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Katadolon Forte (Flupirtine, Flupirtinum) - non-narcotic analgesic agent. Flupirtine (Flupirtinum) is the prototype of a new class of substances SNEPCO ( «Selective Neuronal Potassium Channel Opener» - «selective neuronal potassium channel activators").
It refers to non-opioid analgesics central action without causing dependence and addiction.
Flupirtine has analgesic, muscle relaxant and neuroprotective effect based on indirect antagonism against NMDA (N-methyl-D-aspartate) - receptor to activate downstream mechanisms in pain modulation and GABAergic processes.
At therapeutic concentrations, flupirtine does not bind to alpha 1 -, alfa2-, 5NT1, 5NT2-, dopamine, benzodiazepine, opiate, central muskarinergicheskimi or nikotinergicheskimi receptors.
For the treatment of acute and chronic pain caused by:
With care prescribe a drug to patients with impaired liver and / or kidney disease, patients older than 65 years.
In patients with reduced kidney function or liver should monitor the activity of liver enzymes and creatinine in the urine.
In patients older than 65 years or with pronounced signs of renal and / or hepatic impairment or hypoalbuminemia necessary to carry out the dose adjustment.
In the treatment of flupirtine possible false positive reactions with diagnostic test strips for bilirubin, urobilinogen and protein in urine. A similar reaction is possible in the quantitative determination of bilirubin in the blood plasma.
In applying the drug in high doses, in some cases there may be a urine stain in the color green, which is not a clinical sign of any disease.
Given that flupirtine can attenuate attention and slow responses of the body, it is recommended during treatment with refrain from driving and transport activities potentially hazardous activities that require high concentration and psychomotor speed reactions.
Katadolon Forte Inside, with liquid squeezed small amount of liquid (100 ml), 1 table. 1 per day. The maximum daily dose - 400 mg.
If the pain continues to bother, it is necessary to consider additional treatment other analgesics. The duration of therapy is determined by the attending physician and depends on the dynamics of pain and tolerance.
During treatment should regularly monitor the activity of serum liver enzymes and the concentration of creatinine in urine.
It enhances the effect of alcohol, sedatives and muscle relaxants.
Due to the fact that flupirtine protein bound, one should consider the possibility of its replacement by other medications taken concurrently.
Thus, it is shown that warfarin and diazepam flupirtine are displaced from the protein binding that while their reception can lead to an enhancement of their activity.
When concomitant administration of flupirtine and coumarin derivatives should regularly monitor the performance of Quick (prothrombin index) in order to avoid possible action or to reduce the dose of coumarin.
Data on the interaction with other anticoagulant and antiplatelet agents is not (acetylsalicylic acid, etc..).
With simultaneous use of flupirtine with drugs that are also metabolized by the liver, it requires regular monitoring of the level of "liver" enzymes.
Avoid combined use of flupirtine and medicines containing paracetamol and carbamazepine.
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