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Adepress (Paroxetinum, Paroxetine) - an antidepressant. It is a selective serotonin reuptake inhibitor (5-hydroxytryptamine, 5-HT) neurons in the brain, which determines its antidepressant action and effectiveness in the treatment of obsessive-compulsive (OCD) and panic disorder.
Paroxetine has low affinity for m-holinoretseptorami (possesses weak anticholinergic effects), α1-, α2- and β-adrenoceptors and for the dopamine (D2), 5HT1-like, 5HT2-like and histamine H1-receptors. Paroxetine does not violate psychomotor function and does not potentiate the inhibitory effect of ethanol on them.
According to the study of behavior and EEG paroxetine revealed weak activating properties when it is administered in doses higher than those required for inhibition of serotonin reuptake. In healthy volunteers, it does not cause a significant change in the level of blood pressure, heart rate and EEG.
Precautions: hepatic failure, renal failure, angle-closure glaucoma, prostatic hyperplasia, mania, heart disease, epilepsy, convulsive states, while the appointment of electro-therapy, simultaneous administration of drugs that increase the risk of bleeding, presence, increase the risk of increased bleeding and disease risk factors bleeding, as well as elderly patients.
In order to avoid the development of neuroleptic malignant syndrome should be administered with caution Adepress patients taking antipsychotics.
Elderly patients while taking Adepress possible hyponatremia.
In some cases, a dose adjustment of insulin used at the same time and / or oral hypoglycemic drugs.
With the development of seizures, treatment Adepress stop.
At the first sign of mania medication should be discontinued.
During the first few weeks of therapy Adepress should be carefully monitored for the patient's condition in relation to possible suicide attempts.
During therapy Adepress should refrain from drinking alcohol in connection with the strengthening of its toxic effect.
Effects on ability to drive vehicles and management mechanisms
Despite the fact that Paroxetine does not impair cognitive and psychomotor function, patients should abstain or exercise extreme caution when driving and when engaging in other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Tablets Adepress accept 1 time / day, in the morning, during a meal, not liquid, squeezed water.
The dose is adjusted individually for the first 2-3 weeks after initiation of therapy and subsequently adjusted if necessary. The effect develops more gradually. The dosage should be increased by 10 mg per week to achieve a therapeutic effect. The maximum daily dose should not exceed 60 mg / day.
In renal and / or liver failure, the recommended dose is 20 mg / day.
For older patients the daily dose should not exceed 40 mg.
To prevent relapses necessary supportive therapy. After the disappearance of the symptoms of depression may be the course of 4-6 months, while obsessional disorders and panic - more than 4-6 months.
Avoid abrupt withdrawal of the drug. In order to prevent the development of withdrawal Adepress discontinuation of the drug should be made gradually.
From the central and peripheral nervous system: often - drowsiness or insomnia, tremor, fatigue, dizziness, anxiety; sometimes - confusion, hallucinations, extrapyramidal disorder, paraesthesia, decreased ability to concentrate; rarely - seizures, mania; very rarely - serotonin syndrome (agitation, hyperreflexia, diarrhea), panic disorder.
From the senses: in some cases - blurred vision, mydriasis.
From the musculoskeletal system: rarely - myasthenia gravis, myoclonus, arthralgia, myalgia.
From the urinary system: frequent urination; rarely - urinary retention.
From the reproductive system: ejaculation disorders, libido disorders; rarely - hyperprolactinemia / galactorrhea, anorgasmia.
From the digestive system: loss of appetite, nausea, vomiting, dry mouth; sometimes - constipation or diarrhea; in some cases - hepatitis.
Since the cardiovascular system: orthostatic hypotension.
Allergic reactions: seldom - rash, hives, ekhimatozy, itching, angioedema.
Other: increased sweating; in rare cases - hyponatremia, inappropriate secretion of antidiuretic hormone.
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