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Fokusin - blocker of α1-adrenergic receptors. Selectively and competitively blocks postsynaptic α1A-adrenergic receptors located in the smooth muscles of the prostate gland, the neck of the bladder and the prostatic part of the urethra, as well as α1D-adrenoreceptors, mainly located in the body of the bladder. This leads to a decrease in the tone of the smooth muscles of the prostate gland, the neck of the bladder and the prostatic part of the urethra and improve detrusor function. This reduces the symptoms of obstruction and irritation associated with benign prostatic hyperplasia. Typically, the therapeutic effect develops 2 weeks after the start of the drug, although in a number of patients, the decrease in the severity of symptoms is noted after the first dose.
Hypersensitivity to the components of the drug.
With caution: chronic renal failure (lower creatinine clearance below 10 ml / min), arterial hypotension (including orthostatic), severe hepatic impairment.
Fokusin is prescribed inside at a dose of 400 mcg (1 caps.) Per day. Capsules are taken after the first meal, with plenty of water. It is not recommended to chew the capsule.
Tamsulosin should be used with caution in patients with a predisposition to orthostatic hypotension. At the first signs of orthostatic hypotension (dizziness, weakness), the patient should be seated or laid.
Before using the drug, it is necessary to verify the diagnosis.
During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities requiring increased focus and speed of psychomotor reactions.
Rarely, headache, dizziness, asthenia, sleep disturbance (drowsiness or insomnia), retrograde ejaculation, decreased libido, back pain, rhinitis, nausea, vomiting, constipation, or diarrhea.
In isolated cases - orthostatic hypotension, tachycardia, palpitations, pain in the chest.
In extremely rare cases - hypersensitivity reactions (skin rash, itching, angioedema).
There were no cases of acute drug overdose.
Symptoms: it is theoretically possible the emergence of acute hypotension.
Treatment: Carry out cardiotropic therapy. If symptoms persist, replace vasoconstrictive solutions or vasoconstrictors. To prevent further absorption of tamsulosin, it is possible to wash the stomach, taking activated charcoal or osmotic laxative.
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