F45 Somatoform disorders: Psychosomatic disorder; Psychosomatic disorders; Psychosomatic diseases; The state of excitement in somatic diseases; Functional psychosomatic disorders of the cardiovascular system

F48.0 Neurasthenia: Asthenic form of neurasthenia; Asthenoneurotic disorder; Astheno-neurotic state; Flu of young workaholics; Influenza yuppie; Neurasthenic disorders; Neurasthenic conditions; Neurasthenic syndrome

F50.0 Anorexia nervosa: Anorexia nervosa syndrome; Anorexia nervosa; Anorexia nervously-psychical; Cachexia nervy; Psychogenic anorexia

F79 Mental retardation, unspecified: Mental retardation; Infantilism mental; Violation of mental activity; Oligophrenia; Lag behind mental development; Slowed development of intellectual abilities in children and adolescents; Delayed mental development in children; Maloumia; Oligopsihia; Mental failure; Impaired mental function; Lag behind in mental development; Lack of intellectual development in children; Lack of mental development in children; Mental retardation; Lack of mental development in children; Mental retardation

G30 Alzheimer's Disease: Alzheimer's Disease

CAS code

60762-57-4

Characteristics of the substance Pirlindole

White with a yellowish or greenish tinge crystalline powder. Almost nerastvorim in the water.

Pharmacology

Pharmacological action - antidepressant.

Combines a timoleptic effect with a regulating effect on the central nervous system (activating effect on patients with apathetic and anergic depression and sedative - in agitated states). It shows nootropic properties and improves cognitive (cognitive) functions. Normalizes the exchange of neurotransmitter monoamines in the central nervous system. Reversibly inhibits MAO (especially MAO type A), blocks deamination of serotonin, to a lesser extent - norepinephrine and slightly - tyramine. Stimulates adrenergic (alleviates depression caused by reserpine, and potentiates the effects of phenamine and the predecessor of norepinephrine - L-dopa) and serotonergic (enhances the action of the precursor of serotonin - 5-hydroxytryptophan) structure. Partially inhibits the reuptake of serotonin.

Quickly absorbed after ingestion, easily passes through the histohematological barriers, including the BBB; creates high concentrations in the brain.

Application of substance Pirlindole

Manic-depressive psychosis, schizophrenia with affective disorders and involuntary psychosis, which occurs with depression, depression, incl. with psychomotor retardation and asthenic disorders, accompanied by anxiety-depressive and anxious-delirious components, anesthetic, hypochondriac and neurosis-like symptoms, senile, involutional depression, depressive and anxious-depressive states in patients with alcoholism, especially during the period of abstinence.

Contraindications

Acute inflammatory diseases of the liver and hematopoietic system, pregnancy and lactation (during treatment is excluded), infant age, preceding (1-2 weeks) administration of MAO inhibitors.

Side effects of substance Pirlindole

Dry mouth, sweating, tremor, tachycardia, nausea, dizziness.

Interaction

Incompatible with MAO inhibitors, incl. with preparations with similar activity (furazolidone, procarbazine, selegiline, etc.). Can increase the response to adrenaline and other sympathomimetics.

Overdose

It is manifested by an increase in the severity of side effects.

Treatment: gastric lavage, reception of activated charcoal, symptomatic therapy.

Routes of administration

Inside.

Precautions for the substance Pirlindole

Work that requires increased mental and physical responses (management of complex potentially dangerous and transport mechanisms) should be avoided.

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