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Active substance Methylprednisolone

ATX Code H02AB04 Methylprednisolone

Pharmacological group


Nosological classification (ICD-10)

D69.3 Idiopathic thrombocytopenic purpura

Werlhof's disease, Idiopathic autoimmune thrombocytopenia, Idiopathic thrombocytopenic purpura of adults, Idiopathic thrombocytopenic purpura in adults, Immune idiopathic thrombocytopenic purpura, Immune thrombocytopenia, Bleeding in patients with thrombocytopenic purpura, Evans Syndrome, Thrombocytopenic purpura, Thrombocytopenia of immune origin, Chronic idiopathic thrombocytopenic purpura, Essential thrombocytopenia, Autoimmune thrombocytopenic purpura in pregnancy, Posttransfusion purpura

J45 Asthma

Asthma physical effort, status asthmaticus, Bronchial asthma, Asthma lung flow, Bronchial asthma with obstruction of sputum discharge, Bronchial asthma heavy currents, Bronchial asthma physical effort, hypersecretory asthma, Hormone-dependent form of bronchial asthma, Relief of asthma attacks in bronchial asthma, Non-allergic asthma, nocturnal asthma, Exacerbation of asthma, Asthma attacks, Endogenous forms of asthma, Night asthma, Cough with bronchial asthma

K50 Crohn's disease [regional enteritis]

Crohn's disease, Crohn's disease with fistula, Granuloma of the intestine, Granulomatous enteritis, Crohn's disease, Regional ileitis, Terminal Ileitis, Enteritis regional

K51 Ulcerative colitis

Colitis acute ulcerative, Colitis ulcerative, Ulcerative-necrotic colitis, Colitis ulcerative-hemorrhagic nonspecific, Colitis ulcerative and trophic, Colitis ulcerative idiopathic, Colitis ulcerative nonspecific, Nonspecific ulcerative colitis, Proctocolitis ulcers, Hemorrhagic purulent rectoxitis, Rectoccolitis ulcerative-hemorrhagic

L10 Pemphigus [pemphigus]

Benign pemphigoid of mucous membranes, Bubble dermatosis, Pemphigus, Dermatitis, vesicular, Benign pemphigus, Ordinary pemphigus, Pemphigus, Bubble dermatitis, Family benign pemphigus Hailey-Hailey

M30-M36 Systemic involvement of connective tissue


M71 Other bursopathies

Bursitis, Bursopathy, Diseases of soft tissues, Osteoarthritis in musculo-articular diseases, Inflammatory disease of soft tissues, Subacute bursitis

M77.9 Other unspecified

Capsule, Periarthritis, Tendonitis, Tendopathy, Periarthropathy

M79.0 Other unspecified rheumatism

Degenerative rheumatic disease, Degenerative and rheumatic diseases of the tendons, Degenerative rheumatic diseases, Localized forms of rheumatism of soft tissues, Rheumatism, Rheumatism with a pronounced allergic component, Rheumatism of the articular and extraarticular, Rheumatic attack, Rheumatic complaints, Rheumatic diseases, Rheumatic disease of the spine, Relapses of rheumatism, Articular and extra-articular rheumatism, Articular and muscular rheumatism, Articular rheumatism, Articular syndrome with rheumatism, Chronic rheumatic pain, Chronic articular rheumatism, Rheumatoid diseases, Rheumatic diseases of the intervertebral disc

N04 Nephrotic syndrome

Nephrosis, Edema of the kidneys, Nephrotic syndrome, Lipoid nephrosis, Nephrotic syndrome without uremia, Acute nephrotic syndrome, Edematic syndrome of renal genesis, Renal form of diabetes insipidus, Segmental glomerulonephritis, Focal glomerulonephritis, Family Nephrotic Syndromes, Chronic nephrotic proteinuric syndrome, Lipiduria, Jade hereditary, Nephrotic-proteinuric syndrome

T78.4 Allergy, unspecified

Allergic reactions to insulin, Allergic reactions to insect stings, Allergic reactions similar to systemic lupus erythematosus, Allergic diseases, Allergic diseases of mucous membranes, Allergic diseases and conditions resulting from increased release of histamine, Allergic diseases of mucous membranes, Allergic symptoms, Allergic symptoms in the mucous membranes, Allergic reactions, Allergic reactions caused by insect bites, Allergic reactions, Allergic conditions, Allergic laryngeal edema, allergopathy, allergic conditions, Allergy, House dust allergy, Anaphylaxis, Cutaneous reactions to medications, Skin reaction to insect stings, Cosmetic allergy, Drug allergy, Acute allergic reaction, Laryngeal edema allergic genesis and background radiation, Food and drug allergy

Composition and form of release

1 ampoule or 1 bottle of dry substance for the preparation of the injection solution contains methylprednisolone (in the form of hydrogensuccinate sodium salt) 250 or 1000 mg respectively; Complete with a solvent (water for injection) in ampoules of 5 and 10 ml, in package 1 and 5 or 1 set, respectively.

pharmachologic effect

Pharmacological action - anti-inflammatory, antiallergic, immunosuppressive.

Replenishes the relative or absolute lack of endogenous glucocorticoids.


Stabilizes cell membranes, reduces the permeability of capillaries, improves microcirculation. Increases the level of glucose in the blood, stimulates catabolism, breaks the mineralization of bone tissue; Causes immunodepression (associated with inhibition of the release of cytokines - interleukin 1,2, gamma-interferon - from lymphocytes and macrophages).


Shock (anaphylactic, burn, traumatic, cardiogenic), cerebral edema, shock lung, asthmatic status, Addison's crisis, Waterhouse-Frideriksen syndrome, immunological incompatibility crisis in organ transplantation.


Hypersensitivity. For long-term use not according to vital indications: stomach ulcer and duodenal ulcer, severe osteoporosis; Psychic disorders (including history), herpes simplex, herpes zoster (viremic form), chickenpox, from 8 weeks to 2 weeks after vaccination, amoebiasis, systemic mycoses, poliomyelitis (except bulbar-encephalic forms), Lymphoma, developing after vaccination with BCG, glaucoma.

pregnancy and lactation

It is permissible, but only on strict indications (breastfeeding should be suspended).

Side effects

With long-term use - lunar face, obesity, muscle weakness, hypertension, osteoporosis, decreased glucose tolerance, diabetes mellitus, violation of the secretion of sex hormones (amenorrhea, hirsutism, impotence); Striae, petechiae, ecchymosis, steroid acne, edema, sodium retention in tissues, increased excretion of potassium, atrophy of the adrenal cortex, vasculitis, unpleasant sensations in the epigastrium, ulcerative lesions of the stomach or duodenum, increased risk of infectious diseases, immune processes, slowing healing of wounds , Growth retardation in children, aseptic necrosis of the bones (head of the femoral and humerus), glaucoma, cataract, mental disorders, increased risk of thrombosis, pancreatitis.


Increases the toxicity of cardiac glycosides; Reduces the hypoglycemic activity of antidiabetic drugs, anticoagulant - coumarin derivatives, increases the excretion of potassium by saluretics and the risk of gastrointestinal bleeding against the background of anti-inflammatory drugs. The effect is reduced by barbiturates, rifampicin and phenytoin.

Dosing and Administration

In / in, slowly. Adults - 250-1000 mg once or several times a day; Children - from 4 to 20 mg / kg body weight. The interval between the injections is from 30 minutes to 24 hours. In case of shock lung, cardiogenic shock, cerebral edema, asthmatic status, in the initial stage of hypovolemic shock - up to 30 mg / kg of body weight. The contents of the ampoule are dissolved in 5 (250 mg) or 10 (1000 mg) of water for injection.

Precautionary measures

When a serious infection is necessary, a combination with antibiotic therapy. For particularly strict indications, children are prescribed.

storage Conditions

In dry, the dark place at a temperature of no higher than 25 C.

Keep out of the reach of children.

Shelf life

5 years.

Do not use after the expiry date printed on the package.

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