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Instructions

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Instruction for use: Terbutaline (Terbutalinum)

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chemical name 5- [2 - [(1,1-dimethylethyl) amino] -1-hydroxyethyl] -1,3-benzenediol (as sulfate)

Pharmacotherapeutic group:

Beta-adrenergic agonist

The nosological classification (ICD-10)

J42 Chronic bronchitis, unspecified

recurrent bronchitis, Bronchitis asthma, wheeze bronchitis, chronic Bronchitis, Inflammatory airways disease, bronchi disease, Qatar smoker, Cough in inflammatory diseases of the lung and bronchus, Exacerbation of Chronic Bronchitis, Chronic bronchitis, Chronic obstructive pulmonary disease, Chronical bronchitis, Chronic bronchitis smokers, Chronic spastic bronchitis, allergic Bronchitis

J43 Emphysema

Interstitial emphysema, Emphysema, Chronic lung disease, Chronic obstructive pulmonary disease, Obstructive pulmonary emphysema, Chronic pulmonary emphysema, Chronic obstructive pulmonary emphysema

J44 Other chronic obstructive pulmonary disease

Allergic bronchitis, Bronchitis asthma, Asthmatic bronchitis, wheeze bronchitis, Bronchitis is an obstructive, bronchi disease, Shortness of sputum in acute and chronic respiratory diseases, Cough in inflammatory diseases of the lung and bronchus, Reversible airflow obstruction, Reversible obstructive airway disease, Obstructive bronchitis disease, Obstructive lung disease, Obstructive bronchitis, Spastic bronchitis, Chronic lung disease, Chronic nonspecific lung diseases, Chronic obstructive pulmonary disease, Chronic obstructive bronchitis, Chronic obstructive airway disease, Chronic obstructive pulmonary disease, Restrictive lung pathology

J45 Asthma

Asthma physical effort, status asthmaticus, Bronchial asthma, Asthma lung flow, Bronchial asthma with obstruction of sputum discharge, Bronchial asthma heavy currents, Bronchial asthma physical effort, hypersecretory asthma, Hormone-dependent form of bronchial asthma, Relief of asthma attacks in bronchial asthma, Non-allergic asthma, nocturnal asthma, Exacerbation of asthma, Asthma attacks, Endogenous forms of asthma, Night asthma, Cough with bronchial asthma

J98.8.0 * Bronchospasm

Bronchospasm in bronchial asthma, Bronchospasm when exposed to an allergen, bronchospastic reactions, bronchospastic status, bronhospastichesky syndrome, Diseases accompanied by bronchospastic syndrome, reversible bronchospasm, spasmodic cough

O20.0 Threatened abortion

Abortion threatening, threatening miscarriage, Spastic conditions with the risk of abortion, Threatened miscarriage in the first trimester of pregnancy, The threat of miscarriage, threatened abortion, The threat of miscarriage, Threatened spontaneous miscarriage

O60 Premature birth

Pregnancy prematurity, The birth premature, Preterm labor pains, Premature contractions prehospital, Immobilization of the uterus before the cesarean section, Immobilization of the uterus, Acute tocolysis, Threatening premature labor, Premature discharge of water, Preventing premature births, The threat of premature birth

Z100 * CLASS XXII Surgical practice

Abdominal surgery, adenomectomy, Amputation, Coronary angioplasty, Angioplasty of the carotid arteries, Antiseptic skin treatment for wounds, Antiseptic Hand, Appendectomy, atherectomy, Balloon coronary angioplasty, Vaginal hysterectomy, The coronary bypass, Interventions in the vagina and cervix, Interventions on the bladder, Intervention in the mouth, Restoration and reconstructive surgery, Hand hygiene of medical personnel, Gynecologic surgery, Gynecological intervention, Gynecological surgery, Hypovolemic shock during operations, Disinfection of purulent wounds, Disinfection of wounds edges, Diagnostic intervention, Diagnostic procedures, Cervical Diathermocoagulation, Long-surgery, Replacing the fistula catheters, Infection in orthopedic surgery, Artificial heart valve, cystectomy, Short-term outpatient surgery, Short-term operation, Short surgical procedures, Krikotireotomiya, Blood loss during surgery, Bleeding during surgery and in the postoperative period, Kuldotsentez, laser photocoagulation, laser coagulation, retinal laser coagulation, Laparoscopy, Laparoscopy in Gynecology, CSF fistula, Small gynecological operations, Small surgical procedures, Mastectomy and subsequent plastic, mediastinotomy, Microsurgical operations on the ear, Mukogingivalnye operation, suturing, Minor surgery, neurosurgical operation, Immobilization of the eyeball in ophthalmic surgery, testectomy, pancreatectomy, Perikardektomiya, The period of rehabilitation after surgery, The period of, convalescence after surgery, Percutaneous transluminal coronary angioplasty, Pleural thoracentesis, Pneumonia postoperative and posttraumatic, Preparation for surgical procedures, Preparation for surgery, Preparation of the surgeon's hands before surgery, Preparation of the colon for surgical procedures, Postoperative aspiration pneumonia in neurosurgical and thoracic surgery, Postoperative nausea, Postoperative bleeding, postoperative granuloma, postoperative shock, The early postoperative period, myocardial revascularization, Radiectomy, gastric Resection, bowel resection, uterine Resection, liver Resection, enterectomy, Resection of part of the stomach, Reocclusion of the operated vessel, Bonding tissues during surgical procedures, Removal of sutures, Condition after eye surgery, Condition after surgery, Condition after surgery in the nasal cavity, Condition after gastrectomy, Status after resection of the small intestine, Condition after tonsillectomy, Condition after removal of the duodenum, Condition after phlebectomy, Vascular surgery, Splenectomy, Sterilization of surgical instruments, Sterilization of surgical instruments, sternotomy, Dental surgery, Dental intervention in periodontal tissues, strumectomy, Tonsillectomy, Thoracic surgery, total gastrectomy, Transdermal intravascular coronary angioplasty, Transurethral resection, Turbinektomiya, Removal of a tooth, cataract surgery, Removal of cysts, tonsillectomy, Removal of fibroids, Removing the mobile primary teeth, Removing polyps, Removing broken tooth, Removal of the uterus body, Removal of sutures, Urethrotomy, Fistula likvoroprovodyaschih ways, Frontoetmoidogaymorotomiya, Surgical infection, Surgical treatment of chronic limb ulcersm, Surgery, The surgery in the anal area, The surgery on the colon, Surgical practice, The surgical procedure, Surgical interventions, Surgery on the gastrointestinal tract, Surgical procedures on the urinary tract, Surgical procedures on the urinary system, Surgical intervention of the genitourinary system, Surgical procedures on the heart, Surgical manipulation, surgery, Surgery on the veins, Surgical intervention, Vascular surgery, Surgical treatment of thrombosis, cholecystectomy, Partial gastric resection, transabdominal hysterectomy, Percutaneous transluminal coronary angioplasty, Percutaneous transluminal angioplasty, Coronary artery bypass, tooth Extirpation, Extirpation of milk teeth, pulpectomy, pulsative cardiopulmonary bypass, tooth Extraction, teeth Extraction, cataract extraction, Electrocoagulation, endourological intervention, episiotomy, Etmoidotomiya, Complications after tooth extraction

CodeCAS 23031-25-6

Description

crystalline powder from white to gray-white, odorless or with a faint odor of acetic acid. Soluble in water and 0.1N. hydrochloric acid, poorly soluble in methanol, insoluble in chloroform.

Pharmacological Properties Pharmachologic effect
tocolytic, anti-allergic, a bronchodilator.

Selectively excites the beta2-adrenergic receptors increases adenylate cyclase activity, cAMP stabilizes, reduces the concentration of intracellular calcium and relaxes the smooth muscles. Relaxing longitudinal bronchial muscles (a bronchodilator effect), reduces the viscosity of bronchial secretions, increases the mobility of the cilia of ciliated epithelium (mucociliary improves Cl). It stabilizes the membranes of fat cells (anti-allergic effect), inhibits the release of mediators of allergy (serotonin, histamine, etc.). It relaxes smooth muscles of the uterus (tocolytic effect).

After inhalation slowly absorbed from the respiratory tract (most of the ingested and absorbed from the gastrointestinal tract). When s / to the introduction of Cmax achieved within 15-30 minutes. It does not cross the BBB, but passes through the placental barrier. Under intense biotransformation in the liver to inactive metabolites. Excreted by the kidneys, intestines, lactating mammary glands. T1 / 2 of 4 h.

The action starts after 30 minutes n / k administration clinically significant improvement in respiratory function is observed after 60-120 minutes, reaching a maximum within 120-180 minutes and lasts for up to 4 hours.

Indications for Terbutaline

Bronchial asthma, asthmatic status, obstructive bronchitis, emphysema, congestive heart failure, fibrotic cystitis, primary dysmenorrhea, threatened premature labor, fetal distress.

Contraindications

Hypersensitivity, pregnancy (as bronchodilatory agents), breast-feeding, child age (under 12 years).

Pregnancy and breast-feeding

Category effects on the fetus by FDA - B.

Side effects of Terbutaline

Anxiety, insomnia, headache, dizziness, tremors, sweating, hyperreflexia, weakness, dilated pupils, tachycardia, arrhythmias, palpitations, hyper- or hypotension, nausea, heartburn, vomiting, unpleasant taste in the mouth, atony bladder, allergic reactions.

Interaction

It increases the activity of other agonists, the likelihood of adverse events antidepressants (tricyclics and MAO inhibitors). Blockers, especially beta-adrenolytics reduce the effect.

Overdose

Symptoms: tremor, nervousness, impaired consciousness, seizures, headache, sweating, tachycardia, arrhythmia, extrasystoles, hypotension, nausea, vomiting, hyperglycemia, hypoglycemia alternating with.

Treatment: gastric lavage, the appointment of activated carbon, maintaining vital functions.

Routes of administration

Inside, n / a, inhalation.

Precautions substance Terbutaline

With the development of paradoxical bronchospastic reaction in response to a aerosol administration of terbutaline overturned.

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