Instruction for use: Artamin

Dosage form: Capsules

Active substance: Penicillaminum

ATX

M01CC01 Penicillamine

Pharmacological groups:

Immunodepressants

Detoxifying agents, including antidotes

The nosological classification (ICD-10)

E72 Other disorders of amino acid metabolism: Amino acid deficiency; Amino acid deficiency; Aminoaciduria; Deficiency of glutamine; Valynemia; Hereditary anomalies of amino acid metabolism

K73 Chronic hepatitis, not elsewhere classified: Inflammatory liver disease; Hepatitis autoimmune; Hepatitis chronic; Infection of the liver; Chronic hepatitis with signs of cholestasis; Chronic reactive hepatitis; Chronic persistent hepatitis; Chronic infectious hepatitis; Chronic active hepatitis; Chronic inflammatory liver disease; Autoimmune Hepatitis; Chronic hepatitis is aggressive

K74 Fibrosis and cirrhosis of the liver: Edematous-ascitic syndrome in cirrhosis; Inflammatory liver disease; Pretsirroticheskoe state; Cystic fibrosis of the liver; Cirrhotic and pretsirroticheskoe state; Cirrhosis portal hypertension c; Cirrhosis of the liver with signs of portal hypertension; Cirrhosis of the liver with portal hypertension and edema-ascites syndrome; Cirrhosis of the liver with portal hypertension; Liver cirrhosis with ascites and edema; Liver cirrhosis with ascites; cirrhotic ascites

M05 Seropositive rheumatoid arthritis: Seropositive rheumatoid arthritis

M34 Systemic sclerosis: scleroderma; scleroderma is a generalized; diffuse scleroderma; scleroderma universal; Progressive systemic sclerosis; Buschke's disease; scleredema; Sclerema aponeurotic benign

T56.0 Toxic effect of lead and its compounds: Lead toxicity; Toxic effect of lead and its compounds; Lead poisoning; Poisoning with sleeping pills and narcotic drugs; Chronic lead poisoning; Lead colic; Plumbism; Acute lead encephalopathy; Lead poisoning

T56.1 Toxic effects of mercury and its compounds: Mercury intoxication; Chronic mercury poisoning

T56.4 Toxic effect of copper and its compounds: copper intoxication

T56.5 Toxic effects of zinc and its compounds: Zinc poisoning; Intoxication with zinc; Zinc compounds poisoning; Foundry fever; Zinc Fever

T56.8 Toxic effects of other metals: Cesium poisoning; Poisoning with cerium; Magnesium and its compounds; Cobalt poisoning; The poisoning of gold compounds; Chronic nickel intoxication; Poisoning with magnesium salts; Poisoning by plutonium

Composition and release form

1 capsule contains penicillamine 150 or 250 mg; In a cardboard box 5 blisters for 10 pcs.

Pharmachologic effect

Mode of action - Immunosuppressive, complexing.

It is capable of chelating. It suppresses T-helper function of lymphocytes, inhibits neutrophil chemotaxis and lysosomal enzyme release, enhances macrophage functions, reduces the level of insoluble collagen.

Pharmacodynamics

Forms chelate complexes with ions of copper, mercury, lead, iron, arsenic, calcium, zinc, cobalt, gold. When interacting with cysteine, a disulfide appears, which has a much higher solubility than cysteine.

Indication of the drug Artamin

Poisoning by heavy metals (copper, gold, lead, mercury, cobalt, zinc), Wilson-Konovalov's disease, rheumatoid arthritis (including juvenile), primary biliary cirrhosis, chronic hepatitis, scleroderma, cystinuria, cystinosis.

Contraindications

Hypersensitivity, violation of hemopoiesis, agranulocytosis, myasthenia gravis, nephropathy, pregnancy.

Side effects

Dyspeptic disorders, hematopoietic depression, cholestatic syndrome, peripheral neuropathy, myasthenia gravis, polymyositis, dermatomyositis, fever, arthralgia, lymphadenitis, alopecia, allergic reactions.

Interaction

Incompatible with antibiotics.

Dosing and Administration

Inside, on an empty stomach (do not eat for 1.5 hours before and after taking). With rheumatoid arthritis, hepatitis, scleroderma: 1-4 weeks - 1 caps. (150 mg) per day (up to 250 mg); 5-8 weeks - 1 caps. (250 mg) per day (up to 450 mg); 9-13 weeks - 1 caps. (150 mg) 2 times a day (up to 600 mg); Increase the dose by 50-150 mg per day with 4-12 weeks intervals - up to 750 mg per day.

Juvenile rheumatoid arthritis: with a body weight of less than 20 kg - 1 caps. (50 mg) per day, over 20 kg - 1 (50 mg) 2 times a day; Increase the dose by 50 mg with 2-4 weeks intervals to 15-20 mg / kg or 600 mg per day. Wilson-Konovalov's disease: adults - a gradual increase in dosage from 250 mg to 2 grams per day, children - from 150 to 750 mg per day. Cystinuria - 1000 mg / m2 of the body surface. Poisoning - 0,9-1,8 g per day or 2-4 caps. (150 mg) 3 times.

Precautionary measures

It is necessary to constantly monitor blood, urine (general analysis, alkaline phosphatase, transaminases).

Storage conditions of the drug Artamin

In a dry place, at room temperature.

Keep out of the reach of children.

Shelf life of the drug Artamin

5 years.

Do not use after the expiry date printed on the package.