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Instruction for use: Upsarin UPSA with Vitamin C

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Active substance Acetylsalicylic acid + Ascorbic acid

ATX code N02BA51 Acetylsalicylic acid in combination with other drugs, except for psycholeptics

Pharmacological groups

NSAIDs - Salicylic acid derivatives in combinations

Nosological classification (ICD-10)

R50 Fever of unknown origin

Malignant hyperthermia, Hyperthermia malignant

R52.2 Other constant pain

Pain syndrome, rheumatic origin, Pain at vertebral lesions, Pain in the chamber, Pain for burns, Pain syndrome weak or moderate, Perioperative pain,Moderate to severe pain, Moderately or weakly expressed pain syndrome, Moderate to severe pain, Ear pain of otitis, Neuropathic pain, neuropathic pain

Composition and form of release

1 effervescent tablet contains acetylsalicylic acid 330 mg and ascorbic acid (vitamin C) 200 mg; in a tube 10 pcs., in a box 1 tuba.

pharmachologic effect

Pharmacological action - anti-inflammatory, antipyretic, antiaggregational, analgesic, replenishing vitamin C deficiency.

Inhibits the biosynthesis of PG (prostaglandins). In the focus of inflammation reduces the permeability of capillaries, reduces the activity of hyaluronidase, inhibits the formation of ATP (adenosine triphosphate). Reduces the excitability of the centers of thermoregulation and pain sensitivity, reduces the algogenic effect of bradykinin.


Quickly absorbed, undergoing hydrolysis with the formation of pharmacologically active metabolite - salicylic acid. Cmax in the blood is reached after 2-4 hours. It is excreted as metabolites mainly with urine. T1 / 2 - from 3 to 9 hours.


Increase in temperature with influenza, catarrhal and other infectious and inflammatory diseases, weak and moderate pains of different origin.


Hypersensitivity (including to other NSAIDs (nonsteroidal anti-inflammatory drugs)), gastric ulcer and / or duodenal ulcer in the acute stage, gout, bronchial asthma, urolithiasis (if the dose of vitamin C exceeds 1 g / day), increased tendency to bleeding, children's age (up to 15 years).

pregnancy and lactation

Contraindicated in the third trimester of pregnancy.

Side effects

On the part of the digestive tract (gastrointestinal tract): in some cases - nausea, vomiting, abdominal pain, diarrhea.

On the part of the hemostasis system: hemorrhagic syndrome is possible (nosebleeds, bleeding gums, gastrointestinal bleeding, etc.).

Allergic reactions: urticaria, bronchospasm, angioedema.

Dosing and Administration

Inside, dissolving the tablet in a glass of water immediately before use. Adults and children over 15 years of age with a body weight of 50 kg or more: 1-2 tablets. 6 times a day (but not more than 9 tablets per day), the maximum daily dose is 3 g. Elderly: 1-2 tablets. after 4 hours (but not more than 6 tablets per day), the maximum daily dose is 2 g.

Precautionary measures

It is not recommended to combine with other NSAIDs, with anticoagulants, uricosuric agents, hypoglycemizing drugs, glucocorticoids, ticlopidine, diuretics, antihypertensive agents, nonabsorbable antacids, antibiotics (possibly mutual weakening of effects), with interferon-alpha. It is not recommended to be used in combination with methotrexate. The drug should be administered with caution in case of a history of peptic ulcer of the stomach or duodenum.

storage Conditions

In a dry place, at a temperature of no higher than 30 ° C. In a sealed package.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiry date printed on the package.

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