Instruction for use: Reviparin sodium

Trade name of the drug – Clivarin

The Latin name of the substance Reviparin sodium

Reviparinum natrium (genus. Reviparini natrii)

Chemical name

Low molecular weight heparin with an average molecular weight of 3500-4500 in the form of the sodium salt

Pharmacological group:

Anticoagulants

The nosological classification (ICD-10)

I82 Embolism and thrombosis of other veins: Recurrent venous thrombosis; Postoperative thrombosis; Venous thrombosis; Acute venous thromboembolism; Recurrent vein thrombosis; Venous thrombosis; Thrombosis of veins of internal organs; Venous thrombosis; Deep vein thrombosis; Thrombosis of blood vessels; Vascular thrombosis; Thrombosis of veins; Deep vein thrombosis; Thromboembolic diseases; Thromboembolism of veins; Severe venous thrombosis; Embolism; Embolism of veins; Thromboembolic complications

Z100 * CLASS XXII Surgical practice: Abdominal surgery; adenomectomy; Amputation; Coronary angioplasty; Angioplasty of the carotid arteries; Antiseptic skin treatment for wounds; Antiseptic Hand; Appendectomy; atherectomy; Balloon coronary angioplasty; Vaginal hysterectomy; The coronary bypass; Interventions in the vagina and cervix; Interventions on the bladder; Intervention in the mouth; Restoration and reconstructive surgery; Hand hygiene of medical personnel; Gynecologic surgery; Gynecological intervention; Gynecological surgery; Hypovolemic shock during operations; Disinfection of purulent wounds; Disinfection of wounds edges; Diagnostic intervention; Diagnostic procedures; Cervical Diathermocoagulation; Long-surgery; Replacing the fistula catheters; Infection in orthopedic surgery; Artificial heart valve; cystectomy; Short-term outpatient surgery; Short-term operation; Short surgical procedures; Krikotireotomiya; Blood loss during surgery; Bleeding during surgery and in the postoperative period; Kuldotsentez; laser photocoagulation; laser coagulation; retinal laser coagulation; Laparoscopy; Laparoscopy in Gynecology; CSF fistula; Small gynecological operations; Small surgical procedures; Mastectomy and subsequent plastic; mediastinotomy; Microsurgical operations on the ear; Mukogingivalnye operation; suturing; Minor surgery; neurosurgical operation; Immobilization of the eyeball in ophthalmic surgery; testectomy; pancreatectomy; Perikardektomiya; The period of rehabilitation after surgery; The period of convalescence after surgery; Percutaneous transluminal coronary angioplasty; Pleural thoracentesis; Pneumonia postoperative and posttraumatic; Preparation for surgical procedures; Preparation for surgery; Preparation of the surgeon's hands before surgery; Preparation of the colon for surgical procedures; Postoperative aspiration pneumonia in neurosurgical and thoracic surgery; Postoperative nausea; Postoperative bleeding; postoperative granuloma; postoperative shock; The early postoperative period; myocardial revascularization; Radiectomy; gastric Resection; bowel resection; uterine Resection; liver Resection; enterectomy; Resection of part of the stomach; Reocclusion of the operated vessel; Bonding tissues during surgical procedures; Removal of sutures; Condition after eye surgery; Condition after surgery; Condition after surgery in the nasal cavity; Condition after gastrectomy; Status after resection of the small intestine; Condition after tonsillectomy; Condition after removal of the duodenum; Condition after phlebectomy; Vascular surgery; Splenectomy; Sterilization of surgical instruments; Sterilization of surgical instruments; sternotomy; Dental surgery; Dental intervention in periodontal tissues; strumectomy; Tonsillectomy; Thoracic surgery; Thoracic surgery; total gastrectomy; Transdermal intravascular coronary angioplasty; Transurethral resection; Turbinektomiya; Removal of a tooth; cataract surgery; Removal of cysts; tonsillectomy; Removal of fibroids; Removing the mobile primary teeth; Removing polyps; Removing broken tooth; Removal of the uterus body; Removal of sutures; Fistula likvoroprovodyaschih ways; Frontoetmoidogaymorotomiya; Surgical infection; Surgical treatment of chronic limb ulcers; Surgery; The surgery in the anal area; The surgery on the colon; Surgical practice; The surgical procedure; Surgical interventions; Surgery on the gastrointestinal tract; Surgical procedures on the urinary tract; Surgical procedures on the urinary system; Surgical intervention of the genitourinary system; Surgical procedures on the heart; Surgical manipulation; surgery; Surgery on the veins; Surgical intervention; Vascular surgery; Surgical treatment of thrombosis; Surgery; cholecystectomy; Partial gastric resection; hysterectomy; Percutaneous transluminal coronary angioplasty; Percutaneous transluminal angioplasty; Coronary artery bypass; tooth Extirpation; Extirpation of milk teeth; pulpectomy; pulsative cardiopulmonary bypass; tooth Extraction; teeth Extraction; cataract extraction; Electrocoagulation; endourological intervention; episiotomy; Etmoidotomiya; Complications after tooth extraction

Pharmacology

Mode of action - Anticoagulant, antithrombotic.

Quickly absorbed with SC the introduction. T1 / 2 - 3-4 hours Badly passes gistogematicheskie barriers. Do not penetrate the placenta (you can enter during pregnancy), in small amounts falls into the mother's milk. Blocking the X factor, it acts on the initial stage of coagulation, has a pronounced and prolonged antithrombogenic effect, with the possibility of bleeding being insignificant (has a weak anticoagulant effect and does not change the general blood coagulation tests in usual doses). Does not affect the aggregation and adhesion of platelets when using conventional doses.

Application of substance Reviparin sodium

Deep vein thrombosis, thromboembolism during and after surgery, thrombosis of veins during pregnancy, thrombosis in patients with long standing in a horizontal position.

Contraindications

Hypersensitivity, thrombocytopenia, tendency to bleeding (hemophilia, increased bleeding of the wounds, subdural hematoma), craniocerebral trauma, intracranial hemorrhage, surgical operations on the central nervous system, lumbar punctures, spinal or epidural anesthesia, bacterial endocarditis, threatening miscarriage, acute erosive ulcerative lesions Gastrointestinal tract, pregnancy (I trimester).

Restrictions

Arterial hypertension, retinopathy, hepatic and / or renal failure, pancreatitis, fresh cerebrovascular lesions, recent surgical interventions on the brain, brain trauma, children's age (clinical experience of treating children is absent).

Pregnancy and breast-feeding

Not recommended.

Side effects of the substance Reviparin sodium

Bleeding, thrombocytopenia (including in combination with consumption coagulopathy), necrosis of the skin at the injection site, petechia, purpura, melena, increased activity of serum transaminases, LDH, lipase, hyperkalemia, hypoaldosteronism, priapism, vasospasm, local tissue reactions (hyperemia , Depigmentation, small hematomas), allergic reactions (nausea, headache, hyperthermia, pain in the extremities, hives, itching, shortness of breath, bronchospasm, hypotension).

Interaction

Pharmaceutically incompatible with other drugs (forms salts and a sediment with organic bases). Dicumarol, dextran solutions, acetylsalicylic acid, dipyridamole, phenylbutazone, indomethacin, sulfinpyrazone increase the risk of bleeding. Ascorbic acid, antihistamines, cardiac glycosides, nicotine, tetracyclines, phenothiazine, nitrates (parenteral administration), penicillin reduce effectiveness.

Overdose

Characterized by the symptomatology of hypocoagulation.

Treatment: IV is slowly injected protamine (neutralizes anti-IIa activity in its entirety, and anti-Xa activity in part) at the rate of 1 mg protamine per 100 anti-Xa units of reviparin.

Routes of administration

SC

Precautions for the substance Reviparin sodium

Careful medical supervision is necessary in the appointment of elderly patients, especially women, in combination with drugs that raise the level of potassium in the blood serum. Avoid injections due to the risk of hematoma. In the period of treatment, platelet counting is mandatory (before the injection, after the first and fourth days of treatment and further - 2 times a week).

Special instructions

Low molecular weight heparins differ in the way of production, molecular weight and activity, so it is not recommended to replace one drug with another during treatment. Women who received the drug, epidural anesthesia during labor is absolutely contraindicated.