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Instruction for use: Retinoic ointment

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Active substance Isotretinoin

ATX code D10AD04 Isotretinoin

Pharmacological group

dermotropic means

Composition and form of release

Ointment for external use

isotretinoin (13-cis-retinoic acid) 0.05 g

0.1 g

auxiliary substances: dibunol; butyloxyanisole; wax emulsion; oil vaseline; glycerol; ethyl alcohol 95%; purified water - up to 100 g

in tubes of 10 g; in a pack of cardboard 1 tuba.

Description of dosage form

Homogeneous ointment from light yellow to yellow.

pharmachologic effect

Pharmacological action - anti-inflammatory, keratolytic, anti-seborrheic, dermatoprotective.

Retinoic acid - a biologically active form of vitamin A, is involved in the regulation of cell differentiation.

Clinical Pharmacology

It inhibits the hyperproliferation of the epithelium of the excretory ducts of the sebaceous glands, reduces the formation of sebum, facilitates its evacuation, reduces the inflammatory reaction around the glands. Strengthens the regeneration processes in the skin.


Acne vulgaris, seborrheic dermatitis, rosacea, perioral dermatitis.


It is not recommended to apply to large areas of the skin during pregnancy, breast-feeding and women planning pregnancy. Do not prescribe to patients receiving other drugs from the group of retinoids. With caution - with chronic liver disease, kidney disease, chronic pancreatitis, cardiac decompensation.

Side effects

Passing reddening of the skin, new rashes from the 2nd week of treatment, not requiring withdrawal of the drug. Sometimes - an individual intolerance.

Possible (with prolonged use) - cheilitis, conjunctivitis, dryness and peeling of the skin.


The effect of the ointment is weakened with the simultaneous administration of tetracycline antibiotics, as well as the local application of glucocorticosteroids.

Dosing and Administration

Outwardly. For acne and rosacea apply a thin layer on the affected skin 2 times a day. Duration of treatment - 4-12 weeks. Repeated course is possible after consultation with a doctor.

special instructions

Do not apply ointment on the skin around the eyes and with severe acute inflammation. Do not apply to mucous membranes.

storage conditions

At a temperature of 2-8 C (do not freeze).

Keep out of the reach of children.

Shelf life

2 years.

Do not use after the expiry date printed on the package.

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