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Betamaks (Betamax, Sulpiridum,Sulpiride) - antidepressant, antipsychotic, neuroleptic.
Blocks dopaminergic receptors of the limbic system (the system operates on neostriatnuyu slightly). It does not have a significant effect on the noradrenergic, acetylcholine, serotonin, histamine and GABA receptors.
Peripheral effects of the drug based on the inhibition of presynaptic receptor (mood improvement associated with increased amounts of dopamine in the central nervous system, and the development of symptoms of depression - to decrease). Antipsychotic effect of the drug is in a dose of 600 mg per day, and stimulating antidepressant - in doses up to 600 mg per day.
In smaller doses may be used as an adjunct in the treatment of psychosomatic diseases, including for the relief of negative mental symptoms of gastric ulcer and duodenal ulcer. When irritable bowel syndrome reduces the intensity of abdominal pain and leads to an improvement of the clinical condition of the patient.
Low-dose (50-300 mg per day) are effective in dizziness, regardless of etiology. It stimulates the secretion of prolactin and has a central antiemetic effect (inhibition of the vomiting center).
Indications Betamax drug:
Schizophrenia (acute and chronic), delirious state, depression, neurosis, vertigo, including with vertebrobasilar insufficiency, vestibular neuritis, Ménière's disease, traumatic brain injury, otitis media. Gastric ulcer and duodenal ulcer and irritable bowel syndrome (as adjuvant therapy).
Inside, in the first half of the day (16 hours), due to the increased level of wakefulness. The maximum daily dose - 1600 mg.
Schizophrenia, psychosis, delirium: the initial dose - 600-1200 mg per day, in divided doses; supporting - 300-800 mg per day.
Depression, from 150-200 mg to 600 mg per day in divided doses.
Dizziness: 150-200 mg / day, in severe conditions - up to 300-400 mg per day. The course of treatment - at least 14 days.
Peptic ulcer and duodenal ulcers, irritable bowel syndrome as adjuvant therapy: 100-300 mg per day in 1-2 reception.
Patients of advanced age: the initial dose - 1 / 4-1 / 2 the adult dosage.
Children over 14 years: 3-5 mg / kg.
When Cl creatinine 30-60 ml / min dose of 70% of the standard, or 1.5 times increase the interval between doses; Cl creatinine at 10-30 ml / min - 50% or 2-fold; less than 10 ml / min - 34%, or 3 times (dose reduction or increase in the interval between doses, respectively).
Symptoms: blurred vision, hypertension, sedation, nausea, extrapyramidal disorder, dry mouth, vomiting, excessive sweating, gynaecomastia.
Treatment: symptomatic therapy.
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