Instruction for use: Terrilytin

Dosage form

Liofilizate for the preparation of a solution for external use.

Composition

Active substance:

The enzyme terrylitin, obtained from native solutions of Aspergillus terricola H-20.

Description of dosage form

The porous mass or powder is white, or white with a yellowish tint of color, odorless. Hygroscopic.

Pharmacological group

Proteolytic agent.

Pharmacodynamics

Terrilytin® is a proteolytic enzyme, the product of the life of a mold fungus. Its application is based on the ability to cleave necrotic tissue, dilute purulent exudate and blood clots.

Indications

Purulent wounds, burns, trophic ulcers, pressure sores.

Contraindications

Hypersensitivity to the drug, bleeding ulcers and wounds, ulceration of malignant tumors, pregnancy, lactation.

Simultaneous use of thrombolytic agents.

Carefully.

The location of the main blood vessel in the wound; diseases accompanied by delayed blood clotting.

Dosing and Administration

Outer in the form of a solution containing in 1 ml 40-50 PE (Proteolytic Units).

Before use, the contents of one vial (200 PE) are dissolved in 4-5 ml, or in 2-2.5 ml (100 PE) of purified water, in 0.9% sodium chloride solution or 0.25% novocaine solution.

The solution is moistened with a sterile napkin, which is applied to the wound and covered with a moisture-proof dressing.

In the treatment of deep burns and other lesions with a large number of necrotic tissues and for the rejection of the scab, Terrylitin® is used in powder form, dusting the affected surface. A sterile napkin, slightly moistened with 0.9% sodium chloride solution or 0.25% novocaine solution, and a waterproof dressing are applied on top. Change dressings produced after 1-2 days. At the same time, the areas of necrotically altered tissues are removed, the surface is washed with a 3% solution of hydrogen peroxide, died and again powdered with Terrilytin® powder.

Treatment with Terrilytin® continues until complete rejection of necrotic tissues, melting of fibrinous-purulent deposits and the formation of pure, juicy granulations.

Side effects

Allergic reactions.

Overdose

Cases of overdose are not described.

Interaction

Terrilytin® promotes better penetration into the inflammatory focus of other medicines, is compatible with antibiotics: lincomycin, ampiox, streptomycin, ampicillin.

The drug is compatible with antimicrobial and other chemotherapeutic agents.

special instructions

When external application of Terrylitin ® is necessary to ensure sufficient drainage of the wound.

Do not administer intravenously.

Form of issue

Lyophilizate for the preparation of a solution for external use of 100 or 200 PE in ampoules or glass bottles.

For 10 ampoules (bottles) in a box or pack of cardboard with instructions for use, ampoule scarifier.

For 1, 3 or 5 ampoules (vials) in a contour mesh box with instructions for use and a scapegrator ampoule in packs or boxes of cardboard.

Storage conditions

In a dry, dark place at a temperature of 0 to 10 ° C.

Keep out of the reach of children.

Shelf life

3 years.

Do not use after the expiration date.

Conditions of leave from pharmacies

Let go on prescription.