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Instruction for use: Tetralgin

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ATX Code N02BB72 Metamizole sodium in combination with psycholeptics

Pharmacological group

NSAIDs - Pyrazolones in combinations

Nosological classification (ICD-10)

J22 Acute respiratory infection of lower respiratory tract, unspecified

Bacterial respiratory disease, Bacterial infections of the lower respiratory tract, Bacterial infections of the respiratory system, Viral respiratory disease, Viral respiratory tract infections, Inflammatory respiratory diseases, Difficult sputum separation in acute and chronic respiratory diseases, Respiratory tract infections, Respiratory and lung infections, Lower respiratory tract infections, Infections of the lower respiratory tract, Infectious inflammation of the respiratory tract, Infectious diseases of the respiratory tract, Infectious diseases of the lungs, Infectious diseases of the respiratory system, Respiratory tract infection, Cough for colds, Pulmonary infection, Acute respiratory tract infection, Acute respiratory viral infection, Acute inflammatory airway disease, Acute respiratory disease, Respiratory infection, Respiratory and viral infections, Respiratory syncytial viral infection in young children, Respiratory diseases, Respiratory infections

K08.8.0 * Painful toothache

Dentinal pain, Dentinal pains, Pain pulpitis, Anesthesia in dentistry, Pain syndromes in dental practice, Pain after removal of tartar, Pain when extracting a tooth, Toothache, Pain after dental interventions

M25.5 Pain in the joint

Arthralgia, Pain syndrome in musculo-articular diseases, Pain syndrome in osteoarthritis, Pain syndrome in osteoarthritis, Pain syndrome in acute inflammatory diseases of the musculoskeletal system, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the joints, Soreness of the joints, Soreness of joints in severe physical exertion, Painful inflammatory joint damage, Painful conditions of the musculoskeletal system, Painful joint conditions, Painful traumatic affection of joints, Pain in the musculoskeletal system, Pain in Shoulder Joints, Pain in the joints, Joint pain, Joint pain with injuries, Musculoskeletal pain, Pain with osteoarthritis, Pain in the pathology of the joints, Pain in rheumatoid arthritis, Pain in chronic degenerative bone diseases, Pain in chronic degenerative joint diseases, Bone-joint pain, Joint pain, Arthritic pain of rheumatic origin, Articular pain syndrome, Joint pain, Rheumatic pain, Rheumatic pains

M79.1 Myalgia

Myofascial pain syndromes ,Pain syndrome in musculo-articular diseases, Pain syndrome in chronic inflammatory diseases of the musculoskeletal system, Pain in the muscles, Tenderness of muscles, Muscular soreness in severe physical exertion, Painful conditions of the musculoskeletal system, Pain in the musculoskeletal system, Pain in the muscles, Pain at rest, Muscle aches, Muscle pain, Musculoskeletal pain, Myalgia, Muscle pain, Muscle pain at rest, Muscle pain, Muscular pain of non-rheumatic origin, Muscle pain of rheumatic origin, Acute muscle pain, Rheumatic pain, Rheumatic pains, Myofascial syndrome, Fibromyalgia

M79.2 Neurology and neuritis, unspecified

Pain syndrome with neuralgia, Brachialgia, Occipital and intercostal neuralgia, Neuralgia, Neuralgic pain, Neuralgia, Neuralgia of intercostal nerves,Neuralgia of the posterior tibial nerve, Neuritis, Neuritis traumatic, Neuritis, Neurological Pain Syndromes, Neurological contractures with spasms, Acute neuritis, Peripheral neuritis,Post-traumatic neuralgia,Severe pain of a neurogenic nature, Chronic neuritis, Essential neuralgia

N94.6 Dysmenorrhea Unspecified

Pain during menstruation, Functional disorders of the menstrual cycle, Menstrual cramps, Emmeniopathy, Pain during menstruation, Painful menstrual irregularities, algomenorrhea, algomenoreya, Pain smooth muscle spasm, Pain spasm of smooth muscles (renal and biliary colic, intestinal spasms, dysmenorrhea), Pain spasm of smooth muscles of internal organs (kidney and biliary colic, intestinal spasms, dysmenorrhea), Disalgomenoreya, dysmenorrhea, Dysmenorrhea (essential) (Exfoliative), menstrual disorder, menstruation painful, metrorrhagia, Violation of the menstrual cycle, Menstrual irregularities, Prolaktinzavisimoe menstrual disorders, Prolaktinzavisimoe menstrual dysfunction, Pain spasm of smooth muscles of internal organs, Spasmodic dysmenorrhea, Primary disalgomenoreya

R51 Headache

Pain in the head, Cephalgia, Pain with sinusitis, Pain in the back of the head, Painful headache, Headache of vasomotor genesis, Headache of vasomotor origin, Headache with vasomotor disorders, Headache, Neurological headache, Serial headache

Composition and form of release

Tablets 1 table.

codeine 8 mg

caffeine 50 mg

metamizole sodium 300 mg

Phenobarbital 10 mg

in a planar cell pack of 10; in a pack of cardboard 1 or 2 packages; or in polymer bottles of 20 pcs .; in a pack of cardboard 1 bottle.


Combined drug.

pharmachologic effect

Pharmacological action - analgesic, miorelaksiruyuschee, antitussive, sleeping pills.


Metamizole sodium is an analgesic. Caffeine stimulates the psychomotor centers of the brain, has an analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, increases physical and mental performance. Codeine - antitussive drug of central action, reduces the excitability of the cough center. Phenobarbital has a sleeping-sedative and central muscle relaxant effect.








ARVI (symptomatic therapy).



hepatic and / or renal insufficiency;


deficiency of glucose-6-phosphate dehydrogenase;




lactation period;

conditions accompanied by respiratory depression;

intracranial hypertension;



arterial hypotension;

alcoholic intoxication.

With caution - the elderly.

pregnancy and lactation

Contraindicated in pregnancy. For the duration of treatment, breastfeeding should be discontinued.

Side effects

Allergic reactions (rash, itching, urticaria), dizziness, drowsiness, tachycardia, nausea, vomiting, constipation; leukopenia, granulocytopenia, agranulocytosis. With prolonged uncontrolled admission in high doses - addiction (weakening analgesic effect) and drug dependence, due to the presence of codeine; hepatic and / or renal failure.


With the simultaneous use of drugs that depress the central nervous system, it is possible to increase the sedative effect and depressant effect on the respiratory center. Strengthens the action of ethanol on psychomotor reactions. Simultaneous use with phenothiazine derivatives can lead to the development of severe hyperthermia. With the simultaneous administration of cyclosporine, the concentration of the latter in the blood decreases. Metamizole sodium, displacing from the bond with protein oral hypoglycemic drugs, indirect anticoagulants, GCS and indomethacin, increases their activity. Phenylbutazone, barbiturates and other inducers of microsomal liver enzymes with simultaneous administration decrease the effectiveness of metamizole sodium.

Tricyclic antidepressants, oral contraceptives, allopurinol disrupt the metabolism of metamizole sodium in the liver and increase its toxicity.

Dosing and Administration

Inside, 1 tab. 1-3 times a day. The maximum daily dose is 4 tablets. The course of treatment is no more than 5 days.


Symptoms: nausea, vomiting, gastralgia, tachycardia, arrhythmias, oppression of the respiratory center.

special instructions

For prolonged (> 1 week) treatment, monitoring of the peripheral blood picture and the functional state of the liver is necessary. It is necessary to refrain from potentially dangerous activities requiring increased attention, because the drug slows the reaction rate and causes drowsiness.

Can change the results of doping control in athletes. It is difficult to establish a diagnosis with an acute abdomen. In patients with atopic bronchial asthma, pollinosis, there is an increased risk of allergic reactions.

storage conditions

In a dry, the dark place at a temperature of no higher than 25 C.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiry date printed on the package.

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