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Instruction for use: Apranax

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Active substance Naproxen

ATX code M01AE02 Naproxen

Pharmacological group

NSAIDs - Propionic acid derivatives

Pharmacological group

NSAIDs - Propionic acid derivatives

Nosological classification (ICD-10)

M00-M25 Arthropathy

M05 Seropositive rheumatoid arthritis

Rheumatoid arthritis seropositive

M10 Gout

Exacerbation of gout, Acute articular attack with gout, Acute gouty attack, Gouty attack, Recurrent gout attacks, Chronic gout

M15-M19 Osteoarthritis

M45 Ankylosing spondylitis

Ankylosing spondylarthrosis, Marie-Strumpel disease, Ankylosing spondylitis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Bechterew's disease, Ankylosing spondylitis, Diseases of the spinal column, Rheumatic spondylitis, Bechterew-Marie-Strumpel disease

M71 Other bursopathies

Bursitis, Bursopathy, Diseases of soft tissues, Osteoarthritis in musculo-articular diseases, Inflammatory disease of soft tissues, Subacute bursitis

M77.9 Other unspecified

Capsule, Periarthritis, Tendonitis, Tendopathy, Periarthropathy

M79.0 Other unspecified rheumatism

Degenerative rheumatic disease, Degenerative and rheumatic diseases of the tendons, Degenerative rheumatic diseases, Localized forms of rheumatism of soft tissues, Rheumatism, Rheumatism with a pronounced allergic component, Rheumatism of the articular and extraarticular, Rheumatic attack, Rheumatic complaints, Rheumatic diseases, Rheumatic disease of the spine, Relapses of rheumatism, Articular and extra-articular rheumatism, Articular and muscular rheumatism, Articular rheumatism, Articular syndrome with rheumatism, Chronic rheumatic pain, Chronic articular rheumatism, Rheumatoid diseases, Rheumatic diseases of the intervertebral disc

N94.6 Dysmenorrhea Unspecified

Pain during menstruation, Functional disorders of the menstrual cycle, Menstrual cramps, Emmeniopathy, Pain during menstruation, Painful menstrual irregularities, algomenorrhea, algomenoreya, Pain smooth muscle spasm, Pain spasm of smooth muscles (renal and biliary colic, intestinal spasms, dysmenorrhea), Pain spasm of smooth muscles of internal organs (kidney and biliary colic, intestinal spasms, dysmenorrhea), Disalgomenoreya, dysmenorrhea, Dysmenorrhea (essential) (Exfoliative), menstrual disorder, menstruation painful, metrorrhagia, Violation of the menstrual cycle, Menstrual irregularities, Prolaktinzavisimoe menstrual disorders, Prolaktinzavisimoe menstrual dysfunction, Pain spasm of smooth muscles of internal organs, Spasmodic dysmenorrhea, Primary disalgomenoreya

R52.2 Other constant pain

Pain syndrome, rheumatic origin, Pain at vertebral lesions, Pain in the chamber, Pain for burns, Pain syndrome weak or moderate, Perioperative pain,Moderate to severe pain, Moderately or weakly expressed pain syndrome, Moderate to severe pain, Ear pain of otitis, Neuropathic pain, neuropathic pain

Composition and form of release

1 tablet contains naproxen sodium 550 mg; in a blister 10 pcs., in the package 1 and 5 blisters.

pharmachologic effect

Pharmacological action - anti-inflammatory, antipyretic, analgesic.

Naproxen inhibits the synthesis of PG (prostaglandins).


Acute and chronic pain in rheumatic inflammatory and degenerative diseases (rheumatoid arthritis, arthrosis, ankylosing spondylitis), extraarticular rheumatism (bursitis, tendonitis, lumbago, etc.), dysmenorrhea, surgical interventions and traumatic stroke, gout.


Hypersensitivity, allergy to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs, stomach and duodenal ulcer in the phase of exacerbation, pregnancy (especially in the III trimester), lactation, age (up to 1 year).

Side effects

Gastrointestinal disorders (nausea, vomiting, unpleasant sensations in epigastrium, feeling of stomach overflow, diarrhea), headache, dizziness, loss of attention, disturbance of the thinking process, insomnia, tinnitus, hearing loss, erosive ulcerative lesions (including ulcerative stomatitis ), bleeding and perforation of the gastrointestinal tract, colitis, jaundice, hepatitis, eosinophilic pneumonia, nephropathy, hematuria, thrombocytopenia, granulocytopenia, aplastic and hemolytic anemia, erythema multiforme exudative, vasculitis, porphyrodermatosis, al petsiya, photosensitivity, epidermal necrolysis, and cutaneous anaphylactoid reactions, angioedema.


Reduces the hypotensive effect of beta-adrenoblockers (propranolol), natriuretic effect of furosemide, inhibits renal Cl lithium, slows the excretion of methotrexate in the urine. Probenecid raises the level in the blood and increases the half-life.

Dosing and Administration

Inside, not liquid, with a small amount of liquid. At the beginning of treatment and with acute exacerbation, 1100 mg / day (maximum 1375 mg) in 1 (evening) or 2 divided doses (with an interval of 12 hours) are prescribed. With dysmenorrhea, the initial dose is 550 mg, then - at 275 mg every 6-8 hours for 3-4 days; with gout, the initial dose is 825 mg, then - 275 mg every 8 hours (until the end of the attack). Children older than 1 year with juvenile rheumatoid arthritis - 11 mg / kg / day are appointed in 2 divided doses (with an interval of 12 hours).

Storage conditions

In the dark place.

Keep out of the reach of children.

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