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Instruction for use: Estriol (Estriolum)

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Pharmacological group of substance Estradiol

Estrogens, gestagens; their homologues and antagonists

Nosological classification (ICD-10)

L29.3 Anogenital pruritus, unspecified

Itching in the genital and anus, Anal itching, Anogenital itching, Genital itching, Anogenital itching, Itching of the anorectal region, Itching of the vulva, Itching of the genitals, Perianal dermatitis

N95.1 menopausal and menopausal status of women

Atrophy of the mucosa of the lower genital tract, caused by estrogen deficiency; Vaginal dryness; Autonomic dysfunction in women; gipoestrogeniya state; Deficiency of estrogen in menopausal women; Degenerative changes of the mucous membrane in the menopause; Natural menopause; an intact uterus; climacteric; Menopause women; Menopause in women; menopausal depression; Climacteric ovarian dysfunction; Menopause; Climacteric neurosis; Menopause; Menopausal symptoms complicated psychovegetative; Climacteric syndrome; Climacteric vegetative disorders; Climacteric psychosomatic disorder; menopausal disorders; Menopausal disorders in women; menopausal condition; Climacteric vascular disorders; Menopause; Menopausal vasomotor symptoms; menopausal period; Lack of estrogen; Feeling the heat; Pathological menopause; perimenopause; menopause; postmenopausal; Premature menopause; premenopauznom period; tides; hot flashes; flushing in the Meno and postmenopausal; Hot flashes / hot flashes in menopause; Heart attack during menopause; Early menopause in women; Disorders of menopause; climacteric syndrome; Vascular complications of menopause; Physiological menopause; Estrogendefitsitnye state; premature Menopause

N95.2 Postmenopausal atrophic vaginitis

Atrofic vulvovaginitis, Vulvovaginitis estrogen-deficient, Atrophied vagina, Atrophic changes in the organs of the urogenital system in women, Atrophy of the mucous membrane of the lower sections of the genito-urinary tract, caused by estrogen deficiency Atrophy of the mucous membranes of the urino-genital organs, Burning and dryness of the vagina, Violation of the composition of the vaginal secretion in menopause, Dryness of the mucous membrane of the vagina, Degenerative disorders of the female sexual sphere, Atrophic vaginitis, Atrophic vulvovaginitis, Atrophy of lower urinary tract, Atrophy of urogenital organs, Dryness of the mucous membranes of the urino-genital organs, Dryness of the mucous membranes of the urogenital tract, Dryness of the vagina

Z100 * CLASS XXII Surgical practice

Abdominal surgery, adenomectomy, Amputation, Coronary angioplasty, Angioplasty of the carotid arteries, Antiseptic skin treatment for wounds, Antiseptic Hand, Appendectomy, atherectomy, Balloon coronary angioplasty, Vaginal hysterectomy, The coronary bypass, Interventions in the vagina and cervix, Interventions on the bladder, Intervention in the mouth, Restoration and reconstructive surgery, Hand hygiene of medical personnel, Gynecologic surgery, Gynecological intervention, Gynecological surgery, Hypovolemic shock during operations, Disinfection of purulent wounds, Disinfection of wounds edges, Diagnostic intervention, Diagnostic procedures, Cervical Diathermocoagulation, Long-surgery, Replacing the fistula catheters, Infection in orthopedic surgery, Artificial heart valve, cystectomy, Short-term outpatient surgery, Short-term operation, Short surgical procedures, Krikotireotomiya, Blood loss during surgery, Bleeding during surgery and in the postoperative period, Kuldotsentez, laser photocoagulation, laser coagulation, retinal laser coagulation, Laparoscopy, Laparoscopy in Gynecology, CSF fistula, Small gynecological operations, Small surgical procedures, Mastectomy and subsequent plastic, mediastinotomy, Microsurgical operations on the ear, Mukogingivalnye operation, suturing, Minor surgery, neurosurgical operation, Immobilization of the eyeball in ophthalmic surgery, testectomy, pancreatectomy, Perikardektomiya, The period of rehabilitation after surgery, The period of, convalescence after surgery, Percutaneous transluminal coronary angioplasty, Pleural thoracentesis, Pneumonia postoperative and posttraumatic, Preparation for surgical procedures, Preparation for surgery, Preparation of the surgeon's hands before surgery, Preparation of the colon for surgical procedures, Postoperative aspiration pneumonia in neurosurgical and thoracic surgery, Postoperative nausea, Postoperative bleeding, postoperative granuloma, postoperative shock, The early postoperative period, myocardial revascularization, Radiectomy, gastric Resection, bowel resection, uterine Resection, liver Resection, enterectomy, Resection of part of the stomach, Reocclusion of the operated vessel, Bonding tissues during surgical procedures, Removal of sutures, Condition after eye surgery, Condition after surgery, Condition after surgery in the nasal cavity, Condition after gastrectomy, Status after resection of the small intestine, Condition after tonsillectomy, Condition after removal of the duodenum, Condition after phlebectomy, Vascular surgery, Splenectomy, Sterilization of surgical instruments, Sterilization of surgical instruments, sternotomy, Dental surgery, Dental intervention in periodontal tissues, strumectomy, Tonsillectomy, Thoracic surgery, total gastrectomy, Transdermal intravascular coronary angioplasty, Transurethral resection, Turbinektomiya, Removal of a tooth, cataract surgery, Removal of cysts, tonsillectomy, Removal of fibroids, Removing the mobile primary teeth, Removing polyps, Removing broken tooth, Removal of the uterus body, Removal of sutures, Urethrotomy, Fistula likvoroprovodyaschih ways, Frontoetmoidogaymorotomiya, Surgical infection, Surgical treatment of chronic limb ulcersm, Surgery, The surgery in the anal area, The surgery on the colon, Surgical practice, The surgical procedure, Surgical interventions, Surgery on the gastrointestinal tract, Surgical procedures on the urinary tract, Surgical procedures on the urinary system, Surgical intervention of the genitourinary system, Surgical procedures on the heart, Surgical manipulation, surgery, Surgery on the veins, Surgical intervention, Vascular surgery, Surgical treatment of thrombosis, cholecystectomy, Partial gastric resection, transabdominal hysterectomy, Percutaneous transluminal coronary angioplasty, Percutaneous transluminal angioplasty, Coronary artery bypass, tooth Extirpation, Extirpation of milk teeth, pulpectomy, pulsative cardiopulmonary bypass, tooth Extraction, teeth Extraction, cataract extraction, Electrocoagulation, endourological intervention, episiotomy, Etmoidotomiya, Complications after tooth extraction

Code CAS 50-27-1


The pharmacological action is estrogenic.

Promotes the restoration of normal vaginal epithelium with its atrophic changes in the premenopausal and postmenopausal periods, normalizes the pH of the vaginal environment, the microflora of the vagina, increases the resistance of its epithelium to infectious and inflammatory processes. Slightly increases the volume of plasma, reduces the cholesterol in the blood, increases the circulation time of corticosteroids.

When applied orally and locally rapidly and almost completely absorbed, Cmax is achieved 1 hour after ingestion and 1-2 hours after intravaginal application (Cmax value after intravaginal application above). In the blood it binds to albumins (90%). It is excreted mainly by the kidneys in conjugated form, 2% is excreted through the intestine in unchanged form; excretion of metabolites with urine begins a few hours after the appointment and lasts up to 18 hours.

Application of Estriol

Atrophy of the mucous membrane of the lower urinary tract due to estrogen deficiency, pre- and postoperative therapy in postmenopausal women with surgical interventions with vaginal access, climacteric syndrome (hot flushes and increased sweating at night, etc.); infertility caused by a cervical factor; dyspareunia, dryness of the vagina, itching, frequent urination, mild incontinence; Diagnosis with unclear results of a smear from the vagina on cytology.


Hypersensitivity, thrombosis (venous and arterial), embolism, marked violations of the liver, hormone-dependent tumors of the uterus or mammary glands, uterine bleeding of unclear etiology, otosclerosis, severe itching or cholestatic jaundice, as well as intensifying their manifestations during anterior pregnancy or steroid preparations, pregnancy.

pregnancy and lactation

Contraindicated in pregnancy.

Side effects of Estriol

Tension or pain in the mammary glands, fluid retention, nausea, hypersecretion of cervical mucus, arterial hypertension, gastrocnemius muscle cramps, headache, visual impairment, pigmentation spots on the skin; local irritation or itching (cream).


Symptoms: nausea, vomiting, spotting from the vagina.

Treatment: symptomatic therapy.

Routes of administration

Inside, intravaginally.

Precautions for Estriol

Caution is prescribed for thromboembolic episodes in history, heart failure, renal dysfunction, arterial hypertension, epilepsy, migraine, severe liver disease, endometriosis, fibrocystic mastopathy, porphyria, hyperlipoproteinemia.

When taking estriol, an annual medical examination is recommended.

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